Effect of Spirulina Supplementation on the Nutrient Adequacy and Health Status of Non-Insulin-Dependent Diabetes Mellitus (NIDDM) Male Subjects

Kaur, Kamalpreet; Sachdeva, Rajbir; Kochhar, Anita

doi:10.1080/09735070.2009.11886348

Cited by 11 publications

(7 citation statements)

References 2 publications

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“…Our results support the few previous clinical studies wherein daily S. platensis supplementation reduced FBG and HbA1c levels in type 2 diabetic patients (Anitha & Chandralekha, 2010;Beihaghi & Taherzadeh, 2017;Kaur, Sachdeva, & Grover, 2008;Parikh, Mani, & Iyer, 2001). According to the authors, this study represents the first report showing that S.platensis plus metformin reduced HbA1c and FBS levels and showed synergistic benefits for TC, LDL-C, TG, and HDL-C. As such, our results are not comparable with other clinical trials.…”

Section: Discussionsupporting

confidence: 92%

“…According to the evidence, spirulina appears to be more effective at lower doses for controlling diabetes and its complications (Beihaghi & Taherzadeh, 2017). The selected dose of S. platensis was based on the Kamalpreet et al (Kaur et al, 2008); the study, which revealed the efficacy and safety of 2 g/day of spirulina as a complementary treatment in diabetic patients. To avoid adverse side effects regardless of the duration of S. platensis treatment, in our study, the low dose of S. platensis given for a short time proved beneficial in terms of glucose‐lowering and anti‐atherogenic effect.…”

Section: Discussionmentioning

confidence: 99%

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A randomized, double‐blind placebo‐controlled add‐on trial to assess the efficacy, safety, and anti‐atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus

karizi

Armanmehr

Azadi

et al. 2023

Phytotherapy Research

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The efficacy of spirulina platensis (S. platensis) as an add-on therapy to metformin and its effect on atherogenic keys in patients with uncontrolled Type 2 Diabetes Mellitus (T2DM) was evaluated. Sixty patients were randomly assigned to S. platensis (2 g/day) or placebo group for three months while continuing metformin as their usual treatment. The efficacy of S. platensis was determined using the pre-and postintervention HbA1c levels (primary outcome) as well as tracking FBS and lipid profiles levels (TC, LDL-C, TG, and HDL-C) as secondary outcomes at the different treatment time points (0,30,60,90 days). During the three-month intervention period, supplementation with S. platensis resulted in a significant lowering of HbA1c (#1.43, p < 0.001) and FBS (# 24.94 mg/dL, p < 001) levels. Mean TG in the intervention group was found to be significantly lower in the intervention group than in controls (p < 0.001). Total cholesterol (TC) and its fraction, LDL-C, exhibited a fall (#41.36 mg/ dL and #38.4 mg/dL, respectively; p < 0.001) coupled with a marginal increase in the level of HDL-C ("3 mg/dL; p < 0.001). Add-on therapy with S. platensis was superior to metformin regarding long-term glucose regulation and controlling blood glucose levels of subjects with T2DM. Also, as a functional supplement, S. platensis has a beneficial effect on atherogenic keys (TG and HDL-C) with no adverse events.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A randomized, double‐blind placebo‐controlled add‐on trial to assess the efficacy, safety, and anti‐atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus

karizi

Armanmehr

Azadi

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Spirulina demonstrated glucose and lipid-modulating effects, indicating that it might have a diabetes control potential in both animal and human studies (60)(61)(62). A study conducted in 2017, on male subjects with non-insulin-dependent diabetes mellitus (NIDDM) suggested supplementation of 2g of Spirulina can improve nutrient adequacy and health status of male subjects (63). Numerous studies have reported increased oxidative stress present in diabetic subjects (64)(65)(66).…”

Section: Diabetes Controlmentioning

confidence: 99%

“…Some studies have also shown the anti-inflammatory and neuroprotective effects to be particularly useful in treating schizophrenia (84). A study by Haider et al (2021) reported S. platensis administration could improve dizocilpine-induced behavioral deficits, regulate neurotransmission, and restore immune response dysfunction by effectively reducing cytokine production (63,64). Furthermore, an oral administration of 200mg/kg of C-phycocyanin, a phycobiliprotein extracted from S. platensis, improves the quality of life for individuals with Multiple Sclerosis (MS) by exhibiting a neuroprotective effect through the modulation of redox mechanism and myelination, demyelination involved in the disease occurrence (65).…”

Section: Neuroprotectivementioning

confidence: 99%

Spirulina, an FDA-approved functional food: Worth the hype?

