Effect of Small Doses of Estrogen on Serum Lipids in Female Patients with Myocardial Infarction

Effect of Piperazine Oestrone Sulphate on Serum Lipids and Lipoproteins in Menopausal Women

“…In normal menopausal women, early studies showed a reduction of serum total cholesterol, and an elevation of total phospholipid on oestrogen therapy (Eilert 1949(Eilert , 1953 and these results were confirmed in women with coronary heart disease (Robinson et al 1957;Marmorston et al 1958). More recent studies have shown a considerable rise in serum triglycéride, and this has been described both with synthetic oestrogens such as mestranol (Aitken et al 1971) and ethinyloestradiol (Bollón et al 1975) and with natural oestrogens such as Premarin® (Robinson 8c Le Beau 1965).…”

Effect of Estrogens on Interlipid Relations in Men with Myocardial Infarction.

“…One such agent is estrogen, whose ability to lower serum cholesterol and/or raise phospholipids has been amply demonstrated (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). More direct evidence also exists that estrogens may actually be antiatherogenicas the rarity of myocardial infarction in cyclic women, experimental demonstration of antiatherogenesis in animals (20) and autopsy findings in men given estrogen in treatment of cancer (2 1).…”

“…Although many lipid determinations were made, we have reported ( 18,19) that lipid changes tended in this clinical trial to become maximal in about 3 months. We have therefore selected for our present purpose the last determination made before start of treatment (I) and the first determination made following 6 months of continuous treatment (11), using all available data from the clinical trial in which these conditions were met.…”

The Fate of the Nontreated Postmenopausal Woman: A Plea for the Maintenance of Adequate Estrogen From Puberty to the Grave

“…Women gradually lose their favorable protected status after the menopause; thus the incidence of coronary heart disease associated with hypercholesteremia becomes comparable with that for men of a similar age. Estrogen can change abnormal concentrations of cholesterol (even in men) to a more favorable level, and decrease the amount of coronary insufficiency and atherosclerosis (15, 19, 20). Recent controlled studies show that the lives of men and women with previous coronary atherosclerosis can be significantly lengthened by estrogen administration (15, 20).…”

“…Estrogen can change abnormal concentrations of cholesterol (even in men) to a more favorable level, and decrease the amount of coronary insufficiency and atherosclerosis (15, 19, 20). Recent controlled studies show that the lives of men and women with previous coronary atherosclerosis can be significantly lengthened by estrogen administration (15, 20). There seem to be compelling reasons why the beneficial protective effect of estrogen should be continued postmenopausally.…”