Effect of Sleeve Gastrectomy on Ghrelin, GLP-1, PYY, and GIP Gut Hormones

McCarty, Thomas R.; Jirapinyo, Pichamol; Thompson, Christopher C.

doi:10.1097/sla.0000000000003614

Cited by 82 publications

(45 citation statements)

References 53 publications

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“…Changes in ghrelin levels after bariatric surgery are presented in Table 1 [33,34,[82][83][84][85][86][87][88][89][90][91][92][93][94]. It is of note that during the first months after RYGB, fasting and postprandial ghrelin levels are decreased, but over the first postoperative year, ghrelin levels after RYGB gradually increase [34,[86][87][88][89][90].…”

Section: Ghrelinmentioning

confidence: 99%

“…The changes in postprandial levels of GIP after RYGB and SG are inconsistent [33,48,83,[97][98][99][100][101] (Table 1). On the other hand, GIP levels after AGB appear unchanged [33,56,[102][103][104] (Table 1).…”

Section: Gipmentioning

confidence: 99%

“…Postprandial levels of GLP-1 are significantly elevated after RYGB and SG [32][33][34]45,83,85,90], but they remain stable after AGB [56,89,91,94] (Table 1). The increase in postprandial GLP-1 levels after RYGB is more profound compared to SG in some studies [34,45], but not in all [90,108].…”

Section: Glp-1mentioning

confidence: 99%

“…Alterations in PYY levels after bariatric surgery [21,32,34,45,83,85,89,91,94,108,114] are described in Table 1. Postprandial PYY levels are elevated after RYGB and SG, with more potent changes after RYGB [34,91,108,114].…”

Section: Pyymentioning

confidence: 99%

“…Postprandial ↑↑ [23,34,48,89,90,91,94,97−99,101,114] Fasting ↔ [23,32−34,85,100,101,108,114] Postprandial ↑ [23,32−34,83,85,100,101] Fasting ↔ [33,56,89,91,94,103,104] Postprandial ↔ [56,89,91,94,103] Postprandial ↑↑[21,23,33,34,85,[89][90][91]94,108,114] Fasting ↔[21,23,[32][33][34]108,114] Postprandial ↑[21,[32][33][34]83,90,108,114] Fasting ↔[33,89,91,94] Postprandial ↔[89,91,94] …”

mentioning

confidence: 99%

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Do Gut Hormones Contribute to Weight Loss and Glycaemic Outcomes after Bariatric Surgery?

Papamargaritis

Roux

2021

Nutrients

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Bariatric surgery is an effective intervention for management of obesity through treating dysregulated appetite and achieving long-term weight loss maintenance. Moreover, significant changes in glucose homeostasis are observed after bariatric surgery including, in some cases, type 2 diabetes remission from the early postoperative period and postprandial hypoglycaemia. Levels of a number of gut hormones are dramatically increased from the early period after Roux-en-Y gastric bypass and sleeve gastrectomy—the two most commonly performed bariatric procedures—and they have been suggested as important mediators of the observed changes in eating behaviour and glucose homeostasis postoperatively. In this review, we summarise the current evidence from human studies on the alterations of gut hormones after bariatric surgery and their impact on clinical outcomes postoperatively. Studies which assess the role of gut hormones after bariatric surgery on food intake, hunger, satiety and glucose homeostasis through octreotide use (a non-specific inhibitor of gut hormone secretion) as well as with exendin 9–39 (a specific glucagon-like peptide-1 receptor antagonist) are reviewed. The potential use of gut hormones as biomarkers of successful outcomes of bariatric surgery is also evaluated.

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