Effect of sterilization on the surface properties of Ti6Al7Nb alloy femoral stems

Avsec, Klemen; Conradi, Marjetka; Jenko, Monika; Kocjančič, Boštjan; Debeljak, Mojca; Gorenšek, Matevž; Dolinar, Drago

doi:10.17222/mit.2020.141

Cited by 6 publications

(12 citation statements)

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“…The sterilization experiment embodies the photoelectric effect charge separation experiment. In order to test the visible light absorption and bactericidal performance of TiO 2 /CNT mesoporous composite, a mixture of Escherichia coli and different composites was made [ 40 , 41 ]. The mixture was spread on the agar medium after simulating sunlight irradiation, and the bactericidal results are shown in Figure 6 .…”

Section: Resultsmentioning

confidence: 99%

Physicochemical and Antibacterial Evaluation of TiO2/CNT Mesoporous Nanomaterials Prepared by High-Pressure Hydrothermal Sol–Gel Method under an Ultrasonic Composite Environment

Lai¹,

Zhao

et al. 2023

Molecules

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TiO2 has attracted significant research interest, principally due to its nontoxicity, high stability, and abundance. Carbon-doped TiO2 can improve light absorption efficiency. In order to prepare high-efficiency photocatalysts, carbon-doped composites were prepared by hydrothermal reaction in a high-pressure reactor, and then TiO2/CNT mesoporous composites were prepared by the sol–gel method in an ultrasonic environment. Characterized by SEM and TEM, the composite materials contained TiO2 nanoparticles as well as CNT. After phase analysis, it was the anatase-doped phase. The following infrared light absorption performance and Escherichia coli bactericidal performance tests showed that it had better infrared and visible light absorption performance than pure TiO2. The TiO2/CNT mesoporous nanomaterials synthesized in this work are possible for clean industrial productions.

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Section: Resultsmentioning

confidence: 99%

Physicochemical and Antibacterial Evaluation of TiO2/CNT Mesoporous Nanomaterials Prepared by High-Pressure Hydrothermal Sol–Gel Method under an Ultrasonic Composite Environment

Lai¹,

Zhao

et al. 2023

Molecules

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“…In the literature, eventual implant loosening due to aseptic osteolysis has been attributed to local inflammatory responses to wear and corrosion products that are produced by articulating implant interfaces [20,21]. The response to implant debris is dominated by local immune activation, e.g., macrophages [11,12,16,35].…”

Section: Discussionmentioning

confidence: 99%

“…The corundum contamination was found on and under the surface of the new and retrieved dental implants [19]. The study of new and retrieved dental implants and restorative materials-commercially pure titanium (cpTi), the Ti 6 Al 4 V alloy and CoCrMo-by light microscopy, SEM and energy-dispersive spectroscopy, showed that the surfaces of the Ti and Ti 6 Al 4 V implants were affected by corundum blasting [20,21]. Moreover, contamination of the new and early removed femoral components made of the alloy Ti 6 Al 7 Nb with corundum wear particles was found also 5 to 20 µm below the surface [22], as the hard corundum wear particles were embedded into a softer matrix of Ti 6 Al 7 Nb alloy during the sandblasting process.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory, Oxidative Stress and Small Cellular Particle Response in HUVEC Induced by Debris from Endoprosthesis Processing

