Effect of Soluplus^® on γ-cyclodextrin solubilization of irbesartan and candesartan and their nanoaggregates formation

Supersaturated Drug Delivery System of Oxyberberine Based on Cyclodextrin Nanoaggregates: Preparation, Characterization, and in vivo Application

“…However, beyond enhancing drug solubility, CDs can also maintain supersaturated solutions of drugs as precipitation inhibitors, 33–35 which may be related to the self-assembly of cyclodextrin nanoaggregates. 36 Therefore, we hypothesized that the dual properties of CDs would facilitate the stable formulation of OBB-SDDS system with increased bioavailability. Based on the promising application of HP-β-CD for drug supersaturation, our work aimed to develop OBB-SDDS based on CDs to improve the solubility and bioavailability of OBB.…”