Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation

Fan, Ting; Xiang, Meng-Ya; Zhou, Ruo-Qiao; Li, Wen; Wang, Liqin; Guan, Ping; Li, Geng-Lin; Wang, Yunfeng; Li, Jian

doi:10.1007/s12264-021-00747-z

Cited by 4 publications

(5 citation statements)

References 46 publications

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“…As mentioned, SS at the tinnitus-inducing dose can damage IHCs and the transmission of optoacoustic pressure wave can be disrupt due to the damaged IHCs. 24 Therefore, our results con rm the optoacoustic effect as the main mechanism of optoacoustic stimulation, in which healthy hair cells are required for the pressure wave transmission.…”

Section: Discussionsupporting

confidence: 72%

“…25 It has been reported that the tinnitus-inducing dose of SS can causes cochlear synaptopathy and loss of connections between IHCs and afferent auditory nerve bers. 24,28 On the other hand, it has been indicated that in animal models of hidden hearing loss caused by aging or noise trauma, synapses between IHCs and auditory nerve bers are permanently lost, but sensitivity to quiet sounds remains unchanged. 29 The pre-pulse in the PPI test, is a short duration noise burst with the same amplitude as the background sound, so a normal PPI ratio despite an increased ABR threshold may be due to remaining the sensitivity to quiet sounds.…”

Section: Discussionmentioning

confidence: 99%

“…23 On the other hand, exposure to a high dose of SS has been reported to result in signi cant damage to cochlear inner hair cells (IHCs). 24 In most cases, tinnitus is associated with hearing loss, but in some cases, tinnitus is associated with "hidden hearing loss" caused by cochlear synaptopathy. Clinically, these people have normal hearing, but they have problems in noisy environments.…”

Section: Introductionmentioning

confidence: 99%

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Acoustic and Optoacoustic Stimulations in Auditory Brainstem Response test in Salicylate Induced Tinnitus

Montazeri

Farhadi

Akbarnejad

et al. 2023

Preprint

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As a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by Sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acoustic and Optoacoustic Stimulations in Auditory Brainstem Response test in Salicylate Induced Tinnitus

Montazeri

Farhadi

Akbarnejad

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The decrease of the amplitude of wave II and increase in threshold after tinnitus induction indicated the important role of hair cells in optoacoustic stimulation. As mentioned, SS at the tinnitus-inducing dose can damage IHCs and the transmission of optoacoustic pressure wave can be disrupt due to the damaged IHCs 36 . Therefore, our results confirm the optoacoustic effect as the main mechanism of optoacoustic stimulation, in which healthy hair cells are required for the pressure wave transmission.…”

Section: Discussionmentioning

confidence: 95%

“…This decrease in neural output subsequently returns to normal at the level of the brainstem 35 . It has been reported that the tinnitus-inducing dose of SS can causes cochlear synaptopathy and loss of connections between inner hair cells (IHCs) and afferent auditory nerve fibers 36 , 37 . On the other hand, it has been indicated that in animal models of hidden hearing loss caused by aging or noise trauma, synapses between IHCs and auditory nerve fibers are permanently lost, but sensitivity to quiet sounds remains unchanged 38 .…”

Section: Discussionmentioning

confidence: 99%

Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus

Montazeri¹,

Farhadi²,

Akbarnejad³

et al. 2023

Sci Rep

View full text Add to dashboard Cite

As a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus.

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Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling

Wang,

Sun,

Yang

et al. 2023

J Orthop Surg Res

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Background Eccentric muscle contraction can cause muscle damage, which reduces the efficiency of exercise. Previous evidence suggested that Sodium salicylate (SS) could improve the repair of aged muscle. This study intends to investigate whether SS can impact skeletal muscle damage caused by eccentric exercise. Methods Eccentric treadmill exercise was performed to induce muscle damage in mice. Plasma levels of muscle damage markers were estimated. RT-qPCR was employed for detecting mRNA levels of proinflammatory mediators in murine gastrocnemius muscle. Immunofluorescence staining of laminin/DAPI was utilized for quantifying centrally nucleated myofibers in the gastrocnemius muscle. Western blotting was implemented to examine protein levels of mitsugumin 53 (MG53), matrix metalloproteinase (MMP)-2/9, and NF-κB signaling-related markers. Results SS administration reduced muscle damage marker production in the plasma and decreased the levels of proinflammatory mediators, MG53 and MMP-2/9 in mice after exercise. SS alleviated the severity of muscle damage in the gastrocnemius of mice after eccentric exercise. SS blocked NF-κB signaling pathway in the gastrocnemius muscle. Conclusion SS administration ameliorates skeletal muscle damage caused by eccentric exercise in the mouse model.

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Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation

Cited by 4 publications

References 46 publications

Acoustic and Optoacoustic Stimulations in Auditory Brainstem Response test in Salicylate Induced Tinnitus

Acoustic and Optoacoustic Stimulations in Auditory Brainstem Response test in Salicylate Induced Tinnitus

Acoustic and optoacoustic stimulations in auditory brainstem response test in salicylate induced tinnitus

Sodium salicylate ameliorates exercise-induced muscle damage in mice by inhibiting NF-kB signaling

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