Effect of Sodium Lactate Infusion on Urate Clearance in Man.

Abstract

809 no effect on the surface or caused the appearance of a watery fluid, which could be drained off. Whether this fluid was a condensation of water molecules from the air or represented an actual secretion is not known. The mucous layer of control tissue had a glossy appearance, but was never watery.5 . EBect on Ciliary Resistance to Mechanical Trauma. It was noted that positive ions rendered the cilia peculiarly vulnerable to mechanical trauma. A single, very gentle stroke with a cotton-tipped swab dipped in Ringer's solution, which had no lasting effect on the control, completely stopped ciliary activity over all or most of the surface of the tissue receiving positive ions, This enhanced vulnerability completely disappeared when the tissue was exposed to negative ions. It also disappeared if the tissue was allowed to stand in the control chamber for an hour or more.It is not at all obvious on a priori grounds that air ions should possess any capacity to influence biological systems. Nevertheless, evidence is collecting which establishes such activity in several areas. For example, positive ions reduce the succinoxidase content of the rat adrenal gland(4), and negative ions raise the COZ combining power of hamster blood plasma( 7). During the past 2 years we studied the response of microorganisms sus-pended in very small drops of water when exposed to positive and negative air ions and have secured quantitatively reproducible alterations in survival curves ( 3 ) .While we have as yet developed no theory to account for the action of air ions on the rabbit trachea, it is possible that some of the changes we noted in the rate of water evaporation from droplets containing bacteria (3) may have significance here as well. A study of the inter-relationships and possible interdependence of the effects described in this series of experiments is currently in progress.Gibson and Doisy( 1 ) made the interesting observation, in normal human subjects, that ingestion of sodium lactate results in a striking if transitory decrease in the urinary excretion of uric acid, accompanied by a slight rise in plasma uric acid, suggesting "an elevated threshold in the kidney." Quick (2 ) , Michael ( 3 ) and Nichols et aL(4) confirmed the de-

Interrelation of Uric Acid and Ethanol Metabolism in Man*

“…These effects have been attributed to the rise in blood lactate, since lactate administration is known to decrease urinary uric acid excretion (27)(28)(29). Thus, it appears reasonable to assume that the rise in serum uric acid concentration and the concomitant decrease in urinary uric acid output, which we observed in patients given ethanol, resulted, at least in part, from the rise in blood lactate.…”

“…In the present and in previous studies investigating the effect of lactate on renal uric acid excretion (28,29), the R, racemic, form has been administered, but in mammalian species, L-lactate is preferentially metabolized (30,31). Since the chemical method used (7) measures both D-and L-lactate, and since the relative proportions of the two isomers in the blood and their respective effects on uric acid excretion are unknown, it is difficult to relate blood lactate values to urinary urate excretion quantitatively.…”

Uric Acid Metabolism in Therapy of Glycogen Storage Disease Type I

“…excretion (5,25). However, Fine et al (4) have noted that infusion of glucose in affected patients increases renal uric acid an expression used is your nose with a rubber hose.,, hi^ excretion before lactic acid levels fall, perhaps by providing an was their basis for refusing the nasogastric tube and the research.…”

Purine and pyrimidine metabolism

“…However, nutritionally more important is the profound influence of changes in the NAD/NADH ratio and the presence of vitamin K antagonists such as dicoumarol (Zollner & Grobner, 1969). Ketoacids, whether due to fasting or bad control of diabetes, inhibit uric acid excretion as does the ingestion of large amounts of ethanol, producing lactacidosis (Yu et al 1957;Lieber et al 1962).…”