Effect of Standardized Mixture of Potassium and Sodium Citrate and Citric Acid (Uralyt-U) on the Correction of Postoperative Acidosis in Patients Who Underwent Ureterosigmoidostomy

Sasagawa, Isoji; Nakada, Teruhiro; Ishigooka, Manabu; Kubota, Yōko; Sawamura, T.

doi:10.1159/000187871

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Measurement Of Intratumor Ph Using a Microelectrode1

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2021

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“…Tumor growth inhibition [TGI (%)] was calculated using the following formula (RTV: relative tumor volume). 19) correct the acid buildup in the blood. 11) The dosage of K/Na citrate was decided by reference to the previous publication.…”

Section: Measurement Of Intratumor Ph Using a Microelectrodementioning

confidence: 96%

Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model

Ando

Eshima

Ishida

2021

Biological & Pharmaceutical Bulletin

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Extracellular pH (pHe) of tumor cells is characteristic of tumor microenvironment (TME). Acidic TMEimpairs the responses of tumors to some anti-cancer chemotherapies. In this study, we showed that daily oral dosing of sodium potassium citrate (K/Na citrate) increased blood HCO 3 concentrations, corresponding to increase of HCO 3 concentrations and pHs in urine, and neutralized the tumor pHe. Neutralization of acidic TME by alkaline substance like HCO 3 , an active metabolite of K/Na citrate, well potentiated the therapeutic effect of anticancer agent TS-1 ® , an orally active 5-fuluoro-uracil derivative, in Panc-1 pancreatic cancer-xenograft murine model. Neutralization of acidic TME by using an alkaline K/Na citrate is a smart approach for enhancement of the therapeutic effects of anticancer agents for pancreatic cancer in the end stage.

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Section: Measurement Of Intratumor Ph Using a Microelectrodementioning

confidence: 96%