Effect of sodium loading and depletion on vascular reactivity and prostacyclin generation.

Yoshimura, Manabu; Kaimasu, Isao; Kitani, Teruo; Kawamura, Tsunehiro; Takeda, Kazuo; Sasaki, Susumu; Kajita, Yoshihiro; Nakagawa, Masao; Ijichi, Hamao

doi:10.1253/jcj.44.388

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…The comparison of these data with the PGI2 generation rates obtained from the animals on the normal rat chow (group 111) illustrates that the effect of changes in dietary NaCl on rat aorta PGI2 generation occurs between the normal intake of 0.8 mmol day-' and the 6.4 mmol day-' achieved during saline loading. Somewhat different results on the dependence of rat aorta PGI2 generation on the state of sodium balance were obtained by Yoshimura et al [24]. In this study, an increase in PGI2 synthesis during dietary NaCl restriction is described.…”

Section: Discussionmentioning

confidence: 48%

Sodium balance as a determinant of prostacyclin production by isolated rat aorta

Düsing

Landsberg

Pietsch

et al. 1987

Eur J Clin Investigation

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The present study investigates whether the synthesis of prostacyclin (PGI2) in isolated rat aorta is dependent on the state of sodium balance of the animals. Three groups of ten rats each were included into the study. Two of them were fed a diet low in NaCl for 10 days with group I receiving 0.9% saline and group II distilled water as drinking fluid. Group III received a regular rat chow containing approximately 0.8 mmol day-1 of sodium, also for 10 days. At the end of the dietary protocol, systolic arterial blood pressure was significantly higher in group I (109.9 +/- 2.4 mmHg) as compared to group II (101.0 +/- 2.4 mm Hg; P less than 0.05) and group III animals (102.2 +/- 1.6 mm Hg; P less than 0.05). Generation of PGI2-like activity was determined in portions of the animals' isolated aorta using a platelet aggregation bioassay following incubation in 0.05 M Tris buffer (pH 9.3) for 12, 15, and 30 min, respectively. During these incubation times, generation of PGI2-like activity averaged 48.6 +/- 3.5, 57.8 +/- 4.3 and 68.3 +/- 3.2 pmol mg-1 in group III animals, which had received the regular rat chow, with similar values in the low salt group II (50.2 +/- 2.5, 57.7 +/- 2.7 and 72.9 +/- 3.7 pmol mg-1). Aortic generation of PGI2-like material was significantly suppressed in the high salt group I (37.5 +/- 2.8, 46.2 +/- 3.2 and 61.3 +/- 4.0 pmol mg-1; P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 48%

Sodium balance as a determinant of prostacyclin production by isolated rat aorta

Düsing

Landsberg

Pietsch

et al. 1987

Eur J Clin Investigation

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“…We have previously observed an enhanced pressor response to norepinephrine at the sufficient load of sodium in animal experiments . 15) Since the pressor response to norepinephrine is modulated by prostaglandins (PG), it is increased in cases with PG deficiency and decreased in cases with augmented PG. It was reported that the NSS patients excrete more urinary prostaglandin E2 (PGE2) during sodium depletion than the SS pa-tients.6) The enhanced excretion of PGE2 in the urine of NSS patients suggests the possibility that the biosynthesis of PG in various tissues may be enhanced in the NSS patients.…”

Section: Discussionmentioning

confidence: 99%

Enhanced vascular reactivity to norepinephrine in salt-sensitive patients with hypertension.

et al. 1982

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SUMMARYTwenty patients with hypertension were studied under diets containing low and high salt to identify factors which might be involved in elevating blood pressure under sodium-loading. They were classified as "salt-sensitive" (SS) and "nonsalt-sensitive" (NSS) according to the presence or absence of greater than 10% increases in mean blood pressure when a low salt diet was replaced by a high salt diet. During high-sodium intake, the SS patients showed reduced urinary excretion of sodium and elevated plasma levels of aldosterone as compared with plasma renin activity. The SS patients also showed an enhanced pressor response to norepinephrine under both low-sodium and high-sodium diets.From these results, it is suggested that the sodium retention, which is probably related to nonsuppressed levels of PAC under sodium-loading, is one of the factors in elevating blood pressure in the SS patients. Moreover, the enhanced pressor response to norepinephrine seems to contribute, in part, to elevation of blood pressure in the SS patients under salt-loading.Additional Indexing Words: Salt-sensitive hypertension Nonsalt-sensitive hypertension Pressor response Norepinephrine Renin-aldosterone HE major effects of dietary salt on incidence of hypertension1) and development of hypertension2) have been investigated in a number of epidemiological and experimental studies. It has been proposed that the expansion of the extracellular fluid volume by salt-loading is an important event in the elevation of blood pressure and the development of hypertension.3) How-

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Milk prostaglandins and electrical conductivity in bovine mastitis

Atroshi¹,

Parantainen²,

Kangasniemi

et al. 1987

Veterinary Research Communications

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Prostaglandin (PG) levels in milk samples from healthy and mastitic cows were determined by radioimmunoassay. In composite milk the PG levels were rather high both in healthy and mastitic samples, and the only significant difference was in thromboxane B2 (TXB). In quarter milk samples classified according to the degree of mastitis by use of somatic cell counts, PGE2 was 40, PGF2 alpha 15, and TXB2 44 per cent higher respectively in affected samples. PG levels were in good correlation with somatic cell counts (r = 0.63-0.68, p less than 0.01) and electrical conductivity (r = 0.36-0.52, p less than 0.01), two established criteria for diagnosis of mastitis. PGE2 also correlated with protein, TXB2 with fat content. PGF 2 alpha was in a negative correlation with milk yield. The good correlation of PGs with somatic cell counts and electrical conductivity suggests that PGs might be used as markers of mastitic inflammation.

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Effect of sodium loading and depletion on vascular reactivity and prostacyclin generation.

Cited by 8 publications

References 11 publications

Sodium balance as a determinant of prostacyclin production by isolated rat aorta

Sodium balance as a determinant of prostacyclin production by isolated rat aorta

Enhanced vascular reactivity to norepinephrine in salt-sensitive patients with hypertension.

Milk prostaglandins and electrical conductivity in bovine mastitis

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