Effect of stem cells-based therapy on astrogliosis in stroke subjected-mice

Akhoundzadeh, Kobra; Vakili, Abedin

doi:10.21037/sci-2020-031

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…The GFAP staining showed increased GFAP positive cells around lesion in the stroke monkeys from Day 2 to Day 4. As GFAP is known as a best-identified marker of astrogliosis ( Akhoundzadeh and Vakili, 2020 ), the increased GFAP positive cells might contribute to the functional recovery post stroke as reported previously in rodent models of stroke ( Bilen et al, 2013 ; Otsuka et al, 2016 ). However, the positive or negative effect of astrogliosis after stroke is still in debate especially in early stage of stroke ( Akhoundzadeh and Shafia, 2021 ).…”

Section: Discussionmentioning

confidence: 67%

Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke

Tong

Kempf

et al. 2023

Current Research in Neurobiology

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Section: Discussionmentioning

confidence: 67%

Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke

Tong

Kempf

et al. 2023

Current Research in Neurobiology

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“…Introduction of BDNF gene into human bone marrow derived MSCs reported to increase the neurogenesis in a rat MCAO model [ 218 ]. Administration of bone marrow stem cells induces astrogliosis in the MCAO mouse model [ 219 ]. Injection of human induced pluripotent stem cells showed an increase in neurogenesis and decreases of microglial activation in a pig model of stroke [ 220 ].…”

Section: Novel Exploratory Targets In Ischemic Strokementioning

confidence: 99%

A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies

Singh

Kharwar

Dandekar

2022

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Background: Stroke is a serious neurovascular problem and the leading cause of disability and death worldwide. The disrupted demand to supply ratio of blood and glucose during cerebral ischemia develops hypoxic shock, and subsequently necrotic neuronal death in the affected regions. Multiple causal factors like age, sex, race, genetics, diet, and lifestyle play an important role in the occurrence as well as progression of post-stroke deleterious events. These biological and environmental factors may be contributed to vasculature variable architecture and abnormal neuronal activity. Since recombinant tissue plasminogen activator is the only clinically effective clot bursting drug, there is a huge unmet medical need for newer therapies for the treatment of stroke. Innumerous therapeutic interventions have shown promise in the experimental models of stroke but failed to translate it into clinical counterparts. Methods: Original publications regarding pathophysiology, preclinical experimental models, new targets and therapies targeting ischemic stroke have been reviewed since the 1970s. Results: We highlighted the critical underlying pathophysiological mechanisms of cerebral stroke and preclinical stroke models. We discuss the strengths and caveats of widely used ischemic stroke models, and commented on the potential translational problems. We also describe the new emerging treatment strategies, including stem cell therapy, neurotrophic factors and gut microbiome-based therapy for the management of post-stroke consequences. Results : We highlighted the critical underlying pathophysiological mechanisms of cerebral stroke and preclinical stroke models. We discuss the strengths and caveats of widely used ischemic stroke models, and commented on the potential translational problems. We also describe the new emerging treatment strategies, including stem cell therapy, neurotrophic factors and gut microbiome-based therapy for the management of post-stroke consequences. Conclusion: There are still many inter-linked pathophysiological alterations with regards to stroke, animal models need not necessarily mimic the same conditions of stroke pathology and newer targets and therapies are the need of the hour in stroke research.

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Association between GFAP-positive astrocytes with clinically important parameters including neurological deficits and/or infarct volume in stroke-induced animals

Akhoundzadeh

Shafia

2021

Brain Research

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Effect of stem cells-based therapy on astrogliosis in stroke subjected-mice

Cited by 3 publications

References 27 publications

Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke

Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke

A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies

Association between GFAP-positive astrocytes with clinically important parameters including neurological deficits and/or infarct volume in stroke-induced animals

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