Effect of soluble glass bolus administration on the blood selenium concentration in grazing Philippine goats under backyard conditions

Hayashida, Minoru; Orden, Edgar A.; Cruz, E.M.; Cruz, Libertado C.; Fujihara, Tsutomu

doi:10.1111/j.1740-0929.2006.00391.x

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…Although Se concentrations in group Se-Y exceeded 200 μg/l, the animals showed no signs of toxicity. Similarly to our results, other authors did not observe toxicity in goats with Se concentrations of above 200 μg/l (Hayashida et al 2006;Pechova et al 2008). The activity of glutathione peroxidase in blood strongly correlated with Se concentration in whole blood.…”

Section: Discussionsupporting

confidence: 91%

The effect of various forms of selenium supplied to pregnant goats on selected blood parameters and on the concentration of Se in urine and blood of kids at the time of weaning

Pechová¹,

Sevcikova²,

Pavlata³

et al. 2012

Vet. Med. - Czech

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ABSTRACT:The aim of this trial was to compare the effect of supplementation of goats with different forms of selenium on the metabolism of their kids at the time of weaning. The experiment was performed with 45 kids of mothers supplemented with various forms of selenium. Group C was control while the other four groups were supplemented with selenium for six weeks before (0.3 mg/goat/day) and after parturition (0.9 mg/goat/day). Group Se-I received sodium selenite while the other groups received organic forms: Se-lactate-protein complex (Se-L), Se-proteinate (Se-P) and Se-yeast (Se-Y). The kids were weaned at three months of age and samples of blood and urine were taken. Parameters monitored in the blood included Se, glutathione peroxidase (GPx), Zn, Cu, thyroxine, triiodothyronine, protein, immunoglobulins, muscle enzymes, total antioxidant status, vitamin A and E. Se levels were determined In the urine. Selenium supplementation of goats from six weeks before delivery significantly influenced selenium concentrations in the blood of kids. Significant differences (P < 0.0002) were found between the control and all experimental groups and further between Se-Y and the other experimental groups (Se-Y: 243.0 ± 20.3 μg/l; Se-I: 156.3 ± 34.3 μg/l; Se-P: 152.6 ± 41.5 μg/l; Se-L: 146.7 ± 20 0 μg/l; C: 67.6 ± 13.1 μg/l). The highest concentration was found in the group supplemented with Se-yeast with a high content of selenomethionine. The other two organic forms of selenium (proteinate and lactate-protein complex) increased the concentration of Se in blood and the activity of GPx to the same extent as the inorganic form of selenium. Se supplementation did not have a negative effect on the concentration of copper and zinc in the blood serum of kids, but we found decreased concentrations of thyroxine in the experimental groups (Se-Y: 79.8 ± 12.8 nmol/l; Se-I: 66.5 ± 13.2 nmol/l; Se-P: 76.2 ± 25.7 nmol/l; Se-L: 84.5 ± 14.8 nmol/l; C: 92.7 ± 13.4 nmol/l). Significant differences were found between the group C and groups Se-I and Se-P (P < 0.05). The supplementation of mothers with Se both in organic and inorganic forms was sufficient to prevent Se deficiency in kids at the time of weaning.

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Section: Discussionsupporting

confidence: 91%

The effect of various forms of selenium supplied to pregnant goats on selected blood parameters and on the concentration of Se in urine and blood of kids at the time of weaning

Pechová¹,

Sevcikova²,

Pavlata³

et al. 2012

Vet. Med. - Czech

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“…The highest concentration of Se in the blood in group S is also because of the incorporation of selenomethionine into hemoglobin and albumin instead of methionine. Any selenomethionine that is not immediately metabolized is incorporated into organs with high rates of protein synthesis such as the skeletal muscles, erythrocytes, pancreas, liver, kidney, stomach, and the gastrointestinal mucosa; the retention was similar to that observed with 35 S-methionine and 14 C-phenylalanine. This allows Se to be stored in the organism and reversibly released by normal metabolic processes, thus, offering an advantage over other Se compounds [12].…”

Section: Resultssupporting

confidence: 66%

“…We found no clinical symptoms of toxicity, and the blood examination showed no toxic effects of the administered selenium doses either. Like us, Hayashida et al [14] found concentration higher then 200 µg l −1 after administration of soluble glass Se bolus (130 µg per day) in Fig. 1 Selenium concentration in goat blood in individual groups (C control, S Se yeast, B Se proteinate, L Se lactate) at the beginning and at the end of monitored period.…”

