Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia

Ohno, Minoru; Yamamoto, Tsuneyuki; Watanabe, Soichi

doi:10.1016/0014-2999(91)90844-g

Cited by 20 publications

(1 citation statement)

References 10 publications

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“…Moreover, Ohno et al indicated that staurosporine administered (i.p. ; 0.03 mg/kg) immediately after blood flow reperfusion significantly reduced the impairment of working memory in rats following transient forebrain ischemia [ 46 ]. Both seizure-induced damage to hippocampal neurons and associated visuospatial memory deficits were significantly reduced in rats administered staurosporine (s.c. injections of 4 μg/kg/day) prior to kainic acid administration [ 44 ].…”

Section: Staurosporinementioning

confidence: 99%

Marine-derived protein kinase inhibitors for neuroinflammatory diseases

et al. 2018

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Neuroinflammation is primarily characterized by overexpression of proinflammatory mediators produced by glial activation or immune cell infiltration. Several kinases have been shown to be critical mediators in neuroinflammation. One of the largest groups of kinases is protein kinases, which have been the second most studied group of drug targets after G-protein-coupled receptors. Thus far, most of the approved kinase inhibitor drugs are adenosine triphosphate-competitive inhibitors with various off-target liabilities because of cross-reactivities; however, marine-derived compounds provide opportunities for discovering allosteric kinase inhibitors. This review summarizes the potential of marine-derived protein kinase inhibitors in the field of neuroinflammatory diseases, such as Parkinson disease, Alzheimer disease, multiple sclerosis, and pain. The previous studies from 1990 to 2017 in this review have shown that marine-derived protein kinase inhibitors have great potential to elicit anti-neuroinflammatory or neuroprotective responses in in vitro and in vivo models of neuroinflammatory diseases. This suggests that further exploration and investigation of these marine-derived protein kinase inhibitors on neuroinflammatory diseases are warranted. Therefore, this review may inspire further discovery of new protein kinase inhibitors from a marine origin and additional neuroscience studies focusing on these valuable marine-derived protein kinase inhibitors.

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Section: Staurosporinementioning

confidence: 99%

Marine-derived protein kinase inhibitors for neuroinflammatory diseases

et al. 2018

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Neuroprotective Strategies Based on Targeting of Postreceptor Signaling Events

Mattson¹

1998

Neuroprotective Signal Transduction

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Therapeutic potential of protein kinase C inhibitors

et al. 1993

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The serine/threonine protein kinase, protein kinase C (PKC) is a family of closely related isoforms which are physiologically activated by diacylglycerol generated by the binding of a variety of agonists to their cellular receptors. Free fatty acids may also play a role in activating PKC. The enzyme apparently mediates a wide range of signal transduction processes in cells and, therefore, inhibitors directed selectively against PKC may have wide-ranging therapeutic potential. This review highlights the evidence that inappropriate activation of PKC occurs in a number of disease states. Such evidence, however, is often seriously flawed because it relies on the use of phorbol esters, which are potent and direct PKC activators but may not mimic the physiological triggering of the enzyme in cells, or on the use of non-selective protein kinase inhibitors such as H7 and staurosporine. A new generation of bis-indolylmaleimides, derived from the lead provided by staurosporine, shows a high degree of selectivity for PKC over closely related protein kinases and such agents may provide more appropriate tools to investigate the role of PKC in cellular processes.

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Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia

Cited by 20 publications

References 10 publications

Marine-derived protein kinase inhibitors for neuroinflammatory diseases

Marine-derived protein kinase inhibitors for neuroinflammatory diseases

Neuroprotective Strategies Based on Targeting of Postreceptor Signaling Events

Therapeutic potential of protein kinase C inhibitors

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