Effect of skin temperature on the ion reabsorption capacity of sweat glands during exercise in humans

Shamsuddin, A. K. M.; Kuwahara, Tomoko; Oue, Anna; Nomura, C.; Koga, Shunsaku; Inoue, Yoshimitsu; Kondo, Narihiko

doi:10.1007/s00421-005-1354-z

Cited by 21 publications

(33 citation statements)

References 28 publications

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“…The unchanged slope, coupled with increased electrolyte reabsorption, found in the present study would be consistent with the data of Shamsuddin et al (27). They altered sodium reabsorption of the eccrine sweat gland by changing skin temperature.…”

Section: Discussionsupporting

confidence: 94%

Sodium ion concentration vs. sweat rate relationship in humans

Buono

Ball²,

Kolkhorst³

2007

Journal of Applied Physiology

154

120

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The purpose of this study was to determine the effect of active heat acclimation on the sweat osmolality and sweat sodium ion concentration vs. sweat rate relationship in humans. Eight healthy male volunteers completed 10 days of exercise in the heat. The mean exercising heart rate and core temperature were significantly decreased (P < 0.05) by 18 beats/min and 0.6 degrees C, respectively, following heat acclimation. Furthermore, sweat osmolality and the sweat sodium ion concentration vs. sweat rate relationships were shifted to the right. Specifically, the slopes of the relationships were not affected by heat acclimation. Rather, heat acclimation significantly reduced the y-intercepts of the sweat osmolality and sweat sodium relationships with sweat rate by 28 mosmol/kgH(2)O and 15 mmol/l, respectively. Thus there was a significantly lower sweat sodium ion concentration for a given sweat rate following heat acclimation. These results suggest that heat acclimation increases the sodium ion reabsorption capacity of the human eccrine sweat gland.

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Section: Discussionsupporting

confidence: 94%

Sodium ion concentration vs. sweat rate relationship in humans

Buono

Ball²,

Kolkhorst³

2007

Journal of Applied Physiology

154

120

View full text Add to dashboard Cite

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“…1 ) suggests that during physical activity there is a higher autonomic response to enable the dissipation of heat, and that this may prevent hyperthermia and sustain performance [35,38] . The thermal stimuli to the sweating response are both internal and skin temperature, and both of these can modulate variations in the sweat rate [8,10,26,37] . However, the sweat rate can be infl uenced by exercise intensity [20,21,24,44] , environmental conditions [1,4,7,13,43,45] , hydration level [12,14,24,36] and heat acclimation [23,27,29,31] .…”

Section: Discussion ▼mentioning

confidence: 99%

Head Hair Reduces Sweat Rate During Exercise Under the Sun

Coelho

Júnior²,

Martini³

et al. 2010

Int J Sports Med

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The purpose of this study was to evaluate the effects of human head hair on thermoregulation during exercise carried out under solar radiation. 10 healthy male subjects (mean±SD: 25.1±2.5 yr; height: 176.2±4.0 cm; weight: 73.7±6.7 kg; VO(2max) 56.2±5.3 mLO(2)·kg (-1)·min (-1)) took part in 2 1 h-long trials of continuous exercise on a treadmill at 50% VO2(max) under solar radiation that were separated by at least 2 days. Whereas for the first trial they retained their natural head hair (HAIR), in the second trial their hair was totally shaved (NOHAIR). Several properties were measured, including environmental heat stress (Wet Bulb Globe Temperature index - WBGT, °C), heart rate, rectal temperature, skin temperature, head temperature, and global sweat rate. The main findings were that whereas there was a lower sweat rate in the HAIR condition (HAIR: 7.08±0.79 vs. NOHAIR: 7.67±0.79 g·m (-2)·min (-1); p=0.03), there were no significant differences in any of the other variables between the HAIR and NOHAIR trials. In conclusion, the presence of head hair resulted in a lower sweat rate.