et al. 2023

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We studied inflammatory and oxidative stress-related parameters and cytotoxic response of human umbilical vein endothelial cells (HUVEC) to a 24 h treatment with milled particles simulating debris involved in sandblasting of orthopedic implants (OI). We used different abrasives (corundum—(Al2O3), used corundum retrieved from removed OI (u. Al2O3), and zirconia/silica composite (ZrO2/SiO2)). Morphological changes were observed by scanning electron microscopy (SEM). Concentration of Interleukins IL-6 and IL-1β and Tumor Necrosis Factor α (TNF)-α was assessed by enzyme-linked immunosorbent assay (ELISA). Activity of Cholinesterase (ChE) and Glutathione S-transferase (GST) was measured by spectrophotometry. Reactive oxygen species (ROS), lipid droplets (LD) and apoptosis were measured by flow cytometry (FCM). Detachment of the cells from glass and budding of the cell membrane did not differ in the treated and untreated control cells. Increased concentration of IL-1β and of IL-6 was found after treatment with all tested particle types, indicating inflammatory response of the treated cells. Increased ChE activity was found after treatment with u. Al2O3 and ZrO2/SiO2. Increased GST activity was found after treatment with ZrO2/SiO2. Increased LD quantity but not ROS quantity was found after treatment with u. Al2O3. No cytotoxicity was detected after treatment with u. Al2O3. The tested materials in concentrations added to in vitro cell lines were found non-toxic but bioactive and therefore prone to induce a response of the human body to OI.

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“…New femoral components were cleaned and sterilized at the manufacturer's site and special bags were opened on site just before surface chemistry and microstructure investigation. The cleaning and sterilization processes, according to the literature data and our experiences, do not affect the removal of the particle debris to be studied [16,19].…”

Section: Methodsmentioning

confidence: 99%

“…Here, we focused on premature failed Total Hip Arthroplasty (THA) due to aseptic loosening and periprosthetic infection. We investigated the grit-blasted surfaces of cementless ZM-type stems produced from Ti6Al7Nb alloy for which the corrosion resistance of the corundum grit-blasted and polished surface was previously investigated in electrochemical experiments, carried out in a simulated physiological Hank's solution [2,14,15] and the surface wettability was determined with contact angle and roughness [16].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Al2O3 Particles from Grit-Blasted Ti6Al7Nb (Alloy) Implant Surfaces on Biocompatibility, Aseptic Loosening, and Infection

Kocjančič,

Avsec,

Šetina Batič

et al. 2023

Materials

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For the improvement of surface roughness, titanium joint arthroplasty (TJA) components are grit-blasted with Al2O3 (corundum) particles during manufacturing. There is an acute concern, particularly with uncemented implants, about polymeric, metallic, and corundum debris generation and accumulation in TJA, and its association with osteolysis and implant loosening. The surface morphology, chemistry, phase analysis, and surface chemistry of retrieved and new Al2O3 grit-blasted titanium alloy were determined with scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and confocal laser fluorescence microscopy, respectively. Peri-prosthetic soft tissue was studied with histopathology. Blasted retrieved and new stems were exposed to human mesenchymal stromal stem cells (BMSCs) for 7 days to test biocompatibility and cytotoxicity. We found metallic particles in the peri-prosthetic soft tissue. Ti6Al7Nb with the residual Al2O3 particles exhibited a low cytotoxic effect while polished titanium and ceramic disks exhibited no cytotoxic effect. None of the tested materials caused cell death or even a zone of inhibition. Our results indicate a possible biological effect of the blasting debris; however, we found no significant toxicity with these materials. Further studies on the optimal size and properties of the blasting particles are indicated for minimizing their adverse biological effects.

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Effect of sterilization on the surface properties of Ti6Al7Nb alloy femoral stems

Cited by 6 publications

References 0 publications

Physicochemical and Antibacterial Evaluation of TiO2/CNT Mesoporous Nanomaterials Prepared by High-Pressure Hydrothermal Sol–Gel Method under an Ultrasonic Composite Environment

Physicochemical and Antibacterial Evaluation of TiO2/CNT Mesoporous Nanomaterials Prepared by High-Pressure Hydrothermal Sol–Gel Method under an Ultrasonic Composite Environment

Inflammatory, Oxidative Stress and Small Cellular Particle Response in HUVEC Induced by Debris from Endoprosthesis Processing

The Impact of Al2O3 Particles from Grit-Blasted Ti6Al7Nb (Alloy) Implant Surfaces on Biocompatibility, Aseptic Loosening, and Infection

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