Effect of Spectrum Bias on the Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

Rao, Harsha L.; Kumbar, Tukaram; Addepalli, Uday K.; Bharti, Neha; Senthil, Sirisha; Choudhari, Nikhil S.; Garudadri, Chandra S.

doi:10.1167/iovs.11-8463

Cited by 68 publications

(47 citation statements)

References 37 publications

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“…Finally, our study's design was a case-control study including patients with well-established glaucoma, and using a separate group of normal subjects as hospital based-controls could overestimate the diagnostic performance substantially. 24,25 In conclusion, we demonstrated that the diagnostic performances of average cpRNFL thickness and average GCC thickness to identify early glaucoma and all-stage glaucoma were similar among Cirrus, RTVue, and 3D-OCT measurements in our study population. RTVue yielded a higher AUC value for nasal cpRNFL thickness than Cirrus and 3D-OCT in the detection of glaucoma.…”

Section: Discussionsupporting

confidence: 56%

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Akashi¹,

Kanamori²,

Nakamura³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS.We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), mean deviation > À6 dB). Each participant was imaged using Cirrus, RTVue, and 3D-OCT to evaluate the average and quadrant cpRNFL thicknesses. The macular retinal nerve fiber layer (mRNFL), ganglion cell layer plus inner plexiform layer (GCL/IPL), and mRNFL þ GCL/IPL (ganglion cell complex [GCC]) thicknesses were analyzed. The areas under the receiver operating characteristic curves (AUCs) were compared among the instruments.RESULTS. These instruments revealed similar AUCs for the average cpRNFL and GCC thicknesses in EGs, and total all-stage glaucomatous eyes (TGs). RTVue showed better performance in the nasal cpRNFL thickness than Cirrus and 3D-OCT, and better performance in the temporal cpRNFL thickness than 3D-OCT in TGs. RTVue had a higher AUC for the superior GCC thickness compared to Cirrus and 3D-OCT in EGs, and TGs. Cirrus had higher AUCs for GCL/IPL parameters in TGs, and lower AUCs for the mRNFL parameters in EGs and TGs compared to 3D-OCT.CONCLUSIONS. The average cpRNFL and GCC thicknesses measured using these OCT instruments exhibited similar abilities in the diagnosis of glaucoma, and RTVue exhibited better diagnostic abilities than Cirrus and 3D-OCT for nasal cpRNFL, and superior GCC thicknesses. The diagnostic performance of Cirrus and 3D-OCT was different for GCL/IPL and mRNFL parameters.

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Section: Discussionsupporting

confidence: 56%

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Akashi¹,

Kanamori²,

Nakamura³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…We have recently demonstrated how a control cohort with no suspicious findings of glaucoma can affect the diagnostic ability of SDOCT parameters in glaucoma compared with a control cohort which is likely to be misinterpreted as glaucoma. 16 Due to the same reason, AUCs of RNFL parameters reported in our study are also lower compared with the studies that have reported the same with SDOCT 7,10,29 and GDx ECC 5,12,13,30 separately.…”

Section: Discussioncontrasting

confidence: 44%

“…This protocol has been explained earlier. 16,18 The RNFL parameters generated by the ONH protocol and used in the study were temporal average (temporal 90 degree), superior average (superior 90 degree), nasal average (nasal 90 degree), inferior average (inferior 90 degree), and global average (over 360 degree). The RNFL parameters are also compared with the internal normative database of 1081 subjects of different ethnicities within the software and one of the three diagnostic categorizations is provided.…”

Section: Methodsmentioning

confidence: 99%

“…We have previously demonstrated how the selection of a control group without any suspicious findings of disease affected the diagnostic accuracy of SDOCT in glaucoma. 16 The purpose of the current study was to compare the abilities of RNFL parameters of SDOCT and GDx ECC in detecting glaucoma. The control group against which the glaucoma cohort was evaluated consisted of subjects referred to our institute from general ophthalmologists as glaucoma suspects based on the optic disc appearance.…”

Section: Introductionmentioning

confidence: 99%

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Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Rao

Yadav

Addepalli

et al. 2014

Eye

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Purpose To compare the abilities of retinal nerve fiber layer (RNFL) parameters of spectral domain optical coherence tomograph (SDOCT) and scanning laser polarimeter (GDx enhanced corneal compensation; ECC) in detecting glaucoma. Methods In a cross-sectional study, 215 eyes of 165 subjects (106 eyes of 79 glaucoma patients and 109 eyes of 86 controls) referred by general ophthalmologists for glaucoma evaluation underwent RNFL imaging with SDOCT and GDx ECC. Ability of RNFL parameters of SDOCT to discriminate glaucoma eyes from control eyes was compared with that of GDx ECC using area under operating characteristic curves (AUCs), sensitivities at fixed specificities, and likelihood ratios (LRs). Results AUC of the average RNFL thickness of SDOCT to differentiate glaucoma from control eyes (0.868) was comparable (P ¼ 0.32) to that of GDx ECC (0.855). Sensitivity at 95% specificity was 63.2% for average RNFL thickness of SDOCT and 48.1% for the average RNFL measurement of GDx ECC. LRs of outside normal limits category of SDOCT parameters ranged between 5.6 and 7.7 while the same of GDx ECC parameters ranged between 3.1 and 3.7. LRs of within normal limits category of SDOCT parameters ranged between 0.18 and 0.24 while the same of GDx ECC parameters ranged between 0.20 and 0.32. Conclusion Though AUCs and sensitivities at fixed specificities were comparable between the RNFL parameters of SDOCT and GDx ECC in diagnosing glaucoma, LRs indicated that the RNFL parameters of SDOCT were better in 'ruling in' glaucoma.

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“…FLV measures focal loss using a pattern deviation map, similar to PSD in the VF. 38,39 We explored these parameters because some authors consider that MS-associated ON may share some pathogenetic, structural, and functional similarities with glaucomatous optic neuropathy. 33,35 Global and focal losses in the GCC map were significantly higher in the ON group compared with NON and control groups.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Structural and Functional Assessment of the Visual System in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients

Huseyinoglu

Ekinci

Özben

et al. 2014

Neuro-Ophthalmology

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Studies that explored the anterior visual pathway in the patients with multiple sclerosis (MS) have demonstrated contradictory results about the correlation between structural and functional status of optic nerve and retina. We aimed to investigate the functional and structural findings in our cohort of mildly disabled relapsing-remitting MS patients. A total of 134 eyes (80 eyes of the patients with MS and 54 eyes of the control group) were investigated. Eyes of MS patients were divided into two groups-as eyes with history of optic neuritis (ON group) and without history of optic neuritis (NON group). Ophthalmological investigation including visual evoked potentials, standard automated perimetry, and optical coherence tomography were performed for all participants. Retinal and macular thicknesses were significantly decreased in ON and NON groups compared with controls. Also, visual evoked potential latencies and visual field loss were worse in the both MS groups compared with control group. We did not find any correlation between visual evoked potentials and retinal or macular thickness values but visual field parameters were correlated between retinal and macular layer loss in the NON group. According to our results and some previous studies, although both functional and structural changes were detected in patients with MS, functional status markers do not always show parallelism (or synchrony) with structural changes, especially in eyes with history of optic neuritis.

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Effect of Spectrum Bias on the Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

Cited by 68 publications

References 37 publications

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Relationship between Structural and Functional Assessment of the Visual System in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients

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