Section: Resultsmentioning

confidence: 78%

Monitoring of Changes in Selenium Concentration in Goat Milk During Short-Term Supplementation of Various Forms of Selenium

Pechová

Mišurová

Pavlata

et al. 2007

Biol Trace Elem Res

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The goal of the experiment was to monitor the changes in the selenium concentration in goat milk during short-term oral supplementation of three different forms of selenium. The experiment involved 24 lactating goats of white shorthaired breed. Group C was the control; group S received selenium in the form of selenium-enriched yeast, group L in the form of lactate, and group B in the form of proteinate. Individual selenium preparations were administered individually orally in 250 microg Se dose per animal for 20 days. After the beginning of selenium supplementation, the selenium concentration in milk during the first 5 days grew gradually in group S. Between days 7 and 20 of Se supplementation, the mean Se concentrations in milk in groups were 12.53 +/- 3.69 microg l(-1) (C), 25.90 +/- 6.30 microg l(-1) (S), 13.14 +/- 3.54 microg l(-1) (L), 11.70 +/- 3.69 microg l(-1) (B). Differences between group S and other groups (C, B, L) were highly significant (p < 0.0001). Based on our results, selenium in the form of lactate and proteinate was excreted into the milk similarly, but selenium in the form of yeast, which contains high amount of selenomethionine, was excreted by milk in the highest amounts.

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“…The FEEDAP Panel reviewed those references; most of them were considered not suitable for this assessment since: (i) were performed in non‐ruminant species; (ii) the source of selenium was not sodium selenate; (iii) sodium selenate was not administered as a bolus; or (iv) no information was available on the source of selenium in the bolus. Only four papers could be considered partially relevant for this assessment (use of sodium selenate as a bolus in ruminant species): one was conducted in cattle (Sprinkle et al., ) and three in goat (Serra et al., ; Fujihara et al., ; Hayashida et al., – all from the same research group); however, none of them was a proper tolerance study, since the animals received an adequate dose of sodium selenate (together with other trace elements as cobalt and iodine) . All these studies were considered ‘field trials’ performed in ruminants fed on local pastures with the objective to provide a long‐term mineral supplementation to cover the physiological needs and improve productivity.…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of sodium selenate as feed additive for ruminants

Additives¹,

Bampidis²,

Azimonti³

et al. 2019

EFS2

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Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of sodium selenate as a nutritional feed additive for ruminants, when used via an intraruminal bolus in ruminants. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel concludes that based on (i) the estimation of the release of selenium from the bolus, (ii) the similarities in bioavailability with sodium selenite, (iii) the experience with the use of boluses in ruminant nutrition and (iv) the wide margin of safety compared with the maximum tolerable levels of selenium in ruminants, the additive is safe for ruminants. The use of sodium selenate by bolus administration providing a selenium intake not exceeding that resulting from the maximum authorised EU level of total selenium in feed presents no concerns for consumer safety. The additive does not pose a risk to users by inhalation and is considered as non-corrosive but irritant for the skin and the eyes. The FEEDAP Panel considers the additive as a skin sensitiser and respiratory sensitiser. The additive under assessment, in its intended use as complementary feed for ruminants in the form of boluses, is a substitute for other authorised selenium additives and will not further increase the environmental burden of selenium. Based on two studies submitted in cattle and sheep and studies from the literature, the FEEDAP Panel concludes that sodium selenate delivered by a bolus to ruminants is an efficacious source of selenium in meeting the animals' requirements. The Panel posed some recommendations regarding the use of the bolus, especially in small size ruminants. The Panel also posed a remark, concerning the zinc content of the bolus from which the additive is delivered.

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Effect of soluble glass bolus administration on the blood selenium concentration in grazing Philippine goats under backyard conditions

Cited by 3 publications

References 15 publications

The effect of various forms of selenium supplied to pregnant goats on selected blood parameters and on the concentration of Se in urine and blood of kids at the time of weaning

The effect of various forms of selenium supplied to pregnant goats on selected blood parameters and on the concentration of Se in urine and blood of kids at the time of weaning

Monitoring of Changes in Selenium Concentration in Goat Milk During Short-Term Supplementation of Various Forms of Selenium

Safety and efficacy of sodium selenate as feed additive for ruminants

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