Effect of solvent coordination on the structure of β‐diketone‐based vanadyl complexes and assessment of in vitro antidiabetic activity and cytotoxicity

Abstract

The physicochemical properties, thereby the biological efficacy, of metal complexes are affected based on their structure and geometry that vary in the presence of coordinating and non-coordinating solvents. To investigate this, in the present work, we synthesized three hitherto unreported β-diketone-based oxovanadium(IV) complexes, namely [VO(tfdmh) 2 ] (tfdmh =1,1,1-trifluro-5,5dimethyl-2,4-hexanedione), [VO(dmh) 2 ] (dmh = 2,2-dimethyl-3,5-hexanedione) and [VO(dbm) 2 ] (dbm = 1,3-diphenylpropane-1,3-dione), and characterized them using electron paramagnetic resonance, UV-visible, Fourier transform infrared and electrospray ionization mass spectroscopies and single-crystal X-ray diffraction. The structural changes in the presence of dichloromethane, dimethylsulfoxide and dimethylformamide were analysed using spectroscopic techniques. Further, in vitro glucose uptake efficacy and cytotoxicity were assessed using C2C12 (rat skeletal muscle) and HeLa (human cervical cancer) cell lines, respectively.

Synthesis and structural characterization of oxovanadium(IV) complexes of dimedone derivatives

“…The cytotoxic activity, of VO (IV) complexes ( 1–3 ), is evaluated for in vitro anti‐tumor activity against two different human cell lines: (i) HepG‐2, and (ii) MCF‐7, by using vinblastine and colchicine as a reference compounds (referring to Figures 9 and 10). [ 47–49 ] Table 4 represents summary of the calculated values of the IC 50 by using Equation , for the tested VO (IV) complexes. These results revealed that the complex 1 (IC 50 = 115 ± 6.9, and 169 ± 8.7 μg/mL) is exhibiting non‐toxicity against the two cell lines HepG‐2 and MCF‐7, respectively, as compared to the Colchicine (IC 50 = 10.6 ± 0.…”