Effect of sow and piglet porcine circovirus type 2 (PCV2) vaccination on piglet mortality, viraemia, antibody titre and production parameters

A commercial PCV2a-based vaccine significantly reduces PCV2b transmission in experimental conditions

“…Beside PCV2-SD, the involvement of the virus in subclinical infections and other syndromes such as Porcine Respiratory Disease complex, reproductive disorders or enteric diseases has been more and more documented [18]. The efficacy of PCV2 vaccination towards such PCV2 subclinical infections has also been shown through the improvement of growth performances and reduction of clinical and lesional consequences [19,20]. A meta-analysis based on 66 field trials showed that among the 4 commercial vaccines available on the market, no significant differences in efficacy (based on productivity measurement and mortality rates) could be found [21].…”

Immune Responses of Piglets Immunized by a Recombinant Plasmid Containing Porcine Circovirus Type 2 and Porcine Interleukin-18 Genes

“…Immunization against PCV2 has been studied intensely and found to be the most effective strategy for protecting pigs to date (11,13,21). However, the current vaccines do have some disadvantages.…”

Development of an indirect ELISA assay for the detection of IgG antibodies against the ORF1 of Torque teno sus viruses 1 and 2 in conventional pigs

“…This result should not be considered surprising since the inhibitory effect of MDA on the development of the humoral immune response upon infection has been well documented for other swine pathogens, as is the case of Erysipelothrix rhusiopathiae, H1N1 influenza virus or even in case of other ssDNA virus like PCV2. In these examples, development of the host immune response following vaccination or experimental infection was significantly influenced by the MDA status of the piglet at the time of vaccination or infection (Fraile et al, 2012;Loeffen et al, 2003).…”

“…Porcine sera used for detecting IgG antibodies against ORF1-A from TTSuV1 or TTSuV2 come from conventional healthy pigs (n = 37) and their dams (n = 15), selected from a larger PCV2 vaccination study (Fraile et al, 2012). All piglets were clinically monitored from weaning (4 weeks of age) until slaughter; blood samples were taken at 4, 8, 12, 16, 21 and 25 weeks of age.…”