Effect of STAT1, OLR1, CSN1S1, CSN1S2 , and DGAT1 genes on milk yield and composition traits of Holstein breed

Ardıçlı, Sena; Soyudal, Bahadır; Şamlı, Hale; Dinçel, Deniz; Balcı, Faruk

doi:10.1590/rbz4720170247

Cited by 17 publications

(10 citation statements)

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“…Only few animals in the population were heterozygous. Similar results were obtained by Ardicli et al [ 9 ], who also investigated the same SNP and reported that in HF population most frequent was DD genotype (97.62% of all animals). Out of 168 tested animals, only four were heterozygous, having AD genotype.…”

Section: Resultssupporting

confidence: 89%

“…This may suggest that in the studied population one of the genotypes was favored during reproduction programs in the past. Other authors also described results of χ 2 test used to verify any deviation from H-W equilibrium, for instance, Ardicli et al [ 9 ] who investigated polymorphism in CSN1S1, noted that the tested HF population was not in H-W equilibrium (not all genotypes were present in the population, χ 2 was at the level of 0.42, and p -value at 0.52), similarly with CSN1S2 genotypes. Furthermore, Hristov et al [ 7 ] subjected their result to χ 2 test in order to evaluate the validity of H-W equilibrium.…”

Section: Resultsmentioning

confidence: 99%

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The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

Kolenda

Sitkowska

2021

Animals

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The aim of the present study was to evaluate the genotype and allele frequencies of 24 polymorphisms in casein alpha S1 (CSN1S1), casein alpha S2 (CSN1S2), beta-casein (CSN2), kappa-casein (CSN3), and progestagen-associated endometrial protein (PAEP) genes. The study included 1900 Polish Black and White Holstein-Friesian dairy cows that were subjected to genotyping via microarrays. A total of 24 SNPs (Single Nucleotide Polymorphisms) within tested genes were investigated. Two CSN1S1 SNPs were monomorphic, while allele CSN1S1_3*G in CSN1S1_3 SNP dominated with a frequency of 99.39%. Out of seven CSN2 SNPs, four were polymorphic; however, only for CSN2_3 all three genotypes were detected. Only three out of nine SNPs within CSN3 were monomorphic. Three PAEP SNPs were also found to be polymorphic with heterozygotes being most frequent. Hardy–Weinberg equilibrium (HWE) was observed for eight variants. It was shown that only CSN3_6 was not in HWE. The fact that many of investigated SNPs were monomorphic may suggest that in the past the reproduction program favored one of these genotypes. SNPs that are included in commercially available microarrays should be monitored in relation to changes in their frequencies. If a SNP has turned monomorphic, maybe it should be considered for removal from the microarray.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

Kolenda

Sitkowska

2021

Animals

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“…In the study performed, the frequency of C allele was generally found high for the STAT1 gene in all populations as compared with T allele and the ratios of CC, CT, and TT genotypes were found as 53%, 40%, and 0.07%, respectively. In one of the recent studies, the frequencies of CC, CT and COBANOGLU, KUL, ABACI GURCAN, CANKAYA TT genotypes of the STAT1 gene were reported similarly in the same pattern but somewhat lower as 45.24% for CC, 36.31% for CT genotypes, but a little higher as 18.45% for TT genotype in Holstein cows raised in the other farm also located to west part of Turkey, respectively [20] . They reported that the population did not follow Hardy-Weinberg Equilibrium for this locus which might be due to sampling, inbreeding or population stratification.…”

Section: Discussionmentioning

confidence: 76%

Türkiye’de Holstein, Jersey ve Yerli Sığır Irklarında STAT1 ve STAT5A Genlerinin Genetik Polimorfizmi

