Effect of single to triple dose DEC on microfilaremics up to 5 years

Chandra, Goutam; Paramanik, Manas

doi:10.1007/s00436-008-1126-x

Cited by 11 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the fact that single-dose DEC treatment was found effective for reduction of microfilaremia and parasite load, but it is not always sufficient to eliminate all the microfilariae, especially when mean microfilariae density was high (>40; Chandra and Paramanik 2008). Research findings suggest that logistical and operational aspects (Ramaiah et al 2000a, b) and parasite dynamics in humans in relation to the number of annual treatments (Das et al 2001) have significant implications on the program to eliminate LF.…”

Section: Research Findings and Challenges To The Current Elimination mentioning

confidence: 89%

Diurnally subperiodic filariasis in India—prospects of elimination: precept to action?

Shriram

Krishnamoorthy

Saha³

et al. 2011

Parasitol Res

View full text Add to dashboard Cite

The elimination of lymphatic filariasis in the Andaman and Nicobar Islands provides unique opportunities and challenges at the same time. Since these islands are remote, are sparsely populated, and have poor transport networks, mass drug administration programs are likely to be difficult to implement. Diurnally subperiodic Wuchereria bancrofti vectored by Downsiomyia nivea was considered for the scope of vector control options. Considering the bioecology of this mosquito, vector control including personal protection measures may not be feasible. However, since these islands are covered by separate administrative machinery which also plays an important role in regulating the food supply, the use of diethylcarbamazine (DEC)-fortified salt as a tool for the interruption of transmission is appealing. DEC-fortified salt has been successfully pilot tested in India and elsewhere, operationally used by China for eliminating lymphatic filariasis. Administration of DEC-fortified salt though simple, rapid, safe, and cost-effective, challenges are to be tackled for translating this precept into action by evolving operationally feasible strategy. Although the use of DEC-fortified salt is conceptually simple, it requires commitment of all sections of the society, an elaborate distribution mechanism that ensures the use of DEC-fortified salt only in the endemic communities, and a vigorous monitoring mechanism. Here, we examine the inbuilt administrative mechanisms to serve the tribal people, health infrastructure, and public distribution system and discuss the prospects of putting in place an operationally feasible strategy for its elimination.

show abstract

Section: Research Findings and Challenges To The Current Elimination mentioning

confidence: 89%

Diurnally subperiodic filariasis in India—prospects of elimination: precept to action?

Shriram

Krishnamoorthy

Saha³

et al. 2011

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…The study area is endemic for LF. 16 Most of the married women of the area are deprived of higher education often with very little awareness about health and hygiene. Mainly they are housewives but a large proportion (mostly the backward poorer section) also work as low income daily labourers in unorganised sectors (like farming, construction, housekeeping etc.)…”

Section: Discussionmentioning

confidence: 99%

Impact of Lymphatic Filariasis on Married Women from Rural Areas of Bankura District, West Bengal, India

Paramanik

Sarkar

Chandra

2021

JCD

Self Cite

View full text Add to dashboard Cite

In third world countries like India, women play a vital role in building and maintaining the family and the society. Lymphatic Filariasis (LF) among married women may inflict a deep impact on the society. Present study was focused to study the impact of LF on married women of some rural areas of Bankura district in West Bengal, India. Night blood-samples of 1202 married women were examined to detect the presence of microfilariae. They were examined clinically and also asked for any hidden filarial manifestation. Affected subjects were also interrogated to understand the impact of LF on their lives. Microfilaria rate, mean microfilaria density and disease rate among the married women of the area were assessed as 6.16%, 10.89% and 11.98% respectively. 95.83% of the diseased subjects were of opinion that the disease had imposed some or many adverse effects on their lives. The diseased women suffer from disability, loss of efficiency and social stigma. They are often neglected and abstain themselves from intimating their problems to the family members and seeking help for various reasons. Awareness level is poor and presumably the situation is same in the rural areas of other under developed and developing countries.

show abstract

“…quinquefasciatus is the principal transmitter in most regions [24][25][26] with a role played by other mosquito species as well [27,28] . To eliminate the disease, along with the application of chemotherapeutic strategies [29] , a vector control strategy is vital [8,23] . The present study was intended to evaluate the larvicidal role of leaf extract of V. spinosa on filarial vector Cx.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Int. J. Mosq. Res.

View full text Add to dashboard Cite

Culex quinquefasciatus is the transmitter of some dreadful vector-borne diseases. Such diseases can be controlled by managing the vector population. In this study, the mosquito larvicidal activity of the leaf extracts of a deciduous shrub Vangueria spinosa was evaluated for the first time. Larval mortalities were assessed using crude and different solvent extracts of young leaves of V. spinosa with different concentrations following standard methods. Thin-layer chromatography was done to characterize the major bioactive components liable for larval mortality. Cent percent mortality of the third instar larvae of Cx. quinquefasciatus was recorded at 2.5% concentration of crude extract within 48 hrs. Chloroform: Methanol extract was found to be the deadliest and 100% mortality of third instar larvae was reached in 48 hrs at 50 ppm concentration. The active ingredient which seems to be mainly responsible for larval mortality was steroidal in nature. LC50 of the fraction was calculated as 13.34 ppm for third instar larvae in 24 hrs. No significant effect of these extracts was noted on non-target organisms. So, the leaf of V. spinosa can be used as a potential source for the preparation of mosquito larvicide.

show abstract

Effect of single to triple dose DEC on microfilaremics up to 5 years

Cited by 11 publications

References 7 publications

Diurnally subperiodic filariasis in India—prospects of elimination: precept to action?

Diurnally subperiodic filariasis in India—prospects of elimination: precept to action?

Impact of Lymphatic Filariasis on Married Women from Rural Areas of Bankura District, West Bengal, India

Untitled

Contact Info

Product

Resources

About