Effect of Stimforte Upon Murine Mononuclear Leukocytes and Lymphoid Organs During Cyclophosphan Treatment

The combined action of the immunostimulatory drug Stimforte and the basic etiotropic drug acyclovir commonly used to treat herpes infections was studied using the model of lethal experimental infection of mice BALB/c with herpes simplex virus type 1. It was found that the interaction of these drugs is additive. In addition, Stimforte inhibits infection caused by a strain of virus, which is highly resistant to acyclovir. When administered 24 hours prior to HIV-1 infection of human lymphoblastoid cells MT-4, Stimforte exhibited reliable antiretroviral activity best expressed during the early period of infection (the 3rd day). On the 6th day of observation the effect was almost completely lost. Combined use of Stimforte at a dose of 50-100 µg/ml with a subthreshold dose of retrovir (0.03 µg/ml) had a synergistic antiviral effect. Thus, Stimforte, which exhibits, on the one hand, antiviral activity against viruses of different families and, on the other hand, the immunomodulatory properties, could be promising as an etiopathogenic tool in helping to normalize both nonspecific and specific immunity. It may be used simultaneously with etiotropic antiviral chemotherapy in treatment of generalized herpes infection in patients with immunodeficiency. Furthermore, Stimforte can be used in the case of development of drug resistance in HSV, in particular, in HIV-infected patients.

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The Mechanism of Stimforte Action on Herpesvirus Infection

Mal'dov¹,

Андронова²,

Григорян³

et al. 2018

Problems of Virology

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Increased protease activity and a significant amount of granzyme B were observed in in organs of mice infected with acute herpes simplex virus HSV-1 with the introduction of Stimforte (100 or 250 µg/mouse). Thus, this drug activates killer cells, which play an extremely important role in the suppression of HSV-1 infection. Although the administration of Stimforte (100 μg/mouse) to intact mice results in the activation of IFN-β production and does not activate the production of IFN-λ, Stimforte administration to animals infected with HSV-1 reduces production of IFN-β in serum, brain and lungs, whereas the production of IFN-λ considerably increases as the result of administration of 100 μg/mouse of Stimforte.

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Effect of Stimforte Upon Murine Mononuclear Leukocytes and Lymphoid Organs During Cyclophosphan Treatment

Cited by 3 publications

References 1 publication

The Mechanism of Suppression of Chronic Hepatitis C Infection by the Medicine Stimforte

The Mechanism of Suppression of Chronic Hepatitis C Infection by the Medicine Stimforte

Influence of Immunomodulatory Drug Stimforte on the Experimental Herpes Virus Infection in Combination With Acyclovir and on Hiv-Infection in Combination With Retrovir

The Mechanism of Stimforte Action on Herpesvirus Infection

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