Effect of Soyasaponin on Pulmonary Tissue Apoptosis of Silicotic Fibrosis Rats

Xu, Hong‐Xi; Yu, Shi; Li, Qingzhao; Wu, Jing; Hao, Yulan; Fan, Hongmin; Wang, Manman; Liu, Nan; Zheng, Gen

doi:10.1007/978-1-4471-4802-9_97

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Journal Of Agricultural and Food Chemistry1

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2014

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“…58 The treatment of rats with silicotic pulmonary fibrosis with soyasaponins decreased the serum NO and reactive oxygen species (ROS) contents as well as the MDA level in pulmonary tissue, increased the serum SOD level, and inhibited the expression of Fas and FasL and the apoptosis of lung cells, which thus retarded the progress of SiO 2 -induced pulmonary fibrosis. 59,60 Soyasaponins bearing sugar chain(s) showed strong adjuvant activities and stimulated anti-chicken ovalbumin total-IgG and IgG1 antibody responses in mice. 61 Among the bisdesmosidic soyasaponins, soyasaponin A 1 , with a long sugar side chain, induced stronger total IgG and IgG1 antibody responses than did soyasaponin A 2 .…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Biological Functionality of Soyasaponins and Soyasapogenols

Guang

Chen

Sang

et al. 2014

J. Agric. Food Chem.

109

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Soyasaponins are a group of structurally complex oleanane triterpenoids primarily found in soybeans and have diverse biological properties. The recent investigations and findings (since 2000) regarding the biological functions of soyasaponins and their aglycones, including their anti-inflammatory, antimutagenic, anticarcinogenic, antimicrobial, and hepato- and cardiovascular-protective activities, are herein summarized. The primary conclusion is that the use of soyasaponins and soyasapogenols in functional foods should be considered.

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