Effect of Soybean on Bone Health and Some Metabolic Parameters in Postmenopausal Egyptian Women

Abstract

Introduction: Great concern has been raised recently concerning the therapeutic impact of soybean. The present study aims to investigate the effects of soybean on bone health and metabolic parameters in postmenopausal women. Methods: In this clinical study, 72 healthy postmenopausal women aged between 45-65 years were given soybean bioactive fraction 2 capsules (500mg each) daily for 24 weeks. Each capsule contained 31.25 mg proteins, 3.2 mg carbohydrates and 4.84 mg isoflavones. Blood pressure, bone mineral density, plasma osteocalcin (OCN), telopeptides of collagen type I (CTX), fasting insulin and blood glucose, lipid profile, serum creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and TSH were assessed prior and after the period of the study. Insulin resistance was calculated by homeostatic model assessment-IR formula (HOMA-IR). Results: Soy ingestion resulted in a significant increase in T score of the hip and OCN; recording -1.97±0.13/-1.76±0.12 and 22.44±0.60ng/ml/30.93±0.57ng/ml before/after treatment, respectively. A marked decrease was also detected in CTX from 2.22±0.10ng/ml to 1.48±0.08ng/ml. With regard to metabolic parameters, there was a significant decrease in fasting insulin (5.40±0.62uU/ml vs 4.15±0.45uU/ ml), however, fasting glucose and HOMA-IR showed no significant alterations. Lipid profile displayed remarkable decline in total cholesterol (188.86±7.23mg/dl vs 159.60±4.72mg/dl, triglycerides (97.09±5.23mg/dl vs 83.56±4.27mg/dl), LDL-c (75.60±3.06mg/dl vs 63.95±1.86mg/ dl) accompanied with a significant elevation in HDL-c (53.09±0.88 vs 65.81mg/dl±0.80mg/ dl). A significant decrease in both TSH (1.97±0.13 uIU/ml vs 1.40±0.08 uIU/ml) and serum creatinine (0.82±0.02mg/dl vs0.77±0.02mg/dl) was also noticed. Conclusion: Consumption of soy improves bone health, reduces cardiovascular risk with no adverse effects on kidney, liver or thyroid functions.

Metabolomic study of the estrogenic and anti‐osteoporotic potential of Erythrina bidwillii leaf

“…Menopause has significant detrimental side effects on women’s health, such as urogenital atrophy and osteoporosis.Many women pursue the administration of PEs as safer and efficient HRT to compensate for the decline in innate estradiol levels (AbouZeid et al, 2022; Rietjens et al, 2017; Salam et al, 2021). Traditionally, various Erythrina spp.…”

“…These symptoms are usually treated with conventional hormone replacement therapy (HRT), which has severe adverse effects such as a higher risk of blood clotting and breast, ovarian and endometrial cancer. Women all over the world use phytoestrogens (PEs) as complementary therapy to treat these undesirable symptoms (AbouZeid et al, 2022; Rietjens et al, 2017; Salam et al, 2021).…”