Effect of some Plants and Pesticides on Acetylcholinesterase

Khorshid, M. A.; Hassan, Fatma A.M.; El-Gawad, A.M. Mona Abd; Enab, A.K.

doi:10.3923/ajft.2015.93.99

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…Regarding its mechanism of action, coumaran may also be compared to the monoterpene 1,8-cineole [ 31 ] or other synthetic pesticides such as organophosphates and carbamates [ 32 ]. Moreover, Khorshid, et al [ 33 ] have presented the inhibitory activity of methanolic extract from Cassia fistula L. (Fabaceae) roots and proposed the indole alkaloids as new potential active agents. However, it should be noted that many essential oils and terpenes therefrom have demonstrated anti-AChE activity in vitro, but their contribution to insect mortality is questionable [ 34 ].…”

Section: Plant Derived Insecticides That Affect the Nervous Systemmentioning

confidence: 99%

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

Sylvestre²,

et al. 2021

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Pests and diseases are responsible for most of the losses related to agricultural crops, either in the field or in storage. Moreover, due to indiscriminate use of synthetic pesticides over the years, several issues have come along, such as pest resistance and contamination of important planet sources, such as water, air and soil. Therefore, in order to improve efficiency of crop production and reduce food crisis in a sustainable manner, while preserving consumer’s health, plant-derived pesticides may be a green alternative to synthetic ones. They are cheap, biodegradable, ecofriendly and act by several mechanisms of action in a more specific way, suggesting that they are less of a hazard to humans and the environment. Natural plant products with bioactivity toward insects include several classes of molecules, for example: terpenes, flavonoids, alkaloids, polyphenols, cyanogenic glucosides, quinones, amides, aldehydes, thiophenes, amino acids, saccharides and polyketides (which is not an exhaustive list of insecticidal substances). In general, those compounds have important ecological activities in nature, such as: antifeedant, attractant, nematicide, fungicide, repellent, insecticide, insect growth regulator and allelopathic agents, acting as a promising source for novel pest control agents or biopesticides. However, several factors appear to limit their commercialization. In this critical review, a compilation of plant-derived metabolites, along with their corresponding toxicology and mechanisms of action, will be approached, as well as the different strategies developed in order to meet the required commercial standards through more efficient methods.

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Section: Plant Derived Insecticides That Affect the Nervous Systemmentioning

confidence: 99%

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

Sylvestre²,

et al. 2021

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“…Recent researches showed that AChE inhibitors not only alleviate the cognitive defect of AD patients by elevating acetylcholine (ACh) levels, but also act as disease modifying agents by preventing the early step of AD, the assembly of β -amyloid peptide (Aβ) into amyloid plaque 23 , 24 . Nevertheless, some obvious adverse effects including nausea and vomiting, decreased appetite, weight loss, hepatotoxicity or problems associated with bioavailability were also reported for these drugs 25 – 28 . Additionally, these drugs are only focused on the symptomatic aspects but cannot prevent, halt or reverse the progression of the disease 14 .…”

Section: Introductionmentioning

confidence: 99%

New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship

Zhou

Zhang

et al. 2018

Sci Rep

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A series of 2-aryl-9-methyl-β-carbolinium bromides (B) were synthesized and explored for anti-acetylcholinesterase (AChE) activities in vitro, action mechanism and structure-activity relationship. All the compounds B along with their respective 3,4-dihydro intermediates (A) presented anti-AChE activity at 10 μM. Thirteen compounds B showed the excellent activity with IC50 values of 0.11–0.76 μM and high selectivity toward AChE relative to butyrylcholinesterase (BChE), superior to galantamine (IC50 = 0.79 μM), a selective AChE inhibitor drug. Kinetic analysis showed that the action mechanisms of both compounds B and A are a competitive inhibition model. Structure-activity relationship analyses showed that the C = N+ moiety is a determinant for the activity. Substituents at 6, 7 or 4′ site, the indole-N-alkyl and the aromatization of the C-ring can significantly improve the activity. Molecular docking studies showed that the compounds could combine with the active site of AChE by the π-π or cation-π action between the carboline ring and the phenyl rings of the residues, and the β-carboline moiety is embedded in a cavity surrounded by four aromatic residues of Trp86, Tyr337, Trp439 and Tyr449. The present results strongly suggest that the para-position of the D-ring should be a preferred modification site for further structural optimization design. Thus, 2-aryl-9-methyl-β-carboliniums emerged as novel and promising tool compounds for the development of new AChE inhibitor agents.

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“…[70] Thus, R. serpentina was an effective candidate as a source of antioxidants and AChE inhibitors. [74] In another study by Saharia et al, reserpine efficacy in the treatment of AD was evaluated. [75] They reported that AChE is responsible for increasing the reserpine mediated lifespan [76] and reduction in Aβ toxicity.…”

Section: R Serpentina and Neurodegenerative Diseases (Ndd)mentioning

confidence: 99%

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Singh

2017

IJGP

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Rauwolfia serpentina is reported in an Ayurvedic medicinal system for centuries, for the treatment of various ailments such as snakebites, insomnia, hypertension, and insanity. Scientific evaluation of these documents can be valuable for finding new potential use in neurological disorders. The work presents the brief overview of R. serpentina including a description of the plant, its active chemical constituents and pharmacological properties with the major emphasis on cardiovascular and central nervous system disorders. This review compiles information available in the scientific literature from databases such as Science Direct, PubMed, India bioscience. org, Herbs -Medicinal plant usage and Identification Database, Database on medicinal plants used in Ayurveda and Siddha, Missouri Botanical Garden, National Medicinal Plants Board, and the International Plant Names Index. Information gathered from the literature has shown that the alkaloids are the major constituents of the plant imparting various pharmacological properties. Reserpine, the Indole alkaloid, is the most active compound of R. serpentine. The plant is known to possess antidiarrheal, antimicrobial activity apart from using it for the treatment of circulatory disorders, rheumatism, hypertension, insanity, epilepsy, and leaves are used in the removal of opacities of the cornea. Research shows that R. serpentine is a potential source of compounds pertaining medicinal applications. It provides an interesting subject in the search for new drugs of natural origin.

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Effect of some Plants and Pesticides on Acetylcholinesterase

Cited by 6 publications

References 17 publications

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges

New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship

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