In the rice-wheat rotation system, conventional culturing of high yield rice results in poor soil conditions and excessive residues, which negatively affect wheat growth. Tillage and nitrogen (N) use are being sought to address this problem. In order to propose a suitable tillage method and corresponding N management strategy, the influence of three tillage methods (i.e., plow tillage followed by rotary tillage (PR), rotary tillage twice (RR), and no-tillage (NT)) and nine forms of N management strategies (i.e., three total N rates × three N-splitting schemes) were investigated in a field experiment from 2016 to 2017 (2017) and 2017 to 2018 (2018), using grain yield, grain protein content (GPC), N uptake efficiency (NUpE), and net returns as evaluation indexes. Grain yield, GPC, and net returns were lower in 2017 than 2018, likely as a result of weak seedling growth caused by high soil moisture before and after seeding. In 2017, NT achieved higher grain yield, NUpE, and net returns compared to PR or RR, while grain yield and net returns were higher under tillage in 2018, especially PR. Increased total N rates (210–270 kg ha−1) promoted all evaluation indexes, but suitable timing and corresponding rates of N application are dependent on the environment. These results indicate that the combination of NT and applying N at lower rates and only a few times (i.e., 168 and 72 kg ha−1 applied at pre-sowing and when flag leaves are visible) when the soil is not suitable for tillage is the best method for cutting costs and improving benefits. Under suitable conditions for tillage, PR and intensive management strategies (i.e., 135, 27, 54, and 54 kg ha−1 applied at pre-sowing, four-leaf, jointing, and booting, respectively) could be adopted to increase overall yield, quality, and benefits.