1950
DOI: 10.1111/j.1365-2621.1950.tb16470.x
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EFFECT OF SINGLE ASD REPEATED DOSES OF GOSSYPOL OK THE RAT1

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Cited by 21 publications
(9 citation statements)
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“…Autopsies on deceased rats revealed either severe affections of lung, liver, kidney and gastrointestinal tract or the apparently normal status of the organs. Very similar organ damages were numerously reported from rats that had died during gossypol treatment (Eagle and Bialek -1950;El-Nockrashy et al -1963;Abou-Donia -1980). It is assumed that gossypol, besides other effects, might interfere with the availability of free iron (which then is bound to gossypol) and promote nitrogen loss via urinary excretion leading to edema and eventually to death (Bressani -1980).…”
Section: Discussionsupporting
confidence: 72%
“…Autopsies on deceased rats revealed either severe affections of lung, liver, kidney and gastrointestinal tract or the apparently normal status of the organs. Very similar organ damages were numerously reported from rats that had died during gossypol treatment (Eagle and Bialek -1950;El-Nockrashy et al -1963;Abou-Donia -1980). It is assumed that gossypol, besides other effects, might interfere with the availability of free iron (which then is bound to gossypol) and promote nitrogen loss via urinary excretion leading to edema and eventually to death (Bressani -1980).…”
Section: Discussionsupporting
confidence: 72%
“…All 3 samples of cottonseed pigment glands, however, despite their low gossypol content, were more toxic to the rat than any of the 5 samples of gossypol combination products containing 7.2 to 68.6% gossypol (A, B, C, D, F) or the sample of pure gossypol ( E ) . These data offer further evidence of lack of correlation between analyzed gossypol content and acute oral toxicity as was originally pointed out for the rat by Eagle et al (3,4,5 ) and subsequently confirmed by Ambrose and Robbins (1).…”
Section: 2supporting
confidence: 78%
“…In rats these include intestinal dilation and impaction, hemorrhagic congestion of the gastrointestinal tract, pulmonary and renal congestion, and degeneration of the seminiferous tubules. The LD50 value for gossypol in rats is between 2500 and 3300 mg/kg [3]. Of the domestic species, swine appear to be more sensitive than others in the development of toxic signs.…”
Section: Discussionmentioning
confidence: 99%