Effect of Sodium Cobaltinitrite on the Minimal Carcinogenic Dose50 (MCD50) of Methylcholanthrene in Albino Mice

Effect of Sodium Nitrite and p-Aminopropiophenone on the Minimal Carcinogenic Dose50 of Methylcholanthrene on Mouse Epidermis

“…A previous paper reported that the biweekly injection of sodium cobaltinitrite in doses of 50 to 80 mg./Kg. in mice subjected to the M C D~O of methylcholanthrene resulted in a significant reduction of tumor incidence compared to controls (6). Methemoglobin determinations confirmed that sodium cobaltinitrite produced transient periods of methemoglobinemia.…”

“…A previous paper reported that periodic injections of sodium cobaltinitrite, a methemoglobinforming agent, were capable of reducing significantly the incidence of epidermal tumors in mice subjected to the minimal carcinogenic dose50 (MCD5o) of methylcholanthrene (6). Therefore, the possibility existed that hypoxia, a result of the formation of methemoglobinemia, was a causative factor in the reduction of the tumor incidence.…”

Apparent Enzyme Inhibition Through Enzyme-Induction Studies as a Possible Mode of Action of Certain Cobalt Compounds

“…During the past decade, much enthusiasm has been gensrated concerning the modification, by chemical n-ieans, of the complex processes of carcinogenesis and cleft palate inception (1)(2)(3)(4). Out of a myriad of investigations concerned with the blocking of these two different pathological processes, one finds that cobaltous chloride and sodium cobaltinitrite used alone in the proper amount and time are both successful in reducing the incidence of methylcholanthrene-induced tumors and cortisone-induced cleft palate (1,3).…”

“…Out of a myriad of investigations concerned with the blocking of these two different pathological processes, one finds that cobaltous chloride and sodium cobaltinitrite used alone in the proper amount and time are both successful in reducing the incidence of methylcholanthrene-induced tumors and cortisone-induced cleft palate (1,3). In addition, by themselves, cobaltous chloride and sodium cobaltinitrite both were shown to cause a low incidence of cleft palate.…”