Effect of space flight factors simulated in ground-based experiments on the behavior, discriminant learning, and exchange of monoamines in different brain structures of rats

Biological Protection in Deep Space Missions

“…The consistency of our previous work [24,25] and others [26,27] was noted by Cortese et al who published this report. There is a strong evidence of a wide range of adaptive responses among different individuals, suggesting that medical selection of the astronaut candidates based on in vitro screening of the adaptive responses might decrease the radiation induced health risks in deep space [25][26][27]. A key factor is the effect of the space radiation on the organism's integrated protection systems (e.g., DNA repair and immune system response) against biomolecular damage induced by ionizing radiation.…”

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

“…There are a lot of disparate data about the detrimental effects of the SFC onto the cognitive abilities, and on the mechanisms underlying neurodegenerative disorders [ 106 , 107 ]. To date, the neurochemical and molecular mechanisms underlying the cognitive impairments resulting from the effects of SFC are not clearly understood; even information about the potential risks for the CNS is contradictory [ 108 , 109 ].…”

“…Nevertheless, according to current regulations, the results of such studies are not necessarily taken into consideration along the process of candidates selection for the spaceflight. There is a strong evidence of a wide range of adaptive response among different individuals, suggesting that medical selection of the candidates based on the in vitro adaptive response studies is very promising [ 108 , 186 , 188 , 189 ]. The wide spectrum of responses may be explained by various rates of DNA damage accumulation and repair [ 190 – 194 ].…”

Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight

“…Moreover, the ground-based models used in researches simulated mostly only one or two of the environmental factors, such as microgravity (Seaton et al, 2009), isolation and confinement (Basner et al, 2014), or noise (Cheng et al, 2011), which differ greatly from the real spaceflight environment. To the best of our knowledge, only a few attempts have been made to study the influence of a simulated complex spaceflight environment on cognitive function (Ma et al, 2013; Shtemberg et al, 2014), and no comprehensive studies involving complex factors have yet been performed. Simulating spaceflight environment including complex factors are important for systematic study of the effects on cognition.…”