Effect of smoking and alcohol consumption on pulmonary tuberculosis among Batak ethnic population in Medan, Indonesia

Sinaga, Bintang Yinke Magdalena; Siregar, Yahwardiah; Amin, Mochamad; Sarumpaet, Sorimuda

doi:10.1088/1755-1315/125/1/012139

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Lifestyle factors such as smoking and alcohol consumption habits and food or diet type also influence the susceptibility to TB. Sinaga et al found that smoking and alcohol consumption habits in one specific ethnic were the risk factor for PTB disease in Indonesia [30].…”

Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

Sinaga

Amir

2021

Open Access Maced J Med Sci

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BACKGROUND: Tumor Necrosis Factor-alpha (TNF-α) is a pro-inflammatory cytokine that plays a role in immune response against tuberculosis (TB) infection. Polymorphism in TNF-α gene may be associated with susceptibility to pulmonary TB (PTB). AIM: The purpose of this study was to investigate whether TNF-α-308G/A gene polymorphism is associated with susceptibility to PTB in Medan city, Indonesia. METHODS: This is a case–control study with 100 PTB patients and 100 healthy control. TNF-α polymorphism genotyping was performed by polymerase chain reaction fragment length polymorphism method. RESULTS: There were 200 participants enrolled in this study. Most of the participants were male and were in the age range of 20–39 years. Genotyping examination revealed that in the TB group, AG and GG genotype was found in 80 people (80%) and 20 people (20%), respectively. There were no TB patients with AA genotypes. Whereas, in the control group, subjects with AA, AG, and GG genotypes were 2 (2%), 47 (47%), and 51 (51%), respectively. Statistical analysis showed that there was a significant relationship between TNF-α-308 G/A polymorphism and PTB, in which individuals with AG genotypes were 4.3 times more likely to suffer PTB compared to GG genotype (p < 0.001, 95% confidence interval (CI) 2.31–8.15). Further analysis showed that A allele increased the risk of TB incidence by 1.94-fold compared to the G allele (p = 0.002, 95% CI 1.27–2.98). CONCLUSIONS: There was a significant relationship between TNFα-308 G/A gene polymorphism and the susceptibility to PTB and A allele increases the risk of pulmonary TB compared to G allele.

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Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

Sinaga

Amir

2021

Open Access Maced J Med Sci

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“…Additionally, alcohol consumption has been correlated to an increased TB disease burden due to disruption in the activity of alveolar macrophages and neutrophils, epithelial barrier dysfunction, and surfactant secretion (Molina et al, 2010;Rehm et al, 2010;Simet & Sisson, 2015). Sinaga et al (2018) discovered that the habitual consumption of alcoholic beverage tuak by people of Batak ethnicity raises their risk of developing TB. Correspondingly, in Makassar, South Sulawesi, MDR-TB cases were more likely to have a history of excessive alcohol (Massi et al, 2011).…”

Section: Environmental Factorsmentioning

confidence: 99%

Drug-Resistant Pulmonary Tuberculosis

Putri¹,

Salim²,

Gunawan³

et al. 2023

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Tuberculosis (TB) caused by the pathogenic bacteria Mycobacterium tuberculosis (MTb) still remains a highly prevalent disease, particularly in low and middle-income countries. Due to the bacteria’s atypical cell wall structure, ability to form granuloma, and capacity to switch between replicating and non-replicating states in the host lung parenchyma, the fundamental treatment of patients diagnosed with TB involves a 6-month long daily drug administration. With Indonesia ranking among the nations with the highest TB burden worldwide, there has been an alarming increase of drug-resistant MTb (DR-MTb) strains all over the country in recent years. However, there are currently limited studies available that highlight MTb resistance profiles across different regions within Indonesia. The major risk factors contributing to the emergence and spread of TB in Indonesia include health conditions, environmental conditions, and socioeconomic status. Furthermore, natural compounds and drug repurposing can be employed to combat the further spread of DR-MTb strains across the country, especially in rural regions.

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“…Most of adolescents reported that the have a lot of smokers friends and their parents also smoking. The existence of a cultural relationship with smoking behavior can occur because as explained above that adolescents smoke because of teachings in the family, belief in the benefits of cigarettes as traditional medicine, and smoking habits in daily life which is reinforced by Leininger's theory that says culture can occur if the individual's perspective give rise to belief and value 22 . There are 3 strategies in transcultural nursing namely maintaining culture, cultural negotiation, and changing culture (Leininger in Pratiwi 2011).…”

Section: Disussionmentioning

confidence: 99%

The Relationship among Technology Utilization, Obedience to Law and Smoking Culture In Community with Smoking Behavior in Male Adolescents in Semarang Indonesia

2020

IJFMT

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Background: Smoking behavior in adolescent is still a problem recently. The number continue to increase. This study purpose was to investigate the connectedness of technology utilization, obedience to law, and smoking culture in community with smoking behavior in adolescent in Semarang.Method: This study used cross sectional method. The sample was 104 adolescents with range age 15-17 years old. The sample was chosen using purposive sampling. Data collection using a questionnaire. Four aspects namely demographic data, technology utilization, obedience to law, and smoking culture in community were measured. Those variables the compared to smoking behavior of adolescents. The data then analyzed with Spearman's Rho (α = 0.05).Conlusion: This study found that technology has no significant correlation with smoking behavior (r=0.017; p=0.864). There is significant correlation between obedience to law (r=0.284; p=0.003), and smoking culture in community (r=0.251; p=0.014) with smoking behavior in adolescences. It is necessary for efforts from various parties to overcome smoking behavior in adolescents such as the need for socialization in the community to participate in preventing adolescents who smoke in their environment.

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Effect of smoking and alcohol consumption on pulmonary tuberculosis among Batak ethnic population in Medan, Indonesia

Cited by 4 publications

References 14 publications

Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

Drug-Resistant Pulmonary Tuberculosis

The Relationship among Technology Utilization, Obedience to Law and Smoking Culture In Community with Smoking Behavior in Male Adolescents in Semarang Indonesia

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