Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex

Dervişoğulları, Mehmet Serdar; Totan, Yüksel; Tenlik, Aylin; Yüce, Aslıhan; Güler, Emre

doi:10.3109/15569527.2014.975240

Cited by 48 publications

(34 citation statements)

References 26 publications

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“…Potential biologic explanations could be reduced axonal flow or axonal swelling in the course of axonal degeneration due to intake of neurotoxins and cytotoxins from cigarette smoke. However, our results are in contrast with findings of earlier studies 27,28 , which reported reduced pRNFLT in smokers. Suggested mechanisms leading to decreased pRNFLT were toxic damage through free radicals, increased IOP and reduced perfusion [27][28][29] .…”

Section: Discussioncontrasting

confidence: 99%

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

et al. 2018

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Section: Discussioncontrasting

confidence: 99%

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

et al. 2018

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“…Although Dervişoğulları et al [20] stated that the nasal, temporal, and central retinal thickness did not differ significantly between smokers and control groups, they proved that the mean RNFL was significantly thinner in the smokers group compared to that in the controls (inferior and superior quadrants of RNFL decreased in smoker group but temporal and nasal quadrants did not seem to be changed [21], which is in agreement with our reports.…”

Section: Discussionsupporting

confidence: 92%

Effect of Active and Passive Smoking on Retinal Nerve Fibre Layer and Ganglion Cell Complex

El-Shazly

Farweez

Elewa

et al. 2017

Journal of Ophthalmology

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Aim. To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG). Materials and Methods. We include 80 active chronic smokers and 80 age- and sex-matched healthy passive smokers. After a full ophthalmological examination, SD-OCT and PERG were tested for all participants. Urinary levels of cotinine and creatinine with subsequent calculation of the cotinine creatinine ratio (CCR). Results. Inferior and superior quadrants of RNFL were thinner in group I, but nasal and temporal quadrants did not show significant difference between the groups. There were no significant differences of GCC values between the two groups. There was no significant difference of PERG-P50 amplitude and latency; however, PERG-N95 showed significant difference between the two groups. Multiple regression analyses demonstrated that the number of cigarettes/day, urinary cotinine, and PERG-N95 amplitude are the most important determinants for both superior and inferior RNFL thicknesses. Conclusion. RNFL thickness decreases in chronic, healthy, heavy cigarette smokers, and this thinning is related to the number of cigarettes/day, urinary cotinine, and PERG-N95 latency and amplitude.

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“…These findings concur with the published data by Dervişoğulları et al, 18 they demonstrated that the average RNFL was significantly thinner in smokers compared with non-smokers. Also, measurements of superior and inferior quadrants were significantly reduced in smoker cases, with no significant changes in temporal or nasal quadrants.…”

Section: Figuresupporting

confidence: 93%

<p>Functional and Structural Changes of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Heavy Smokers</p>

Abdelshafy¹,

Abdelshafy²

2020

OPTH

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Purpose: To assess the functional and structural changes in the retinal nerve fiber layer (RNFL) and the ganglion cell complex (GCC) in heavy smokers using pattern electroretinogram (PERG), photopic negative response(PhNR) and spectral domain optical coherence tomography (SD-OCT). Patients and Methods: Sixty eyes of 30 heavy smokers (at least 15 cigarettes/day for 10 years) (study group) and 60 eyes of 30 age and gender-matched healthy non-smoker subjects (control group) were included. After full ophthalmologic examination (PERG), (PhNR) using RETI-port/scan 21 (Roland Consult, Brandenburg, Germany) and (SD-OCT using Topcon 3D OCT model 2000 FA version.8.30) were tested for all participants. Statistical analysis was performed to compare GCC, RNFL thicknesses, PERG and phNR values between groups. Results: The mean age was 36.67±4.13 years in the study group and 36.0±4.76 years in the control group. There were no statistical significant differences between the two groups regarding intraocular pressure (p=0.43), axial length (p=0.37), and central corneal thickness (p=0.86). There were significant differences of GCC thickness values between the study group (88.4±6.6 µm) and control group (94.83±5.25 µm) (p<0.001). The mean RNFL values of study and control groups were 97.87±5.88 and 106.43±6.59 µm, respectively (p<0.001). In the study group the superior and inferior quadrants of RNFL were significantly thinner, but there were no significant differences between the two groups in nasal and temporal quadrants. There were no significant differences of PERG-P50 amplitude (p=0.49) and latency (p=0.71); however, PERG-N95 amplitude and latency showed significant differences between the two groups (p<0.001).There were significant differences of phNR amplitude and latency between the two groups (p<0.001). Multiple regression analyses demonstrated that the PhNR, PERG amplitude and latency are the most important determinants for both RNFL and GCC thicknesses. Conclusion: In heavy smokers RNFL thickness was decreased, the PhNR, PERG-N95 amplitudes were diminished and the implicit times were prolonged compared to non-smokers. PhNR and PERG reflect both dysfunction and loss of ganglion cells and their axons.

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Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex

Abstract: Smoking may affect RNFL thickness but not GCIPL.

Cited by 48 publications

References 26 publications

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Effect of Active and Passive Smoking on Retinal Nerve Fibre Layer and Ganglion Cell Complex

<p>Functional and Structural Changes of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Heavy Smokers</p>

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