Effect of soy protein-rich diet on renal function in young adults with insulin-dependent diabetes mellitus

Stephenson, Tammy; Setchell, Kenneth D.R.; Kendall, Cyril W.C.; Jenkins, David; Anderson, James W.; Fanti, Paolo

doi:10.5414/cnp64001

Cited by 48 publications

(44 citation statements)

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“…An absence of the association between the intake level of total protein and eGFR in 2419 postmenopausal women has been reported [34], and our observation was consistent to this observation. Several single meal studies reported an association of an increase in GFR with the animal source of protein, but not with the vegetable source, such as soy protein [10, 12] or an alleviation of RHF after a soy protein-rich diet [11]. The differential response of kidney to the sources of habitual protein intake observed in our study was consistent with these single meal studies.…”

Section: Discussionsupporting

confidence: 90%

The Association between Renal Hyperfiltration and the Sources of Habitual Protein Intake and Dietary Acid Load in a General Population with Preserved Renal Function: The KoGES Study

Song

Lee

et al. 2016

PLoS ONE

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Although the differential response of the kidney to the acute load of various sources of dietary protein in subjects with normal renal function is well known, the influence of habitual dietary protein intake and dietary acid load on renal function has not been tested well. The association between renal hyperfiltration (RHF), the earlier and possibly reversible stage of chronic kidney disease, and the sources of habitual dietary protein and dietary acid load was analyzed with the baseline data of 123,169 middle-aged healthy Koreans of a large prospective cohort study, who had a baseline estimated glomerular filtration rate (eGFR) >60 mL/min/m2 and no known history of diabetes and/or hypertension. eGFR was calculated with the Chronic Kidney Disease Epidemiology Collaboration equation using serum creatinine and RHF was defined as eGFR >95th percentile after adjustment for age, sex, height, and body weight. Dietary acid load was calculated with estimated net endogenous acid production (eNEAP). Although the level of habitual intake of animal protein was positively and vegetable protein was negatively associated with RHF, this association was significant only in women and younger participants (younger than sex-specific median age). The odds for RHF increased as the percentile rank of eNEAP increased until about the 50th percentile and then leveled off. The positive association between eNEAP and RHF was significant in both sexes and age groups. Dietary acid load was associated with RHF regardless of sex and age and rather than the amount of the total or the individual sources of habitual dietary protein, may be a better target for the dietary intervention of chronic kidney disease.

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Section: Discussionsupporting

confidence: 90%

The Association between Renal Hyperfiltration and the Sources of Habitual Protein Intake and Dietary Acid Load in a General Population with Preserved Renal Function: The KoGES Study

Song

Lee

et al. 2016

PLoS ONE

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“…A reduction in urinary protein and albumin excretion with soya protein intake has also been reported in both animal models and human subjects with nephropathy (Teixeira et al 2003(Teixeira et al , 2004Stephenson et al 2005). It is possible that the effect of soya protein on proteinuria that we observed is due to differences in protein reabsorption secondary to differences in the rate of progression of cyst formation on account of the perinatal interventions.…”

Section: Discussionsupporting

confidence: 67%

Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring

et al. 2007

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Dietary soya protein substitution for casein initiated at weaning slows disease progression in animal models of chronic renal disease. As there is increasing evidence that fetal programming can have a significant impact on kidney physiology and function in offspring, the objective of the current study was to determine whether exposure to soya protein in the diet earlier than weaning would have further benefits. Han:SPRD-cy (cy/þ ) breeder rats were fed a casein-based or soya protein-based diet 2 weeks prior to mating, throughout pregnancy and during lactation. Following this maternal period, 3-week-old pups were given either the same or the alternate diet for a 7-week weaning period. Dietary soya protein compared with casein in the maternal or weaning period both independently resulted in less renal inflammation (macrophage infiltration lower by 24 % (P¼ 0·0003) and 32 % (P, 0·0001), respectively). When soya protein was given in both feeding periods, the effect was additive. Soya protein substitution for casein resulted in less oxidative damage as indicated by 28 % lower oxidized-LDL staining (P¼ 0·013) when present in the maternal period, or in the weaning period (by 56 %, P,0·0001). Renal cell proliferation was reduced by 29-33 % (P,0·05) in rats given soya protein whether the exposure was during the maternal or weaning period. Soya protein compared with casein in the maternal period also resulted in 33 % (P¼ 0·0013) less proteinuria, indicating superior renal function. Dietary soya protein during pregnancy and lactation represents a potential preventative approach in treating for those with congenital kidney diseases.

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“…Soy protein has beneficial effects on renal function in diabetic and nondiabetic patients with nephropathy, reducing the glomerular filtration rate and improving creatinine clearance [95][96][97][98].…”

Section: Effect Of Soy Protein On Renal Functionmentioning

confidence: 99%

Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders

Torres

Torre-Villalvazo

Tovar

2006

The Journal of Nutritional Biochemistry

207

137

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Effect of soy protein-rich diet on renal function in young adults with insulin-dependent diabetes mellitus

Cited by 48 publications

References 0 publications

The Association between Renal Hyperfiltration and the Sources of Habitual Protein Intake and Dietary Acid Load in a General Population with Preserved Renal Function: The KoGES Study

The Association between Renal Hyperfiltration and the Sources of Habitual Protein Intake and Dietary Acid Load in a General Population with Preserved Renal Function: The KoGES Study

Dietary soya protein during pregnancy and lactation in rats with hereditary kidney disease attenuates disease progression in offspring

Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders

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