Effect of social isolation on the metabolism of morphine and its passage through the blood-brain barrier and on consumption of sucrose solutions

Coudereau, Jean-Pierre; Stain, Frédérique; Drion, N.; Sandouk, P.; Monier, Claire; Debray, Marcel; Scherrmann, Jean‐Michel; Bourre, Jean‐Marie; Frances, Henriette

doi:10.1007/s002130050994

Cited by 12 publications

(7 citation statements)

References 37 publications

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“…We also observed that adding sucrose to the drinking water, in the absence of analgesic drugs did not increase water consumption (Supplementary File 1A,E). This seems to contradict publications that demonstrated that mice prefer to drink sweetened water [48,61,62]. The C57Bl/6J mouse strain was reported to be especially susceptible to sweetened water, when compared to other mouse strains [46,47].…”

Section: Discussionmentioning

confidence: 68%

Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis

Tang

Nierath

Palme

et al. 2020

Animals

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Pain management during in vivo experiments is an animal welfare concern and is in many countries also legally required. In this study, we evaluated C57Bl/6J mice when 3 g/L metamizole or 1 g/L tramadol was provided via drinking water, before and during cerulein-induced chronic pancreatitis. Supplementation of drinking water with metamizole or tramadol did not significantly reduce the amount of consumed water. In order to evaluate the wellbeing of mice, a distress score, burrowing activity, nesting behavior, and body weight was assessed. Before induction of pancreatitis, neither tramadol nor metamizole influenced these readout parameters. Chronic pancreatitis caused a significantly increased distress score, decreased burrowing activity and a reduction in body weight. Mice drinking tramadol-supplemented water experienced less loss in body weight and consumed more water than mice drinking metamizole, at a few time-points during chronic pancreatitis. Pancreatic atrophy, a characteristic feature of chronic pancreatitis was not differentially influenced by either analgesic. In conclusion, both analgesics can be used during 33 days of chronic pancreatitis, but tramadol seems to be moderately advantageous when compared to metamizole.

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Section: Discussionmentioning

confidence: 68%

Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis

Tang

Nierath

Palme

et al. 2020

Animals

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“…(1997) had shown that morphine CPP was observed in social mice at the dose of 8 mg/kg, whereas 4 weeks of isolation impaired morphine (8–100 mg/kg ip) place conditioning. In a follow‐up to this study, Coudereau et al . (1999) further investigated this phenomenon and tested three possible explanations: a reduced sensitivity to reinforcers induced by isolation; a difference in morphine disposition in isolated and social mice; and an altered blood–brain barrier transport of morphine in isolated mice.…”

Section: Methodological Issuesmentioning

confidence: 72%

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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Conditioned place preference (CPP) continues to be one of the most popular models to study the motivational effects of drugs and non-drug treatments in experimental animals. This is obvious from a steady year-to-year increase in the number of publications reporting the use this model. Since the compilation of the preceding review in 1998, more than 1000 new studies using place conditioning have been published, and the aim of the present review is to provide an overview of these recent publications. There are a number of trends and developments that are obvious in the literature of the last decade. First, as more and more knockout and transgenic animals become available, place conditioning is increasingly used to assess the motivational effects of drugs or non-drug rewards in genetically modified animals. Second, there is a still small but growing literature on the use of place conditioning to study the motivational aspects of pain, a field of pre-clinical research that has so far received little attention, because of the lack of appropriate animal models. Third, place conditioning continues to be widely used to study tolerance and sensitization to the rewarding effects of drugs induced by pre-treatment regimens. Fourth, extinction/reinstatement procedures in place conditioning are becoming increasingly popular. This interesting approach is thought to model certain aspects of relapse to addictive behavior and has previously almost exclusively been studied in drug self-administration paradigms. It has now also become established in the place conditioning literature and provides an additional and technically easy approach to this important phenomenon. The enormous number of studies to be covered in this review prevented in-depth discussion of many methodological, pharmacological or neurobiological aspects; to a large extent, the presentation of data had to be limited to a short and condensed summary of the most relevant findings.

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“…Group-housed and singly housed rodents have been found to differ with respect to behavioral and neurochemical effects of drugs. Singly housed rodents tend to be more sensitive than grouphoused rodents to certain drugs (e.g., Cheeta et al 2001;Coudereau et al 1999). Furthermore, defeated or subordinate rodents differ in sensitivity to drugs compared to residents or dominant rodents.…”

Section: Introductionmentioning

confidence: 99%

Housing and rank status of male Long–Evans rats modify ethanol’s effect on open-field behaviors

Pohorecky

2006

Psychopharmacology

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Effect of social isolation on the metabolism of morphine and its passage through the blood-brain barrier and on consumption of sucrose solutions

Abstract: We conclude that the behavioural effect of isolation observed in the conditioned place preference to morphine may depend on changes both in morphine disposition and in the sensitivity to reinforcers in isolated mice.

Cited by 12 publications

References 37 publications

Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis

Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Housing and rank status of male Long–Evans rats modify ethanol’s effect on open-field behaviors

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