Cobanoglu¹,

Kul²,

Abacı³

et al. 2019

Kafkas Univ Vet Fak Derg

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This study aimed to determine genetic polymorphism in STAT1 and STAT5A genes for dairy cattle and some native cattle breeds in Turkey. 283 Jersey and a total of 472 Holstein cows from two different herds and 93 Grey Steppe, 85 Anatolian Black Cattle, and 66 East Anatolian Red cattle were used in this research. Generally, C allele gene frequency was higher than T allele for STAT1 in all breeds whereas C allele gene frequency was detected higher than G allele for STAT5A in Jersey and East Anatolian Red. On the other hand, G allele gene frequency was higher than C allele in Holstein, Grey Steppe, and Anatolian Black Cattle breeds. The expected deviations from the Hardy-Weinberg Equilibrium were significant only for Jersey breeds for STAT1 gene. Meanwhile, the expected deviation from equilibrium was also significantly different for Holstein in Black Sea Region (BSR), Anatolian Black Cattle and Grey Steppe for the STAT5A gene. FIS values were determined to STAT1 gene as negative for all breeds except for Holstein in Marmara Region (MR). Similarly, this value was determined to STAT5A gene as positive for all breeds except for Holstein in BSR. The genetic distances for two loci were calculated between 0.0029 and 0.1599 among all populations. Depending on the cluster analysis, Holstein in BSR and MR, Anatolian Black Cattle, East Anatolian Red were closely clustered to each other, while Grey Steppe and Jersey were located in completely different clusters. As a conclusion, based on the detected genetic diversity in STAT1 and STAT5A genes, it is possible to make a genetic improvement among bovine breeds raised in Turkey.

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“…Hamza et al (2011) reported that CN genotypes had significant effect on milk fat component. Previously, Ardicli et al (2018) reported that CSN1S1 genotypes were associated to milk fat. Besides, Dagnachew et al (2011) the genetic variants of CSN3 affected milk fat levels.…”

Section: Association Of Genetic Variants Of Milk Protein Genes On Milmentioning

confidence: 98%

Genetic Variants of Milk Protein Genes and Their Association with Milk Components in Holstein Friesian Cattle

Asmarasari¹,

Sumantri²,

Gunawan³

et al. 2020

JITV

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Protein content in milk is an important indicator of milk. Accordingly, genetic improvement to produce Holstein Friesian (HF) dairy cattle is important. The objective of this study was to evaluate the genetic variant of milk protein genes and its effect on milk component traits of Holstein Friesian (HF). A total of 100 HF were used in this study. The HF cattle used have physiological status in the lactation period 1 up to 3 and lactation change of 1 up to 12 months. Genotype variants of milk protein genes were identified using Real Time-Polymerase Chain Reaction method. Analysis of milk component was carried out covering the component of protein, fat, lactose, and solid non-fat (SNF) by using a milk quality measuring device (Lactoscan). Genotyping of cattle blood samples consisted of DNA extraction, genes amplification using the RT-PCR method. The result showed that<strong> </strong>protein milk was significantly affected (p<0.05) by the genetic variants of CSN1S1-192 and CSN2-67 genes. Fat milk was significantly affected (p<0.05) by the genetic variants of CSN1S1-192 and CSN3 genes. Meanwhile, solid non-fat milk was significantly affected (p<0.05) by the genetic variants of CSN-BMC9215, CSN-BMC6334, CSN1S1-14618, CSN2_67, and CSN3 genes. Lactose milk was significantly affected (p<0.05) by the genetic variants of CSN-BMC9215 and CSN2-67 genes. It was concluded that genetic variants of the milk protein genes have an association with the component of cow's milk (protein, fat, solid non-fat, and lactose).

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Effect of STAT1, OLR1, CSN1S1, CSN1S2 , and DGAT1 genes on milk yield and composition traits of Holstein breed

Cited by 17 publications

References 50 publications

The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

The Polymorphism in Various Milk Protein Genes in Polish Holstein-Friesian Dairy Cattle

Türkiye’de Holstein, Jersey ve Yerli Sığır Irklarında STAT1 ve STAT5A Genlerinin Genetik Polimorfizmi

Genetic Variants of Milk Protein Genes and Their Association with Milk Components in Holstein Friesian Cattle

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