Effect of Smoking on Sperm Vitality, DNA Integrity, Seminal Oxidative Stress, Zinc in Fertile Men

Taha, Emad A.; Ez-Aldin, Azza M.; Sayed, Sohair K.; Ghandour, Nagwa; Mostafa, Taymour

doi:10.1016/j.urology.2012.07.002

Cited by 99 publications

(66 citation statements)

References 26 publications

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“…Increased OxS levels were associated also with male genital tract inflammation as has been revealed also by previous studies [39,40]. Other studies have shown that smokers have higher level OxS [41] and that was revealed also in our study. This is one of the mechanisms by which smoking may have an adverse impact on fertility and also ART outcome.…”

Section: -Epi (8-iso Prostaglandin F 2α ) 8-ohdg (8-hydroxy-2'-deoxsupporting

confidence: 92%

Systemic oxidative stress could predict assisted reproductive technique outcome

Ahelik

Mändar

Korrovits

et al. 2015

J Assist Reprod Genet

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Purpose Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART). Methods Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded. Results Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner's state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97, 8±16,7 vs 72.9±22,9, p=0.007; in men, 89.6±20,4 vs 72,1± 22,6, p=0.049). Conclusions To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.

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Section: -Epi (8-iso Prostaglandin F 2α ) 8-ohdg (8-hydroxy-2'-deoxsupporting

confidence: 92%

Systemic oxidative stress could predict assisted reproductive technique outcome

Ahelik

Mändar

Korrovits

et al. 2015

J Assist Reprod Genet

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“…We observed a significant lower level of omentin-1 in semen samples of cigarette smokers compared with nonsmokers concomitant with significant lower sperm count and progressive motility percentage and significant higher DFI and seminal ROS level. These findings are supported by the current dogma that the persistent oxidative burden caused by smoking can generate secondary mediators which may induce inflammation [26] .…”

Section: Discussionmentioning

confidence: 53%

Omentin-1 in serum and seminal plasma correlate with semen quality

et al. 2017

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Introduction: Adipokines are differently regulated in the male reproductive tract and they were reported to affect sperm functionality. Serum omentin-1 was reported to have a range of effects on various cell types. Aim: To explore the presence of omentin-1in human semen, to investigate its relation with semen parameters in both fertile and infertile men and to compare its serum and seminal plasma levels in particular conditions such as; smoking, varicocele and leukocytospermia. Methods: Thirty nine infertile and 26 fertile men were enrolled in this case control study. They were subjected to history taking, clinical/physical examination, semen analysis, and measurement of omentin-1 in serum and seminal plasma, DNA fragmentation index (DFI) and seminal reactive oxygen species (ROS). Results: Omentin-1 was detected in all analyzed semen and serum samples (n=65). The concentration of omentin-1 was significantly higher in seminal plasma than in serum. Serum and seminal omentin-1 were positively correlated with sperm concentration and percentage of progressive motility and were negatively correlated with percentage of abnormal forms, DFI and ROS. The mean seminal plasma level of omentin-1 was significantly decreased in smokers and in patients with leukocytospermia. The mean serum level of omentin-1 was significantly decreased in patients with varicocele. Both serum and seminal omentin-1 levels were significantly lower in infertile patients than fertile men. Conclusions: Semen and serum Omentin-1 correlate with semen quality. In cases of leukocytospermia and smoking, seminal omentin-1 concentrations were decreased, suggesting that it may play a regulatory role in inflammation of the male reproductive system.

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“…The prime component of tobacco is nicotine, which is a well-known ROS producer in spermatozoa with detrimental effects on the sperm count, motility and morphology. Moreover, smokers exhibited a lower hypo-osmotic swelling test percentage, indicating a weaker plasma membrane integrity when compared to non-smokers [41]. Smoking increases ROS production by causing leukocytospermia as shown by Saleh et al [42], who also demonstrated that in smokers, the seminal ROS and total antioxidant capacity score was increased-a direct indication of oxidative imbalance in affected ejaculates.…”

Section: External Sources Of Rosmentioning

confidence: 90%

“…Cigarettes contain a broad array of free radical-inducing agents such as nicotine, cotinine, hydroxycotinine, alkaloids and nitrosamines [41,42]. The prime component of tobacco is nicotine, which is a well-known ROS producer in spermatozoa with detrimental effects on the sperm count, motility and morphology.…”

Section: External Sources Of Rosmentioning

confidence: 99%

Physiological and Pathological Roles of Free Radicals in Male Reproduction

Tvrdá¹,

Massányi²,

Lukáč³

2018

Spermatozoa - Facts and Perspectives

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Oxidative stress (OS) is a condition caused by an imbalance between reactive oxygen species (ROS) overgeneration and decreased antioxidant defense mechanisms in the cell. OS has become a prominent factor in male reproductive dysfunction as ROS cause damage to sperm DNA, lipids and proteins, alterations to critical sperm structures and signaling pathways, leading to a decreased sperm activity and fertilizing capacity. At the same time, small amounts of ROS play vital roles in events leading to sperm maturation and acquisition of functional activity, which is why a proper oxidative balance is of paramount importance for a proper male fertility. Understanding the physiological and pathological roles of ROS in male reproduction has become an essential pillar of modern andrology; however, numerous questions related to the controversial behavior of ROS in male reproductive cells and tissues still remain unanswered. This chapter aims to summarize current evidence available on the relationships between free radicals, antioxidants and male reproduction and to trigger more scientific interest, particularly with respect to the design of efficient strategies to diagnose or treat male sub-or infertility associated with OS.

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Effect of Smoking on Sperm Vitality, DNA Integrity, Seminal Oxidative Stress, Zinc in Fertile Men

Cited by 99 publications

References 26 publications

Systemic oxidative stress could predict assisted reproductive technique outcome

Systemic oxidative stress could predict assisted reproductive technique outcome

Omentin-1 in serum and seminal plasma correlate with semen quality

Physiological and Pathological Roles of Free Radicals in Male Reproduction

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