Effect of Sitagliptin and Glimepiride on Pancreatic Beta-Cells during the Treatment of Type-2 Diabetic Mellitus by Statistical Analysis

Joshi, B.N.; Yadav, Praveen Kumar; Bhavani, A. Geetha

doi:10.9734/jpri/2020/v32i2930887

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Microspheres in the finished product are in a dry powder form. Prior to administration, a microsphere product is reconstituted in a liquid diluent which can be supplied in a separate container or in the liquid compartment of a dualchamber prefilled syringe [11,12].…”

Section: Introductionmentioning

confidence: 99%

Preformulation Study of Glimepiride: An Insight for Formulation and Development of Parenteral Formulation

Patel

Suthar

Patel

et al. 2022

JPRI

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Aim: The objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic profile, compatibility with other formulation excipients and physico-chemical parameters of new drug substance. This could provide important information for formulation design or support the need for molecular modification. So, in the present study preformulation studies were performed on Glimepiride (GMP) to assess its suitability for parenteral formulation. Glimepiride is the first IIIrd generation sulphonyl urea used to treat type –II diabetes mellitus. Methods: The authenticity of GMP was established by DSC and FTIR spectra. A UV spectrophotometric method and HPLC method were employed for determination of GMP in bulk active pharmaceutical ingredient (API). Results: The UV method was linear in the range of 3-10 μg/ml. The low % CV values of intra-day and inter-day variations revealed that the proposed method is robust. The retention time of GMP in HPLC method was found to be 1.9 min. The method was proven robust by obtaining very high regression coefficient value (0.999). Conclusions: The results of the physicochemical study of drug revealed suitability of GMP for parenteral route. Moreover, the drug was found stable in both solid as well as liquid state at different conditions.

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Section: Introductionmentioning

confidence: 99%

Preformulation Study of Glimepiride: An Insight for Formulation and Development of Parenteral Formulation

Patel

Suthar

Patel

et al. 2022

JPRI

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“…Obesity in both industrialized and emerging countries, in children and adults, is the most typical type of malnutrition to be seen globally [4]. It is the sixth most crucial worldwide mortality risk factor [3].…”

Section: Introductionmentioning

confidence: 99%

A Brief Study on Diabetes Mellitus: Pathophysiology and Diagnosis

Verma

Chakole

Laishram

2021

JPRI

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Background: This article reviews published articles and existing diagnostic and therapeutic techniques relevant to adolescents with obesity and diabetes mellitus. Obesity, in addition to DIABETES MELLITUS, is a crucial risk factor for the occurrence of future chronic and noncommunicable diseases. Obese and overweight teenagers are more prone to acquire Adult Onset Diabetes, formerly rare among the younger population. However, a global trend of Adult Onset Diabetes was noted in the late 1990s and early 2000s. In the United States and the United Kingdom, and other developing and developed countries, this is particularly true. Adult Onset Diabetes is nearly as common as Insulin Dependent Diabetes in some locations. There has been a significant surge in the prevalence and severity of obesity in several population groups in teenagers. Objective and Methodology: To read and review the existing literature on the prevalence of Diabetes Mellitus and obesity in adolescence. About 15 articles and literature were studied using the PubMed and Google Scholar search engine to produce a detailed review article on the topic of interest so chosen. Results and Conclusion: After reviewing the articles, we can agree that TYPE-2 DIABETES MELLITUS is linked easily to young adults who are obese, that is, having a Body Mass Index of more than 30 or more than 30. TYPE-2 DIABETES MELLITUS causes destruction of receptors for insulin which results in an increased level of glucose, causing various diseases. Obesity in young adults is a critical factor in the occurrence of Adult Onset Diabetes which makes them at risk of developing severe diseases in the 3rd or 4th decade of life.

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Effect of Sitagliptin and Glimepiride on Pancreatic Beta-Cells during the Treatment of Type-2 Diabetic Mellitus by Statistical Analysis

Cited by 2 publications

References 13 publications

Preformulation Study of Glimepiride: An Insight for Formulation and Development of Parenteral Formulation

Preformulation Study of Glimepiride: An Insight for Formulation and Development of Parenteral Formulation

A Brief Study on Diabetes Mellitus: Pathophysiology and Diagnosis

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