Effect of Single-Dose Sertraline on the Hypothalamus-Pituitary-Adrenal System, Autonomic Nervous System, and Platelet Function

Ahrens, Thorben; Frankhauser, Pascal; Lederbogen, Florian; Deuschle, Michael

doi:10.1097/jcp.0b013e31815abf0e

Cited by 25 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, previous studies reported conflicting results, and time after initiation of treatment and the clinical state seem to be important variables. Some studies reported increased HRV variability during SSRI treatment (50 -52) whereas others found no difference or a reduction (1,(53)(54)(55). Here, we included a large set of autonomic parameters to allow more detailed insights into autonomic function.…”

Section: Discussionmentioning

confidence: 97%

Autonomy of Autonomic Dysfunction in Major Depression

Koschke

Boettger²,

Schulz³

et al. 2009

Psychosomatic Medicine

181

108

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Autonomy of Autonomic Dysfunction in Major Depression

Koschke

Boettger²,

Schulz³

et al. 2009

Psychosomatic Medicine

181

108

View full text Add to dashboard Cite

show abstract

“…The effect of selective serotonin reuptake inhibitor anti- depressants (SSRIs) on HRV was much less clear. Some studies reported increased HRV during SSRI treatment (28,39,53), whereas others found no difference or a reduction (1,12,37). SNRIs were reported to reduce HRV in most of studies (41,54,56).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of desvenlafaxine on gastric slow waves, antral contractions, and gastric accommodation mediated via the sympathetic mechanism in dogs

Dai¹,

Lei²,

Chen

2011

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

Desvenlafaxine succinate (DVS; Pristiq) is a new antidepressant, serotonin-norepinephrine reuptake inhibitor. Antidepressants have been widely used for the treatment of functional gastrointestinal disorders. Possible roles of DVS on gastrointestinal motility have not been studied. The aim of this study was to investigate the effects of DVS on gastric slow waves (GSW), antral contractions, and gastric accommodation in dogs. Fifteen healthy dogs implanted with gastric serosal electrodes and a gastric cannula were studied in four separate sessions: control, DVS (50 mg), propranolol (1 mg·kg Ϫ1 ·h Ϫ1 ), and propranolol ϩ DVS. GSW were measured via the gastric serosal electrodes. Antral contractions were assessed via an intraluminal manometric catheter inserted via the gastric cannula. The sympathovagal activity was assessed from the spectral analysis of the heart rate variability signal. Gastric tone was measured by barostat via an intragastric balloon inserted into the fundus via the gastric cannula. In the postprandial period, in comparison with the control, DVS reduced the percentage of normal GSW (P ϭ 0.001) and increased the percentage of tachygastria (P ϭ 0.005) and bradygastria (P ϭ 0.002). Simultaneously, DVS increased the sympathetic activity (P ϭ 0.006) and the sympathovagal ratio (low frequency/high frequency; P ϭ 0.044). These effects were blocked by propranolol. DVS attenuated postprandial antral contractions and gastric accommodation. The postprandial antral contractile index (area under the curve) was decreased by 26% with DVS (P ϭ 0.013), and gastric accommodation was decreased by about 50% with DVS (P Ͻ 0.001). The inhibitory effect of DVS on gastric accommodation was blocked by propranolol. DVS inhibits gastric contractions, slow waves, and accommodation in the fed state. These inhibitory effects are associated with an increased sympathetic modulation in the gastrointestinal system. Cautions should be made when DVS is used for treating patients with depression and gastric motility disorders. desvenlafaxine succinate; antidepressants; gastrointestinal motility ANTIDEPRESSANTS ARE WIDELY used for the treatment of functional gastrointestinal disorders, such as functional dyspepsia and irritable bowel syndrome (17,20,55). The rationale for the use of antidepressants in functional gastrointestinal disorders is based on the following potential effects. First, antidepressants may improve psychiatric and psychological symptoms, particularly anxiety and depression (11,18,47). Second, antidepressants have central analgesic actions and alter central processing of visceral pain stimuli (10, 27). Third, antidepressants may have local pharmacological actions on the gut and modulate gut sensorimotor functions (3,8,9).Desvenlafaxine succinate (DVS; Pristiq) is a new antidepressant, the third serotonin-norepinephrine reuptake inhibitor (SNRI) approved by the U.S. Food and Drug Administration for the treatment of major depressive disorders in 2008 (26, 35). It is a novel salt form of the isolated major active metab...

show abstract

“…Ahrens and colleagues [62] found no effect of a single dose sertraline treatment on HRV in healthy young adults. In Heart Fail Rev (2009) 14:35-50 37 contrast, Glassman and colleagues [63] observed decreased HRV in depressed patients treated with sertraline vs. placebo following acute coronary syndrome.…”

Section: Autonomic Nervous System Function and Treatment Of Depressionmentioning

confidence: 97%

Psychobiology of depression/distress in congestive heart failure

2008

View full text Add to dashboard Cite

Heart failure affects millions of Americans and new diagnosis rates are expected to almost triple over the next 30 years as our population ages. Affective disorders including clinical depression and anxiety are common in patients with congestive heart failure. Furthermore, the presence of these disorders significantly impacts quality of life, medical outcomes, and healthcare service utilization. In recent years, the literature has attempted to describe potential pathophysiologic mechanisms relating affective disorders and psychosocial stress to heart failure. Several potential mechanisms have been proposed including autonomic nervous system dysfunction, inflammation, cardiac arrhythmias, and altered platelet function. These mechanisms are reviewed in this article. Additional novel mechanisms such as mental stress-induced myocardial ischemia are also discussed.

show abstract

Effect of Single-Dose Sertraline on the Hypothalamus-Pituitary-Adrenal System, Autonomic Nervous System, and Platelet Function

Cited by 25 publications

References 39 publications

Autonomy of Autonomic Dysfunction in Major Depression

Autonomy of Autonomic Dysfunction in Major Depression

Inhibitory effects of desvenlafaxine on gastric slow waves, antral contractions, and gastric accommodation mediated via the sympathetic mechanism in dogs

Psychobiology of depression/distress in congestive heart failure

Contact Info

Product

Resources

About