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“…Increases in local temperature of this magnitude sensitize the sweating responses without inducing local axon reflexes and prevent cold‐induced decreases in sweating and ion trafficking associated with skin temperature observed in air‐conditioned environments (Benzinger, ; Shibasaki & Crandall, ; Shamsuddin et al . ). In both protocols, one probe was perfused with six 5 min doses of ACh (1 × 10 −5 to 1 × 10 0 m , 10‐fold increments) alone.…”

Section: Methodsmentioning

confidence: 97%

“…Subsequently, local skin temperature within the area of measurement was raised and stabilized to ß38°C using a 250 W infrared-heat lamp during sweating protocols. Increases in local temperature of this magnitude sensitize the sweating responses without inducing local axon reflexes and prevent cold-induced decreases in sweating and ion trafficking associated with skin temperature observed in air-conditioned environments (Benzinger, 1961;Shibasaki & Crandall, 2001;Shamsuddin et al 2005).…”

Section: Instrumentation and Protocolsmentioning

confidence: 99%

Extracellular calcium chelation and attenuation of calcium entry decrease in vivo cholinergic‐induced eccrine sweating sensitivity in humans

Metzler-Wilson

Sammons

Ossim

et al. 2013

Experimental Physiology

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New Findings r What is the central question of this study?Calcium is an important second messenger in eccrine sweating; however, whether modulation of extracellular Ca 2+ and Ca 2+ entry has the capacity to modulate sweat rate in non-glabrous human skin has not been explored. r What is the main finding and its importance?Acetylcholine to sweat rate dose-response relationships identify that local in vivo Ca 2+ chelation and L-type Ca 2+ channel antagonism have the capacity to attenuate the cholinergic sensitivity of eccrine sweat glands. Importantly, these data translate previous glabrous in vitro animal studies into non-glabrous in vivo human skin.Calcium is an important second messenger in eccrine sweating, with both internal and external sources being identified in vitro. It is unclear whether in vivo modulation of extracellular Ca 2+ levels or influx has the capacity to modulate sweat rate in non-glabrous human skin. To test the hypothesis that lowering interstitial Ca 2+ levels would decrease the sensitivity of the ACh to sweat rate (via capacitance hygrometry) dose-response relationship, nine healthy subjects received six ACh doses (1 × 10 −5 to 1 × 10 0 m in 10-fold increments) with and without a Ca 2+ chelator (12.5 mg ml −1 EDTA) via forearm intradermal microdialysis (protocol 1). To test the hypothesis that attenuating Ca 2+ influx via L-type Ca 2+ channels would also decrease the sensitivity of the ACh to sweat rate dose-response relationship, 10 healthy subjects received similar ACh doses with and without a phenylalkylamine Ca 2+ channel blocker (1 mm verapamil; protocol 2). Non-linear regression curve fitting identified a right-shifted ED 50 in EDTA-treated sites compared with ACh alone (−1.0 ± 0.1 and −1.5 ± 0.1 logm, respectively; P < 0.05), but unchanged maximal sweat rate (0.60 ± 0.07 and 0.58 ± 0.11 mg cm −2 min −1 , respectively; P > 0.05) in protocol 1. Protocol 2 also resulted in a right-shifted ED 50 (verapamil, −0.9 ± 0.1 logm; ACh alone, −1.6 ± 0.2 logm; P < 0.05), with unchanged maximal sweat rate (verapamil, 0.45 ± 0.08 mg cm −2 min −1 ; ACh alone, 0.35 ± 0.06 mg cm −2 min −1 ; P > 0.05). Thus, local in vivo Ca 2+ chelation and L-type

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Effect of skin temperature on the ion reabsorption capacity of sweat glands during exercise in humans

Cited by 21 publications

References 28 publications

Sodium ion concentration vs. sweat rate relationship in humans

Sodium ion concentration vs. sweat rate relationship in humans

Head Hair Reduces Sweat Rate During Exercise Under the Sun

Extracellular calcium chelation and attenuation of calcium entry decrease in vivo cholinergic‐induced eccrine sweating sensitivity in humans

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