Ahmad¹,

Intikhab²,

Zafar³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…SP contains phycocyanin, mixed carotenoids, phytonutrients, essential amino acids, gamma-linolenic acid, linoleic acid, and palmitic acid, which can improve the defense system and induce potent scavenging activities to reactive oxygen species (15,16). Moreover, the regular consumption of SP can improve the hematological profile owing to the presence of calcium, iron, copper, magnesium, and several vitamins (B6 and B12 and folic acid) essential for hemopoiesis (17). As a food additive, SP has antitumor, antibacterial, antiviral, anticancer, anti-HIV, and anti-inflammatory activities (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Hepatosplenic Protective Actions of Spirulina platensis and Matcha Green Tea Against Schistosoma mansoni Infection in Mice via Antioxidative and Anti-inflammatory Mechanisms

et al. 2021

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Schistosomiasis, a major parasitic illness, has high morbidity and negative financial effects in subtropical and tropical countries, including Egypt. The present study investigated the therapeutic effects of Spirulina platensis (SP) and matcha green tea (MGT) in Schistosoma mansoni-infected mice combined with tracing their possible antioxidant and anti-inflammatory impacts and their protective potency. A total of 60 Swiss albino mice were randomly allocated into six groups (n = 10): control group (CNT, received normal saline); SP–MGT group [received oral SP (3 g/kg bodyweight/day) plus MGT (3 g/kg bodyweight/day)]; S. mansoni group (infected with S. mansoni cercariae, 100 ± 10/mouse, using the tail immersion method); SP-infected group (infected with S. mansoni and received oral SP); MGT-infected group (received oral MGT after S. mansoni infection); and SP–MGT-infected group (received combined treatment of SP and MGT after S. mansoni infection). Treatment with SP and MGT started 4 weeks after S. mansoni infection and ended 10 weeks after. SP and MGT treatment (SP-infected and MGT-infected groups) and the combined treatment (SP–MGT-infected group) minimized the hepatic damage induced by S. mansoni; circulating alanine aminotransferase and aspartate transaminase decreased, and total protein, albumin, and globulin serum levels increased. The serum level of malondialdehyde significantly declined, and catalase, glutathione peroxidase, superoxide dismutase, and total antioxidant capacity increased in SP-infected, MGT-infected, and SP–MGT-infected groups compared with the infected group. Co-administration of SP and MGT reduced serum cytokine levels (tumor necrosis factor-alpha, interferon-gamma, and interleukin-13) and increased interleukin-10 levels after S. mansoni infection compared with the infected group. Moreover, treatment with SP and/or MGT decreased the number of granulomas in hepatic and splenic tissues compared with the infected group. Collectively, our results suggest that combined SP and MGT treatment is effective for S. mansoni infection. Liver and spleen tissue alterations were improved, the antioxidant systems were stimulated, and the inflammatory response was suppressed. Further research is recommended to investigate the mechanisms of the combined SP and MGT treatment effects to facilitate the development of novel therapies against this disease.

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Effect of Spirulina Supplementation on the Nutrient Adequacy and Health Status of Non-Insulin-Dependent Diabetes Mellitus (NIDDM) Male Subjects

Cited by 11 publications

References 2 publications

A randomized, double‐blind placebo‐controlled add‐on trial to assess the efficacy, safety, and anti‐atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus

A randomized, double‐blind placebo‐controlled add‐on trial to assess the efficacy, safety, and anti‐atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus

Spirulina, an FDA-approved functional food: Worth the hype?

Hepatosplenic Protective Actions of Spirulina platensis and Matcha Green Tea Against Schistosoma mansoni Infection in Mice via Antioxidative and Anti-inflammatory Mechanisms

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