Effect of Somatostatin on Pentagastrin Stimulated Secretion by Isolated Canine Stomachs, Perfused &lt;i&gt;ex vivo&lt;/i&gt; with Homologous Blood

Kowalewski, K.; Kolodej, A.; Kocylowski, M

doi:10.1159/000198148

Digestion

1978

DOI: 10.1159/000198148

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Effect of Somatostatin on Pentagastrin Stimulated Secretion by Isolated Canine Stomachs, Perfused <i>ex vivo</i> with Homologous Blood

K. Kowalewski¹,

A. Kolodej²,

M Kocylowski³

Abstract: The effect of somatostatin on pentagastrin-induced gastric secretion was assessed on 6 isolated canine stomachs perfused ex vivo with homologous blood. Hormones were given at a constant rate into the gastric arterial circulation. Somatostatin caused inhibition of the HCl concentration and output and reduced the secretion volume in all stomachs studied. The output but not the concentration of pepsin was also reduced.

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1985

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Effect of Somatostatin on Pentagastrin-Stimulated Gastric Acid Secretion and Gastric Antral Motility in Dogs with Gastric Fistula

Bech

Andersen

1984

Scandinavian Journal of Gastroenterology

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The purpose of the present study was to evaluate the effect of somatostatin on gastric acid secretion and gastric antral motility in conscious dogs with gastric fistula. Infusion of pentagastrin induced motility with a digestive pattern. Somatostatin inhibited dose-dependently the stimulated acid secretion, whereas the effect on antral motility was more complex, acting especially on the amplitude of the contractions. The effects of somatostatin were not altered by using alpha- and beta-adrenergic, dopaminergic, and serotonergic blocking drugs. The dose-response kinetics with seven doses of pentagastrin with and without somatostatin showed inhibition of a competitive type for gastric acid secretion and of a non-competitive type for antral motility with regard to amplitude.

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Effect of Somatostatin on Pentagastrin-Stimulated Gastric Acid Secretion and Gastric Antral Motility in Dogs with Gastric Fistula

Bech

Andersen

1984

Scandinavian Journal of Gastroenterology

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Effect of Somatostatin on Bethanechol-Stimulated Gastric Pepsin Secretion in Gastric Fistula Dogs

Ladegaard¹,

Bech²,

Andersen³

1985

Scandinavian Journal of Gastroenterology

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The effect of somatostatin on pepsin secretion was determined in six dogs with gastric fistulas during stimulation with bethanechol. Somatostatin inhibited dose-dependently the stimulated pepsin secretion, with a dose of 0.3 micrograms/kg/h being 35% inhibitory during stimulation with bethanechol, 80 micrograms/kg/h. Continuous infusion of somatostatin for 3 h did not cause any signs of tachyphylaxis. Withdrawal of somatostatin produced a return to the control level. The dose-response kinetics with five doses of bethanechol with and without somatostatin showed inhibition of a noncompetitive type. The effects of somatostatin were not altered by using adrenergic, dopaminergic, or serotonergic blocking drugs.

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Effect of Somatostatin on Pentagastrin Stimulated Secretion by Isolated Canine Stomachs, Perfused <i>ex vivo</i> with Homologous Blood

Cited by 2 publications

References 0 publications

Effect of Somatostatin on Pentagastrin-Stimulated Gastric Acid Secretion and Gastric Antral Motility in Dogs with Gastric Fistula

Effect of Somatostatin on Pentagastrin-Stimulated Gastric Acid Secretion and Gastric Antral Motility in Dogs with Gastric Fistula

Effect of Somatostatin on Bethanechol-Stimulated Gastric Pepsin Secretion in Gastric Fistula Dogs

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