Effect of Stenosis Severity on Shear-Induced Diffusion of Red Blood Cells in Coronary Arteries

Buradi, Abdulrajak; Morab, Sumant; Mahalingam, Arun

doi:10.1142/s0219519419500349

Cited by 15 publications

(5 citation statements)

References 34 publications

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“…At the L2 position the velocity profile has a parabolic-shape profile. This shape differs from the profiles reported in the work of [45] who observed a plugshaped flow for axisymmetric lesions of various stenosis severities including the ones studied here. The reason for this difference in the profile with the results here, is that in the case of the axisymmetric idealised lesions, the RBCs move towards the centreline of the vessel whereas in this study, due to eccentricity, the red blood cells exhibit a core with high RBC levels at the centreline, but also at regions near the wall at the lower part of the vessel.…”

Section: Downstream (Positions L2 and L3contrasting

confidence: 99%

Haemodynamic analysis using multiphase flow dynamics in tubular lesions

Lyras¹,

Lee²

2021

Preprint

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Background and Objective: The role of red blood cell dynamics is emphasised in certain cardiovascular diseases, and thus needs to be closely studied. A multiphase model of blood flow allows the resolution of locally varying density of red blood cells within a complex vessel geometrical domain, and haemodynamic consequences of such build up.Methods: A novel computational fluid dynamics solver for simulating multiphase flows is used for modelling blood flow using level set for a sharp interface representation. Single-phase simulations and reduced order models are used for pressure comparisons. The new solver is used for numerically studying AHA type B lesions. The impact of hematocrit and degree of stenosis on the haemodynamics of coronary arteries is investigated. Results:The comparisons with single-phase flow simulations indicate differences in pressure when considering red blood cell aggregation. Multiphase simulations provide slightly lower pressure drop for the same stenosis severity compared to the single-phase simulations. Secondary flow patterns and the interactions between the two phases leads to the red blood cell aggregation at the end of the diastole cycle, which significantly changes the red blood cell distribution, the shear stresses and velocity in tubular lesions.Conclusions: Neither pressure drop nor mean velocity are not strongly

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Section: Downstream (Positions L2 and L3contrasting

confidence: 99%

Haemodynamic analysis using multiphase flow dynamics in tubular lesions

Lyras¹,

Lee²

2021

Preprint

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“…Third, lesion level analysis was performed in borderline non-flow limiting lesions; it is unclear whether our findings also apply to lesions with mild or severe stenosis. Finally, the present study did not take into account the non-Newtonian behaviour of the blood which can affect flow patterns in severely stenotic lesions [ 23 ]; this simplification however enabled fast WSS computation rendering this analysis clinically feasible.…”

Section: Discussionmentioning

confidence: 99%

Agreement of wall shear stress distribution between two core laboratories using three-dimensional quantitative coronary angiography

Kageyama

Tufaro

Torii

et al. 2023

Int J Cardiovasc Imaging

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Wall shear stress (WSS) estimated in models reconstructed from intravascular imaging and 3-dimensional-quantitative coronary angiography (3D-QCA) data provides important prognostic information and enables identification of high-risk lesions. However, these analyses are time-consuming and require expertise, limiting WSS adoption in clinical practice. Recently, a novel software has been developed for real-time computation of time-averaged WSS (TAWSS) and multidirectional WSS distribution. This study aims to examine its inter-corelab reproducibility. Sixty lesions (20 coronary bifurcations) with a borderline negative fractional flow reserve were processed using the CAAS Workstation WSS prototype to estimate WSS and multi-directional WSS values. Analysis was performed by two corelabs and their estimations for the WSS in 3 mm segments across each reconstructed vessel was extracted and compared. In total 700 segments (256 located in bifurcated vessels) were included in the analysis. A high intra-class correlation was noted for all the 3D-QCA and TAWSS metrics between the estimations of the two corelabs irrespective of the presence (range: 0.90–0.92) or absence (range: 0.89–0.90) of a coronary bifurcation, while the ICC was good-moderate for the multidirectional WSS (range: 0.72–0.86). Lesion level analysis demonstrated a high agreement of the two corelabls for detecting lesions exposed to an unfavourable haemodynamic environment (WSS > 8.24 Pa, κ = 0.77) that had a high-risk morphology (area stenosis > 61.3%, κ = 0.71) and were prone to progress and cause events. The CAAS Workstation WSS enables reproducible 3D-QCA reconstruction and computation of WSS metrics. Further research is needed to explore its value in detecting high-risk lesions.

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“…Therefore, the consideration of multiphase models is of great importance when modeling atherosclerotic lesions. Although some studies have already applied these models [42,83,[103][104][105], the research is still in the beginning. Moreover, it should be also noted that the use of these models is a promising option for studying nanoparticle-mediated targeted drug delivery treatment of atherosclerosis.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Blood Flow Modeling in Coronary Arteries: A Review

Carvalho

Pinho

Lima

et al. 2021

Fluids

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Atherosclerosis is one of the main causes of cardiovascular events, namely, myocardium infarction and cerebral stroke, responsible for a great number of deaths every year worldwide. This pathology is caused by the progressive accumulation of low-density lipoproteins, cholesterol, and other substances on the arterial wall, narrowing its lumen. To date, many hemodynamic studies have been conducted experimentally and/or numerically; however, this disease is not yet fully understood. For this reason, the research of this pathology is still ongoing, mainly, resorting to computational methods. These have been increasingly used in biomedical research of atherosclerosis because of their high-performance hardware and software. Taking into account the attempts that have been made in computational techniques to simulate realistic conditions of blood flow in both diseased and healthy arteries, the present review aims to give an overview of the most recent numerical studies focused on coronary arteries, by addressing the blood viscosity models, and applied physiological flow conditions. In general, regardless of the boundary conditions, numerical studies have been contributed to a better understanding of the development of this disease, its diagnosis, and its treatment.

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Effect of Stenosis Severity on Shear-Induced Diffusion of Red Blood Cells in Coronary Arteries

Cited by 15 publications

References 34 publications

Haemodynamic analysis using multiphase flow dynamics in tubular lesions

Haemodynamic analysis using multiphase flow dynamics in tubular lesions

Agreement of wall shear stress distribution between two core laboratories using three-dimensional quantitative coronary angiography

Blood Flow Modeling in Coronary Arteries: A Review

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