Effect of Smoking Cessation on Major Histologic Types of Lung Cancer

Khuder, Sadik A.; Mutgi, Anand B.

doi:10.1378/chest.120.5.1577

Cited by 124 publications

(88 citation statements)

References 50 publications

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“…1,21 Our data (see Table 3) confirm previous reports, indicating that the most powerful smoking relation is to squamous and small cell cancers compared with a less powerful association with adenocarcinoma. 1,21 Data about bronchioloalveolar carcinoma are sparse, but our data are roughly compatible with those in a recent report. 22 Lung cancer cell type preponderance has shifted toward a greater proportion of adenocarcinoma than squamous cell carcinoma.…”

Section: Smokingsupporting

confidence: 89%

“…5 This shift may be due partially to cessation of smoking, which results in greater reduction in incidence of squamous cell and small cell carcinoma than of adenocarcinoma. 21 Lessened tar yield and introduction of filtered cigarettes are possible additional factors in the shift in cell types. 6 Because smoking is a less powerful predictor of adenocarcinoma and bronchioloalveolar carcinoma, additional risk factors presumably play a larger role for these types.…”

Section: Smokingmentioning

confidence: 99%

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Predictors of Lung Cancer: Noteworthy Cell Type Differences

Tran¹,

Siu²,

Li³

et al. 2011

Chest

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Section: Smokingsupporting

confidence: 89%

Section: Smokingmentioning

confidence: 99%

Predictors of Lung Cancer: Noteworthy Cell Type Differences

Tran¹,

Siu²,

Li³

et al. 2011

Chest

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“…1 indicates, patients who stopped smoking after the first cancer diagnosis lived longer than those who continued to smoke. Khuder et al demonstrated that smoking cessation before the first cancer diagnosis reduced the risk of primary lung tumor of all major histologic types and the most significant reduction was observed in the case of small-cell lung carcinoma and squamous cell carcinoma [28]. No unequivocal evidence exists, however, that smoking cessation after lung cancer diagnosis can improve survival rates.…”

Section: Discussionmentioning

confidence: 99%

Impact of smoking on multiple primary cancers survival: a retrospective analysis

2018

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According to available literature, active tobacco smoking enhances the risks of recurrence and development of new primary malignancies. Smoking also shortens the survival period for patients with a diagnosed neoplastic disease. Medical records of 1622 patients hospitalized at the Center for Pulmonary Diseases from January 2013 till March 2017 were retrospectively analyzed, out of which 741 cases with a diagnosis of at least one primary cancer were selected, including 111 patients with multiple primary malignancies. Survival time, the impact of smoking on cancer development and the influence of smoking cessation on the prognosis of the development of new malignancies were analyzed. The incidence of multiple primary malignancies in the population of cancer patients amounted to 14.98%. In the group of smokers, those who ceased smoking developed the second primary malignancy later as compared to those who did not: the period between the first and the new cancer was 11.55 years (SD 7.24) for those who quit smoking, whereas for those who continued to smoke after their first cancer diagnosis it was 6.10 years (SD 8.62) (p = 0.005). It was revealed that patients who had never smoked lived longer than those who had continued to smoke (p = 0.004) and that those who had ceased smoking had a longer survival time than those who had not (p = 0.027). Ceasing smoking after the first cancer diagnosis prolongs the time before a new malignancy develops and is diagnosed, as well as the total survival time after the first cancer diagnosis.

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“…The risk among smokers as compared with those who have never smoked is increased 8-15 times in men and 2-10 times in women and smoking cessation is known to reduce the risk, especially in heavy smokers (3). Cigarette smoke contains several chemicals which are known carcinogens, such as polycyclic aromatic hydrocarbons (PAHs), aromatic amines and N-nitroso compounds.…”

Section: Introductionmentioning

confidence: 99%

Correlation of CYP1A1, GSTP1 and GSTM1 gene polymorphisms and lung cancer risk among smokers

et al. 2012

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Abstract. Lung cancer is the leading cause of cancer mortality worldwide and tobacco smoking has been established as its biggest risk factor. Cigarette smoke contains several carcinogens. Most of them need to be activated by phase I enzymes, such as cytochrome P450 (CYP), while phase II enzymes, such as glutathione S-transferases are responsible for the detoxification of activated forms. The present study aimed to determine the role of CYP1A1, GSTP1 and GSTM1 gene polymorphisms in smoking-related lung cancer risk. It also aimed to investigate the association of the above polymorphisms with clinicopathological parameters, as well as their effect on survival. One hundred newly diagnosed lung cancer patients with advanced disease and 125 healthy controls with a smoking history participated in the study. The participants were screened for the presence of the following polymorphisms: MspI (CYP1A1), Ile105Val (GSTP1) and GSTM1 deletion. The above polymorphisms were also examined with regards to gender, age, histological type and survival. GSTP1 Ile/Val and GSTM1-null genotypes were associated with increased lung cancer risk and the presence of the combination of the three non-wild-type genotypes increases susceptibility to lung cancer (OR 3.328, 95% CI=1.681-6.587, p=0.001). In the non-small cell lung cancer group, the GSTP1 homozygous variant was significantly associated with increased lung cancer risk (p=0.008) and shorter survival. The results of this study suggest that the GSTP1 Ile/ Val genotype and GSTM1 deletion contribute to increased lung cancer susceptibility. Moreover, GSTP1 Val/Val genotype is associated with increased lung cancer risk and shorter survival in non-small cell lung cancer patients.

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Effect of Smoking Cessation on Major Histologic Types of Lung Cancer

Cited by 124 publications

References 50 publications

Predictors of Lung Cancer: Noteworthy Cell Type Differences

Predictors of Lung Cancer: Noteworthy Cell Type Differences

Impact of smoking on multiple primary cancers survival: a retrospective analysis

Correlation of CYP1A1, GSTP1 and GSTM1 gene polymorphisms and lung cancer risk among smokers

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