Effect of Some Kindof Vegetable Oils on Hypercholesterolemic Rats

Abstract

The present study was carried out to investigate the effect of using some vegetable oils as (garlic oil, flaxseed oil, sesame oil, fenugreek oil, Nigella oil, soybean oil, cumin oil, onion oil and their oil blend) at ratio 15% level on daily food intake , body weight gain , feed efficiency ratio ,also on serum glucose level , serum blood lipids fraction, liver and kidney function on hypercholesterolemic rats. A total of (66) male albino rats 120±5g body weight used in this study. Rats were divided into two main groups , the first group (A) 6 rats was used as a control negative group (-ve) and fed on the basal diet only , the second group (60 rats) fed on the hypercholesterolemic diet (1.5% cholesterol +0.25% bile salts) for two week to induce hypercholesterolemia and then divided randomly into (10 subgroups) one of them used as a control positive (+ve) fed on hypercholesterolemic diet only (group B).The other subgroups fed on hypercholesterolemic diet containing 15% of each of vegetable oils as substituent to corn oil.A blend of all oils at equal amounts was also used. The results revealed that the feeding of hypercholesterolemic rats on all kinds of different oil increased significant of weight gain, food intake and FER as compared to (+ve) group. It showed significant reduction of serum total cholesterol, triglycerides, and serum glucose level compared to the control positive group (B).All experimental diet increased serum concentration of HDL-c, decreased concentration of serum AST, ALT enzymes, uric acid, urea nitrogen and creatinine of hypercholesterolemic rats. This study revealed that the best result obtained with garlic oil for all parameters; this treatment showed nonsignificant change compared with control negative (A) group.