Effect of solubilisation on the antibacterial activity of hexachlorophane

Abstract

Macrogol Polyethylene polypropylene glycol Effect of solubilisation on the antibacterial activity Hard Macrogol, B.P.C. ; Polyethylene glycol 4000; Oxyethylene-oxypropylene polymer; Pluronic F 68 Union Carbide Wyandotte Chemicals Carbowax 4000Corp.The solubilisation of hexachlorophane by various non-ionic agents has been studied at p H 2.5 and 8.0. The interaction of the phenol with these agents in unsaturated systems at pH 8.0 has been determined by a dialysis technique using rubber latex membranes. The bactericidal activity is shown to depend on the concentration of unbound hexachlorophane, but this is not simply related to the degree of saturation of the total system. The results of agar-plate diffusion tests cannot be correlated with either the concentration of unbound hexachlorophane or the total concentration.ANY phenolic antiseptics have a low water solubility and because M of this are often used together with surface-active agents which