Effect of Specific Retinoic Acid Receptor Agonists on Noise-Induced Hearing Loss

Kwak, Sang Hyun; Nam, Gi‐Sung; Bae, Seong Hoon; Jung, Jinsei

doi:10.3390/ijerph16183428

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…18 Kwak et al veri ed the differences among selective agonists of retinoic acid receptors (RARs) in NIHL, in which selective agonists of RAR demonstrate comparable protective effects against NIHL to retinoic acid. 19 Although the direct association between Niacin and NIHL has not yet been studied, previous studies have reported the association between Niacin and age-related hearing loss (ARHL). In a rat model of stroke, niacin treatment signi cantly increased not only brain-derived neurotrophic factor (BDNF), but also synaptic plasticity and axonal growth.…”

Section: Discussionmentioning

confidence: 99%

Association of Dietary Factors with Noise Induced Hearing Loss in Korean Population: A 3-Year National Cohort Study

Lee

Yoon

et al. 2021

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Noise-induced hearing loss (NIHL) is a hearing impairment caused by various epidemiologic and clinical factors. Identifying the relationship between NIHL and nutrients could help reduce the prevalence of hearing loss. This study analyzed the relationship between NIHL and dietary factors using data of the Korea National Health and Nutrition Examination survey. The survey was taken by a total of 10,850 participants aged 20-65 years. Air conduction audiometry was measured at 500, 1000, 2000, and 4000Hz in both ears. Metabolic syndrome, noise exposure, drink, smoke, income, marital status, and nutritional intake were evaluated. The differences between non-HI and HI participants in noise-exposed group have shown statistically significant differences in age, sex, marital status, smoking status, alcohol consumption, fast glucose level, and triglyceride level (p<0.05). In a multiple regression analysis, the age factor showed a significant association with HI (OR: 0.604; 95% CI: 0.538-0.678). In multivariate analysis for dietary factors, Retinol (OR: 1.356; 95% CI: 1.068-1.722), Niacin (OR: 1.5; 95% CI: 1.022-2.201) and Carbohydrates (OR: 0.692; 95% CI: 0.486-0.985) showed a significant association with NIHL. When the dietary factors of the noise exposure group were analyzed, high intake of Niacin and Retinol and low intake of Carbohydrates appear to prevent hearing loss.

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Section: Discussionmentioning

confidence: 99%

Association of Dietary Factors with Noise Induced Hearing Loss in Korean Population: A 3-Year National Cohort Study

Lee

Yoon

et al. 2021

Preprint

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“…3 School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China. 4 School of Public Health, Nantong University, Nantong, Jiangsu, China. Comparison of high-frequency hearing threshold shift of rs1053005 and rs1053023 genotypes in all subjects.…”

Section: Consent For Publicationmentioning

confidence: 99%

Association of STAT3 Gene polymorphism with noise-induced hearing loss(NIHL) in the Chinese population

Gao

Wang

D³

et al. 2020

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Objectives: NIHL is a disease with irreversible damage caused by multi-factor interaction, and the STAT3 is an essential protein with signal transduction and transcription functions. This study is aimed to explore the effect of STAT3 polymorphism on individual susceptibility to NIHL individuals, and to further examine the interaction between lifestyles and NIHL in the dominant model .Methods: This study was designed a case-control study and included 609 NIHL cases and 611 healthy hearing controls from the Jiangsu province of China. By collecting the lifestyle and demographic information of the study participants, genotyping the collected blood samples, and performing Real-time Quantitative PCR (qRT-PCR) to analyze and investigate the potential association between STAT3 SNPs and NIHL.Results: Statistical analysis results show that individuals carrying the C allele of rs1053023 and rs1053005 were more likely to develop NIHL than individuals carrying the T allele (OR = 1.367, 95% CI = 1.148-1.628, P = 0.0001 and OR = 1.37, 95% CI = 1.147-1.636, P = 0.001). In the dominant model (TC/CC genotype and TT genotype), stratified analysis of lifestyle, we found that people who smoke regularly are more likely to suffer from NIHL than non-smokers or occasional smokers. Besides, the expression of STAT3 was higher in NIHL cases by real-time quantitative PCR.Conclusion: Gene polymorphisms, rs1053023 and rs1053005, from STAT3, are associated with NIHL and C alleles of rs1053023 and rs1053005 within STAT3 may become biomarkers for workers exposed to noise.

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“…The authors declare that they have no competing interests. 4 , E-mail :zsh1994420@163.com; Baoli Zhu 1,2# ,E-mail:zhubaoli1965@126.com. 1 School of Public Health, Southeast University, Nanjing, Jiangsu Province, China.…”

Section: Availability Of Data and Materialsmentioning

confidence: 99%

“…3 School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China. 4 School of Public Health,Nantong University, Nantong, Jiangsu, China. * These authors contributed equally to this article…”

Section: Availability Of Data and Materialsmentioning

confidence: 99%

“…Current studies have found that this hearing impairment manifested cochlear hair cell synaptic damage and hair cell apoptosis have irreversible properties ,but its occurrence can be reduced by effective protection [3]. In industrial countries, noise is the most important cause of hearing loss compared with other risk factors for hearing loss [4]. Also, NIHL has been a critical and leading occupational disease, just following age-related hearing loss (ARHL) worldwide [3].…”

Section: Introductionmentioning

confidence: 99%

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Association of STAT3 Gene Polymorphism With Noise-induced Hearing Loss(NIHL) in the Chinese Population

Gao

Wang

Sun³

et al. 2020

Preprint

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Objectives NIHL is a disease with irreversible damage caused by multi-factor interaction, and the STAT3 is an essential protein with signal transduction and transcription functions. This study is aimed to explore the effect of STAT3 polymorphism on individual susceptibility to NIHL individuals, and to further examine the interaction between lifestyles and NIHL in the dominant model . Methods This study was designed a case-control study and included 609 NIHL cases and 611 healthy hearing controls from the Jiangsu province of China. By collecting the lifestyle and demographic information of the study participants, genotyping the collected blood samples, and performing Real-time Quantitative PCR (qRT-PCR) to analyze and investigate the potential association between STAT3 SNPs and NIHL. Results Statistical analysis results show that individuals carrying the C allele of rs1053023 and rs1053005 were more likely to develop NIHL than individuals carrying the T allele (OR = 1.367, 95% CI = 1.148–1.628, P = 0.0001 and OR = 1.37, 95% CI = 1.147–1.636, P = 0.001). In the dominant model (TC/CC genotype and TT genotype), stratified analysis of lifestyle, we found that people who smoke regularly are more likely to suffer from NIHL than non-smokers or occasional smokers. Besides, the expression of STAT3 was higher in NIHL cases by real-time quantitative PCR. Conclusion Gene polymorphisms, rs1053023 and rs1053005, from STAT3, are associated with NIHL and C alleles of rs1053023 and rs1053005 within STAT3 may become biomarkers for workers exposed to noise.

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Effect of Specific Retinoic Acid Receptor Agonists on Noise-Induced Hearing Loss

Cited by 10 publications

References 19 publications

Association of Dietary Factors with Noise Induced Hearing Loss in Korean Population: A 3-Year National Cohort Study

Association of Dietary Factors with Noise Induced Hearing Loss in Korean Population: A 3-Year National Cohort Study

Association of STAT3 Gene polymorphism with noise-induced hearing loss(NIHL) in the Chinese population

Association of STAT3 Gene Polymorphism With Noise-induced Hearing Loss(NIHL) in the Chinese Population

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