Effect of Statin Use on Biochemical Outcome Following Radical Prostatectomy

Goldstein, Mark R.; Mascitelli, Luca

doi:10.1111/j.1464-410x.2011.10449.x

Cited by 2 publications

(1 citation statement)

References 30 publications

(25 reference statements)

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“…Most consequences of this interference seem to be antiproliferative in nature and would be expected to reduce prostate cancer aggressiveness [2,3]. However, it has been noted that pro‐neoplastic effects of statins on prostate cancer are also conceivable [30]. Because in vitro and animal studies cannot definitively determine whether the net effect of statins on prostate cancer in humans is pro‐ or anti‐neoplastic, evidence from epidemiological research must be examined to address this question.…”

Section: Discussionmentioning

confidence: 99%

Statin use and the risk of biochemical recurrence of prostate cancer after definitive local therapy: a meta‐analysis of eight cohort studies

Scosyrev¹,

Tobis²,

Donsky³

et al. 2012

BJU International

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What ' s known on the subject? and What does the study add?Over the last few years, several observational studies examined the association of statin use with the risk of biochemical recurrence of prostate cancer after defi nitive local therapy. The objective of our present study was to summarise available evidence on this subject using the method of meta-analysis.Combined evidence from eight cohort studies did not defi nitively support the hypothesis that statins infl uence the risk of biochemical recurrence. However, there was considerable disagreement between individual studies in reported fi ndings and conclusions. OBJECTIVE• To perform a systematic review and meta-analysis of clinical studies with statin use as the exposure variable and biochemical recurrence after defi nitive local therapy for prostate cancer as the outcome. METHODS• Relevant publications were identifi ed through PubMed/Medline/Embase databases.• Pooled estimates of the hazard ratios (HRs) were computed using the inversevariance weighting approach.• Heterogeneity was assessed using the Cochran ' s Q test. RESULTS• We identifi ed a total of eight eligible studies, all based on the retrospective cohort design. Five of these were based on radical prostatectomy (RP) series and three on radiotherapy (RT) series.• There was evidence of heterogeneity in the entire set of eight studies ( P = 0.002) as well as in the RP series ( P = 0.05) and in the RT series ( P = 0.01), when these were considered separately.• Based on the random effects inversevariance weighting approach, pooled estimates of the HRs for the risk of biochemical recurrence in statin users v non-users were 0.91 (95% confi dence interval [ CI ] 0.72 -1.13) for the entire set of eight studies, 1.02 (95% CI 0.80 -1.29) for the RP series and 0.71 (95% CI 0.44 -1.16) for the RT series. CONCLUSION• The pooled estimates of the HRs were not signifi cantly different from the null value in this meta-analysis; however, evidence of heterogeneity between the studies was present.

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Section: Discussionmentioning

confidence: 99%