Effect of SSRIs and SNRIs on Nocturnal Urinary Frequency

Abstract

SSRI/SNRI agents as a combined group do not appear to have a significant impact on nocturnal urinary frequency. The SSRIs and SNRIs may have an opposite effect on nocturnal frequency.

Psychiatric History and Overactive Bladder Symptom Severity in Ambulatory Urogynecological Patients

“…In contrast, peripheral serotonin, through stimulation of bladder 5-HT 2 , 5-HT 4 , and 5-HT 7 serotonin receptors, may promote detrusor contraction and facilitate micturition [51,52]. From this perspective, the results of the present and previous studies [49,50] may reflect peripheral rather than central serotonergic control of micturition. It is possible that in some patients treated with SSRI antidepressants increased serotonin levels and stimulation of specific 5-HT receptors in the bladder enhance SUI symptoms.…”

“…In a cross-sectional, population-based study based on mailed questionnaires, Felde et al [49] found that the use of antidepressants, but not anxiolytics, was associated with a general risk of urinary incontinence. A study of psychiatric patients [50] undergoing nocturnal polysomnography in a sleep center revealed that treatment with the SSRI drug, sertraline, increased nocturnal urinary frequency as compared to the serotonin-noradrenaline reuptake inhibitor (SNRI), duloxetine. The difference between sertraline and duloxetine could reflect a class effect, with SSRI antidepressants increasing and SNRI antidepressants decreasing nocturnal urinary frequency [50].…”

“…A study of psychiatric patients [50] undergoing nocturnal polysomnography in a sleep center revealed that treatment with the SSRI drug, sertraline, increased nocturnal urinary frequency as compared to the serotonin-noradrenaline reuptake inhibitor (SNRI), duloxetine. The difference between sertraline and duloxetine could reflect a class effect, with SSRI antidepressants increasing and SNRI antidepressants decreasing nocturnal urinary frequency [50]. Serotonin is thought to be involved in the central and peripheral control of micturition.…”

Nocturia and Sleep: Focus on Common Comorbidities and Their Association with Obstructive Sleep Apnea

“…Different classes of antidepressants can result in disparate prevalence of nocturia. One study reported a divergent result of nocturnal urinary frequency between those on SSRIs and those on noradrenaline reuptake inhibitors (NRI), with patients on SSRI reporting higher nocturnal urinary frequency than did those on NRI [71]. Moreover, compared with duloxetine, frequency increased 3-fold in the sertraline group [71].…”

“…One study reported a divergent result of nocturnal urinary frequency between those on SSRIs and those on noradrenaline reuptake inhibitors (NRI), with patients on SSRI reporting higher nocturnal urinary frequency than did those on NRI [71]. Moreover, compared with duloxetine, frequency increased 3-fold in the sertraline group [71]. These results arise from different drugs and side-effect profiles, but because nocturia increases depression and affects sleep quality in depressed patients, it is advisable to keep close surveillance of symptoms of nocturia in patients with depression.…”