Effect of Sotalol Against Reperfusion‐induced Arrhythmias in Sprague‐dawley and Wistar Rats

Lamontagne, Daniel; Rochette, Luc; Vermeulen, Michel; Yamaguchi, Nobuharu; Nadeau, Réginald; Champlain, Jacques de

doi:10.1111/j.1472-8206.1989.tb00468.x

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…8,11,12 Only a modest amount of research has been conducted on class III compounds, blocking outward K + currents, perhaps due to the fact that rats lack the delayed rectifier K + currents. Melperone, 157 bethanidine, meobentine, 158 sotalol, 159 and tedisamil 160 all protected against arrhythmias; however, except for tedisamil, none of these drugs are selective class III agents but also possess ancillary properties which could contribute to their antiarrhythmic effect. The antiarrhythmic effect of tedisamil can instead be ascribed to blockade of I to , a K + current appearing early in both the rat and human ventricular AP.…”

Section: Interventions Applied To Rat Models Of Vf Caused By Amimentioning

confidence: 99%

Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

Hundahl

Tfelt-Hansen

Jespersen

2017

J Cardiovasc Pharmacol Ther

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A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.

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Section: Interventions Applied To Rat Models Of Vf Caused By Amimentioning

confidence: 99%

Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

Hundahl

Tfelt-Hansen

Jespersen

2017

J Cardiovasc Pharmacol Ther

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Antiarrhythmic properties of triamterene derivatives in the coronary artery ligated rat model

Büsch

Ullrich

Mutschler

1991

Archiv der Pharmazie

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Triamterene and several triamterene derivatives were tested for antiarrhythmic activity in the coronary artery ligated and reperfused (CAL-R) rat. The class-III antiarrhythmic drugs (+/-)-sotalol and amiodarone, the class-I antiarrhythmics lidocaine and quinidine as well as the potassium sparing diuretic amiloride were used as reference drugs. Triamterene at the highest dose (30 mumol/kg) revealed a 100% protection against ventricular fibrillation (VF), whereas at 10 mumol/kg no antiarrhythmic activity for triamterene could be found. For compound 4 (10 mumol/kg) a 75% protection against VF could be demonstrated, while 2, 3, and 5 revealed only a 25% protection. Compared to the reference drugs, triamterene and the derivatives 2-5 are more potent than (+/-)-sotalol, but less potent than lidocaine, quinidine and amiodarone. For amiloride as well as for the potent potassium retaining triamterene derivative 6 no antiarrhythmic activity could be shown. Therefore, we conclude different mechanisms responsible for the potassium sparing and antiarrhythmic properties of triamterene and its derivatives.

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Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo

Bril¹,

Landais²,

Gout³

1993

Cardiovasc Drug Ther

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The effects of the Ito blocker, tedisamil (0.1, 1.0, and 3.0 mg/kg, IV), and the IK blocker, E-4031 (0.1, 1.0, and 3.0 mg/kg, IV), on the incidence and duration of reperfusion-induced arrhythmias were compared in the anesthetized rat (n = 12 per group). Reperfusion arrhythmias were evaluated after a 5 minute occlusion period of the left main coronary artery. In the absence of any pronounced effect on blood pressure, tedisamil and E-4031 reduced heart rate in a dose-dependent manner. During the preischemic period, QTc interval was increased by tedisamil but was not changed by E-4031. Both compounds increased the QTc interval during the ischemic period and also during the reperfusion. E-4031 was unable to reduce the incidence and duration of reperfusion-induced ventricular arrhythmias after 5 minutes of coronary artery occlusion. Tedisamil dose-dependently reduced the duration of reperfusion arrhythmias and their incidence. In a second set of experiments, the combination of tedisamil (1.0 mg/kg) with E-4031 (1.0 mg/kg) was administered. The electrocardiographic action of this combination was similar to that observed with tedisamil given alone. However, with the combination the incidence of fibrillation was reduced from 83% in the control group to 8% in the treated group (p < 0.001), and the mortality was reduced from 67% to 0% (p < 0.001), that is, to a greater extent than with tedisamil (1.0 mg/kg) alone. The results show that the blockade of Ito by tedisamil allows a reduction of reperfusion-induced mortality and that a specific IK blocker (E-4031) is devoid of antifibrillatory action in the anesthetized rat.(ABSTRACT TRUNCATED AT 250 WORDS)

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Effect of Sotalol Against Reperfusion‐induced Arrhythmias in Sprague‐dawley and Wistar Rats

Cited by 7 publications

References 22 publications

Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

Antiarrhythmic properties of triamterene derivatives in the coronary artery ligated rat model

Actions and interactions of E-4031 and tedisamil on reperfusion-induced arrhythmias and QT interval in rat in vivo

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