Effect of starvation on the tissue composition of the small intestine in the rat

Steiner, Mark; Bourges, H; Ls, Freedman; Sj, Gray

doi:10.1152/ajplegacy.1968.215.1.75

Cited by 163 publications

(62 citation statements)

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“…In good agreement with a previous report that fasting causes a decrease in intestinal weight [19], we found that the mucosal weight decreased after 3 days of fasting and increased very quickly after refeeding. The response of refeeding seemed to be more rapid than that of fasting.…”

Section: Discussionsupporting

confidence: 93%

“…It is reported that mucosal cell proliferation in crypts is greatly influenced by fasting in rats. Number of mucosal cells, DNA content, and mucosal uptake of [3H]thymidine were shown to be reduced as was the migration rate of cells up to the villous tip [19][20][21]. Therefore, the entire surface area of the j ej unal vill us was much smaller in fasted than in control animals.…”

Section: Discussionmentioning

confidence: 94%

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Adaptive Changes of Sugar Absorption in Rat Small Intestine during Fasting and Refeeding

Yamada

Shinohara

Hyodo

et al. 1986

J. Clin. Biochem. Nutr.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Adaptive Changes of Sugar Absorption in Rat Small Intestine during Fasting and Refeeding

Yamada

Shinohara

Hyodo

et al. 1986

J. Clin. Biochem. Nutr.

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“…The present study confirms these observations. Steiner et al (1968) starved rats for 6 days and showed that the small intestine lost weight faster than the body as a whole; the present experiment indicated that this was true when the dietary restriction imposed was less severe but was of longer duration.…”

supporting

confidence: 55%

Effects of Semi-Starvation on the Total Body Composition and Absorptive Function of the Small Intestine of the Young Adult Female Rat

Williams¹,

Senior²,

Sippel³

1976

Aust. Jnl. Of Bio. Sci.

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Sixteen female rats aged about 80 days and with a mean body weight of 175 g were fed 40 % of their ad libitum intake of a laboratory chow. They were killed and analysed for water, protein, lipid and ash after 9, 21· 5, 30· 2 and 38·8 % of body weight had been lost. Compared to a control group of four animals, the 38·8 % group lost 13 g or 34 % of their protein. The animals in the 21 . 5, 30· 2 and 38 . 8 % groups lost 7· 5 g or 87 % of their lipid leaving only 1 ·1 g of lipid. The percentage protein in the body was little affected by body weight loss but lipid decreased from 5 to 1 %.In another experiment with 26 rats of 205 g mean body weight and aged about 115 days, absorption rates by the small intestine were measured in vivo after variable weight losses between 0 and 39 %. o( + )-Glucose uptake was increased by about 70 % in those animals which had lost only 5 % of body weight and this increased uptake was retained in those rats which had lost up to 39 % of body weight.The absorption of L-leucine was not affected by the decline in body weight compared to the controls but relative to body weight, the ability of the intestine to absorb increased.In the same animals, the wet and dry weights of the small intestine declined slightly faster than body weight and the length of the small intestine tended to decrease slightly with increasing loss of body weight.

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“…McCracken (1984) and McCracken and Kelly (1984) suggested that villous atrophy and reductions in digestive enzyme activity after weaning may be related more to the lack of a continuous supply of substrate than to any antigenicity of the diet or inherently low levels of disaccharidase activity. In rodents and miniature piglets a period of food restriction (Steiner, Bourges, Freedman and Gray, 1968;McManus and Isselbacher, 1970;Altmann, 1972), or exclusion of nutrients from the gut when animals were fed parenterally (McNeill and Hamilton, 1971;Shulman, Fiorotto, Sheng and Garza, 1984;Goldstein, Hebiguchi, Luk, Taqi, Guilarte, Franklin, Niemiec and Dudgeon, 1985;Castillo, Feng, Stevenson, Kerner and Kwong, 1990), resulted in villous atrophy and decreases in mucosal protein content and digestive enzyme activity. These findings suggest a direct role for the presence of nutrients in the lumen for the maintenance of gut structure and function after weaning.…”

Section: Introductionmentioning

confidence: 99%

Maintenance of villous height and crypt depth in piglets by providing continuous nutrition after weaning

1996

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(3) and (4) (P < 0-05 and P = 0-073, respectively). In turn, villous height was significantly correlated (r = 0-78 to 0-87, P < 0-05) with the rate of bodyweight gain after weaning in these two groups. For piglets offered ewes' milk plus glutamine, an increase in DM intake was associated only with increases in crypt depth (P < 0-01). These data show that the structure and function of the small intestine can be preserved when a milk diet is given after weaning, and suggest an association between food intake and villous height in determining post-weaning weight gain. were offered ewes' fresh milk every 2 h in a feeding schedule that increased from 1-2 I per piglet on the 1st day after weaning to 2-4 I on days 4 and 5. On the 5th day all piglets were killed and samples of small intestine were taken for histological and biochemical examination. Feeding ewes' milk or ewes' milk plus 20 g L-glutamine per I maintained (P > 0-05) villous height and crypt depth compared with piglets killed at weaning. In contrast, piglets given a dry starter diet had shorter villi (P < 0-001), deeper crypts (P < 0-001), and proportionately 0-21 to 0-28 less protein (P>0-05) in their intestinal mucosa. Piglets given the starter diet proportionately grew from 0-49 to 0-62 more slowly (P < 0-01), ate the same amount of dry matter (DM; P > 0-05), but consumed proportionately 0-30 less energy (P < 0-001) than their counterparts given the milk diets. No treatment differences in the specific activity of lactase and sucrase were observed (P>0-05). Significant correlations existed between voluntary food intake and villous height at the proximal jejunum for piglets given the starter diet and ewes' milk

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Effect of starvation on the tissue composition of the small intestine in the rat

Cited by 163 publications

References 0 publications

Adaptive Changes of Sugar Absorption in Rat Small Intestine during Fasting and Refeeding

Adaptive Changes of Sugar Absorption in Rat Small Intestine during Fasting and Refeeding

Effects of Semi-Starvation on the Total Body Composition and Absorptive Function of the Small Intestine of the Young Adult Female Rat

Maintenance of villous height and crypt depth in piglets by providing continuous nutrition after weaning

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