Effect of SOD1 overexpression on age- and noise-related hearing loss

Expression of Antioxidant Genes in the Mouse Cochlea and Brain in Salicylate-Induced Tinnitus and Effect of Treatment with <b><i>Spirulina platensis</i></b> Water Extract

“…Previously, oxidative stress damage was widely believed to be one of the most important mechanisms in many neurodegenerative diseases, including age-related hearing impairment [Coling et al, 2003;Hwang et al, 2012;Keithley et al, 2005;Seidman, 2000], Alzheimer's disease [Liu and Mori, 1993], and Parkinson's disease [Choi, 1993]. However, the role of oxidative stress in tinnitus had not been well documented.…”

Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-l-carnitine

“…The injured mitochondria in turn produce relatively more ROS further accentuating the damage (Lenaz et al, 1998;Poderoso et al, 2000). Mitochondrial injury is a critical factor in NIHL resulting from excessive ROS generation within mitochondria or from glutamate excitotoxicity or GSH depletion (Hyde and Rubel, 1995;Kroemer, 1999;Kroemer and Reed, 2000;Kopke et al, 2002;Coling et al, 2003;Fischel-Ghodsian et al, 2004). It is suggested that ALCAR protect mitochondria from oxidative stress by maintaining normal electron transport and reducing ROS production by way of its effects on the mitochondrial membrane.…”

The Effects of Noise on Hearing and Oxidative Stress in Textile Workers

“…If the free radicals produced by oxidative stress are not balanced by an antioxidant defence system, then they may lead to various damages in tissues. SOD and CAT are two of the endogenous antioxidants in the body 19,20) .…”