Effect of Sirolimus in the Prevention of Adhesions Around Intraabdominal Prosthetic Graft

Kanko, Mühip; Özbudak, Ersan; Ozerdem, Ali; Aksoy, Aziz; Kilic, Metehan; Berki, K. Turan

doi:10.1007/s00268-005-0750-1

Cited by 14 publications

(5 citation statements)

References 30 publications

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“…Formerly, tacrolimus has reduced peritoneal adhesions after a bowel transplantation model in rats (24). Another immunosuppressive drug sirolimus, have been found to reduce intraabdominal adhesions in an intraabdominal prosthetic vascular graft model and ventral prosthetic mesh model (26, 27). …”

Section: Discussionmentioning

confidence: 99%

Prevention of Intraabdominal Adhesions by Local and Systemic Administration of Immunosuppressive Drugs

Peker¹,

Inal²,

Sayar³

et al. 2013

Iran Red Cres Med J

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Background:Intraperitoneal adhesion formation is a serious postsurgical issue. Adhesions develop after damage to the peritoneum by surgery, irradiation, infection or trauma.Objectives:Using a rat model, we compared the effectiveness of systemic and intraperitoneally administered common immunosuppressive drugs for prevention of postoperative intraperitoneal adhesions.Materials and Methods:Peritoneal adhesions were induced in 98 female Wistar-Albino rats by cecal abrasion and peritoneal excision. Rats were randomly separated into seven groups, each containing fourteen rats, and the standard experimental model was applied to all of rats. 14 days later, rats were euthanized, intraperitoneal adhesions were scored and tissues were examined histologically using hematoxylin/eosin and Masson’s trichrome staining.Results:Throughout the investigation, no animal died during or after surgery. In all of experimental groups, decrease in fibrosis was statistically significant. Decrease in fibrosis was most prominently in intraperitoneal tacrolimus group (P = 0.000), and decrease was least in intraperitoneal cyclosporine group (P = 0.022). Vascular proliferation was significantly decreased in all experimental groups (P < 0.05) except for systemic tacrolimus group (P = 0.139). Most prominent reduction in vascular proliferation was in intraperitoneal tacrolimus group (P = 0.000).Conclusions:Administration of immunosuppressive drugs is effective for prevention of intraperitoneal adhesions.

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Section: Discussionmentioning

confidence: 99%

Prevention of Intraabdominal Adhesions by Local and Systemic Administration of Immunosuppressive Drugs

Peker¹,

Inal²,

Sayar³

et al. 2013

Iran Red Cres Med J

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“…Th1 CD4 + ąß cells are crucial for developing intraperitoneal adhesions, and shortly after tissue injury and throughout adhesiogenesis, these activated T-cells become predominant in the abdominopelvic cavity 42 , 43 . Therefore, several immunosuppressive agents have been proven to reduce postoperative intraperitoneal adhesions in experimental models, such as Tacrolimus 44 , Sirolimus 13 , 19 , 45 , mycophenolate mofetil, and cyclosporine 46 . However, it has been formerly demonstrated that vascular toxicity mediated by Calcineurin inhibitors, such as cyclosporine and tacrolimus, might induce endothelial damage leading to impaired fibrinolytic capacity 47 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effect of Everolimus, Prednisolone, and a combination of both on experimentally induced peritoneal adhesions in rats

Kazemi,

Jamshidi,

Naseri

et al. 2024

Sci Rep

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Postoperative intra-abdominal adhesions represent a significant post-surgical problem. Its complications can cause a considerable clinical and cost burden. Herein, our study aimed to investigate the effect of Everolimus on peritoneal adhesion formation after inducing adhesions in rats. In this experimental study, adhesion bands were induced by intraperitoneal injection of 3 ml of 10% sterile talc solution in 64 male albino rats. The first group served as the control group. The second one received oral Prednisolone (1 mg/kg/day), the third received Everolimus (0.1 mg/kg/day), and group four received both drugs with similar dosages for four consecutive weeks. The formation of adhesion bands was qualitatively graded according to the Nair classification. The rats in the control group had extensive adhesions between the abdominal wall and the organs. Regarding substantial adhesion formation, 50% (8/16) of animals in the control group had substantial adhesions, while this rate in the groups receiving Prednisolone, Everolimus, and combination treatment was 31%, 31%, and 31%, respectively. Also, 68.75% (5/11) of the Prednisolone recipients had insubstantial adhesions, the same as Everolimus recipients, while in the combination group, 66.66% (10/15) rats had insubstantial adhesions. Everolimus demonstrated satisfactory results in reducing the rates of induced peritoneal adhesion in an experimental model, similar to Prednisolone and superior to a combination regime.

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“…IL-6 also has been shown to significantly increase the intraperitoneal adhesions (14,15). Former studies with immunosuppressive agents showed adhesion prevention with tacrolimus in a bowel transplantation model (4), with sirolimus in an intraabdominal prosthetic graft model (16) and parietal synthetic mesh model (17). Sirolimus is a new generation immunosuppressive drug with low and well-defined adverse effect profile.…”

Section: Discussionmentioning

confidence: 99%

Effect of intraperitoneal and systemic sirolimus administration on postoperative peritoneal adhesions in rats

Inal¹,

Saydam

2021

Journal of Basic and Clinical Health Sciences

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Purpose: Low incidence of surgery-induced peritoneal adhesions in posttransplant patients is a wellknown subject. The aim of this study was to investigate the role sirolimus to prevent intra-abdominal adhesions and compare the systemic and intraperitoneal efficacy of the intervention. Methods: A total of 21 male rats randomly constituted three groups as intraperitoneal 0.015mg/kg sirolimus administered group, 0.1 mg/kg oral sirolimus administered group, and control group. A surgical peritoneal adhesion model was performed. All rats were euthanized on postoperative 7. day for macroscopic adhesion evaluation and histopathologic examination. Results: Intraperitoneal sirolimus administration significantly reduced adhesion formation. On the other hand, one-dose systemic administration did not show significant difference compared with control group. Conclusions: Intraperitoneal sirolimus administration at therapeutic doses significantly reduces postoperative intraabdominal adhesions in rat model.

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Effect of Sirolimus in the Prevention of Adhesions Around Intraabdominal Prosthetic Graft

Abstract: Therefore, sirolimus applied around the prosthesis in vascular operations was determined to be effective at preventing possible adhesions.

Cited by 14 publications

References 30 publications

Prevention of Intraabdominal Adhesions by Local and Systemic Administration of Immunosuppressive Drugs

Prevention of Intraabdominal Adhesions by Local and Systemic Administration of Immunosuppressive Drugs

Comparison of the effect of Everolimus, Prednisolone, and a combination of both on experimentally induced peritoneal adhesions in rats

Effect of intraperitoneal and systemic sirolimus administration on postoperative peritoneal adhesions in rats

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