Effect of Solvent on Nanoparticle Production of <i>β</i>‐Carotene by a Supercritical Antisolvent Process

Nerome, Hazuki; Machmudah, Siti; Diono, Wahyu; Fukuzato, Ryuichi; Higashiura, Takuma; Kanda, Hideki; Goto, Motonobu

doi:10.1002/ceat.201500519

Cited by 12 publications

(7 citation statements)

References 45 publications

(57 reference statements)

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“…At these conditions, the increasing operating temperature leads to the decreasing CO2 density, thus the dissolving ability of CO2 also decreases. Then supersaturation will decrease and the bigger size of -carotene particles products will be formed [17,25,29,30]. Imsanguan et al [29] investigated the effect of operating temperature on the SCCO2 antisolvent to precipitate andrographolide.…”

Section: Resultsmentioning

confidence: 99%

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Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Kodama¹,

Honda²,

Machmudah³

et al. 2018

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The crystallization of -carotene through supercritical antisolvent process with carbon dioxide (CO2) as an antisolvent has been demonstrated. The experiments were conducted at temperatures of 40-60 o C and pressures of 10-14 MPa at a constant CO2 flow rate. As a starting material, -carotene powder was dissolved in dichloromethane (DCM). Results of UV-vis spectrophotometry and GC-MS analysis showed that there was no remaining DCM solvent in the -carotene particles products. It showed that CO2 has successfully removed DCM from -carotene particles products. The product characterization by using fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) showed that the CO2 solvent did not impregnate to the -carotene particles products. Results from scanning electron microscope (SEM) images showed that the -carotene particles products were successfully prepared in plate-like shape morphologies with size around 1 m.

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Section: Resultsmentioning

confidence: 99%

“…Carbon dioxide (CO2; 99%) was supplied by Sogo Kariya Sanso, Inc. Japan. This concentration was selected based on the previous report [17]. Fig.…”

Section: Materials and Chemicalsmentioning

confidence: 99%

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Kodama¹,

Honda²,

Machmudah³

et al. 2018

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“…Nerome, et al [ 112 ] prepared β-carotene NPs by SEDS method through pumping β-carotene (1.5 mg/mL) in different solvents (dichloromethane, n -hexane, ethyl acetate or N ,N-dimethylformamide) at a flow rate of 0.25 mL/min into a precipitator under different pressure (8–12 MPa) and temperature (40–60 °C) conditions. SCF-CO 2 was simultaneously pumped at 20 mL/min for mixing with β-carotene solution and extrusion through a coaxial nozzle ( Figure 13 A).…”

Section: Preparation Physicochemical Characterization Stability Evaluation and Biological Activitymentioning

confidence: 99%

“…In ( A ), steps 1 to 15 represent different processing steps involved in solution enhanced dispersion by supercritical fluid method. Adapted with permission from Kaga, et al [ 61 ] and Nerome, et al [ 112 ].…”

Section: Figurementioning

confidence: 99%

Recent Advances on Nanoparticle Based Strategies for Improving Carotenoid Stability and Biological Activity

2021

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Carotenoids are natural pigments widely used in food industries due to their health-promoting properties. However, the presence of long-chain conjugated double bonds are responsible for chemical instability, poor water solubility, low bioavailability and high susceptibility to oxidation. The application of a nanoencapsulation technique has thus become a vital means to enhance stability of carotenoids under physiological conditions due to their small particle size, high aqueous solubility and improved bioavailability. This review intends to overview the advances in preparation, characterization, biocompatibility and application of nanocarotenoids reported in research/review papers published in peer-reviewed journals over the last five years. More specifically, nanocarotenoids were prepared from both carotenoid extracts and standards by employing various preparation techniques to yield different nanostructures including nanoemulsions, nanoliposomes, polymeric/biopolymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid nanoparticles, supercritical fluid-based nanoparticles and metal/metal oxide nanoparticles. Stability studies involved evaluation of physical stability and/or chemical stability under different storage conditions and heating temperatures for varied lengths of time, while the release behavior and bioaccessibility were determined by various in vitro digestion and absorption models as well as bioavailability through elucidating pharmacokinetics in an animal model. Moreover, application of nanocarotenoids for various biological applications including antioxidant, anticancer, antibacterial, antiaging, cosmetics, diabetic wound healing and hepatic steatosis were summarized.

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“…Because of the advantages of carbon dioxide (CO 2 ), namely its nontoxicity, nonflammability, environmental friendliness, and mild supercritical conditions, CO 2 is recognized as a green solvent and is commonly used in the SAS process. In the literature, the SAS process has been demonstrated to be superior to the conventional crystallization process for the modification of the solid-state properties of pharmaceutical and biological compounds, such as baicalein, curcumin, palmitoylethanolamide, quercetin, β-carotene, ellagic acid, etoposide, indomethacin, mangiferin, rutin, tetracycline, aescin, carbamazepine, curcumin, gefitinib, levofloxacin, primidone, warfarin, and naringenin [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Using SAS, crystals with sizes in the range of microns to nanometers, regular crystal habit, and narrow size distribution can be produced.…”

Section: Introductionmentioning

confidence: 99%

Recrystallization and Production of Spherical Submicron Particles of Sulfasalazine Using a Supercritical Antisolvent Process

2018

Crystals

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Abstract:In this study, the recrystallization and production of spherical submicron particles of sulfasalazine, an active pharmaceutical ingredient (API), were performed using the supercritical antisolvent (SAS) process, a nonconventional crystallization technique. Sulfasalazine was dissolved in tetrahydrofuran (THF), and supercritical carbon dioxide (CO 2 ) served as the antisolvent. The effects of operating parameters on the SAS process, including the operating pressure, solution concentration, solution flowrate, CO 2 flowrate, and spraying nozzle diameter, at two operating temperatures were examined. The solid-state characteristics of sulfasalazine before and after the SAS process, including particle size, crystal habit, and crystal form, were analyzed using a scanning electron microscope (SEM), powder X-ray diffractometer (PXRD), and differential scanning calorimeter (DSC). A higher operating temperature, intermediate operating pressure, higher CO 2 flowrate, and lower solution flowrate are recommended to obtain spherical particles of sulfasalazine. The effects of the solution concentration and spraying nozzle diameter on the SAS process were negligible. Under optimal conditions, spherical sulfasalazine crystals with a mean size of 0.91 µm were generated, and this study demonstrated the feasibility for tuning the solid-state characteristics of API through the SAS process.

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Effect of Solvent on Nanoparticle Production of β‐Carotene by a Supercritical Antisolvent Process

Cited by 12 publications

References 45 publications

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Recent Advances on Nanoparticle Based Strategies for Improving Carotenoid Stability and Biological Activity

Recrystallization and Production of Spherical Submicron Particles of Sulfasalazine Using a Supercritical Antisolvent Process

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