Effect of Stimulation of the Host Defense System by Coenzyme Q
            <sub>10</sub>
            on Dibenzpyrene-Induced Tumors and Infection with Friend Leukemia Virus in Mice

Bliznakov, Emile G.

doi:10.1073/pnas.70.2.390

Cited by 27 publications

(13 citation statements)

References 24 publications

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“…In addition, CoQ 10 is a rate-limiting component of the mitochondrial electron transport system leading to ATP production which is essential for eukaryotic cell survival and energy requiring processes, including proliferation, apoptosis, angiogenesis, and immune function [5-8]. Epidemiological evidence, while limited, suggests inverse associations of tocopherols and CoQ 10 with the risk of certain cancers [9-11].…”

Section: Introductionmentioning

confidence: 99%

Serum Coenzyme Q₁₀, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Chai¹,

Novotny²,

Maskarinec³

et al. 2014

Journal of the American College of Nutrition

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Objective Lipid-soluble antioxidants are associated with a lower incidence for many chronic diseases of aging, possibly by preventing damage from chronic inflammation. In the current study, we compared serum levels of coenzyme Q10 (CoQ10), α-tocopherol, γ-tocopherol, and C-reactive protein (CRP) between adolescent girls and premenopausal women to assess changes from childhood to midlife. Methods Baseline serum CoQ10, α-tocopherol, γ-tocopherol, and CRP levels were measured in 207 girls (13-19 years) and 183 premenopausal women (34-47 years) using standard methods and the two age groups were compared by t-test. The influence of age, body mass index (BMI) and race/ethnicity and interaction effects on serum values were assessed using analysis of covariance. Pearson correlation coefficients were used to assess associations between pairs of lipid micronutrients. Results Overall, adolescent girls had significantly lower mean serum CoQ10, α-tocopherol, γ-tocopherol, and CRP levels relative to premenopausal women (CoQ10: 376 vs. 544 ng/mL, P<0.0001; α-tocopherol: 6.9 vs. 13.5 μg/mL, P<0.0001; γ-tocopherol: 1.3 vs. 1.7 μg/mL, P<0.0001; CRP: 1.29 vs. 2.13 mg/L, P<0.0001). The differences in CoQ10 and tocopherols remained significant after adjustment for BMI and race/ethnicity. CoQ10 was significantly and positively correlated to α- and γ-tocopherol, and BMI was positively associated with CRP and γ-tocopherol in both groups. Conclusions Lower serum CoQ10, α-tocopherol, γ-tocopherol, and CRP levels in adolescent girls compared to women suggests that adolescents may have a reduced need for antioxidants possibly due to their lower BMI and inflammatory status as indicated by CRP.

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Section: Introductionmentioning

confidence: 99%

Serum Coenzyme Q₁₀, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Chai¹,

Novotny²,

Maskarinec³

et al. 2014

Journal of the American College of Nutrition

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“…All mammalian cells are capable of synthesizing CoQ 10 (or closely related molecules) in a complex biosynthetic pathway involving the mevalonate pathway (also responsible for cholesterol and dolichol synthesis) and tyrosine, in a process dependent upon eight essential vitamins and nutrients (3,4). Mitochondrial energy production is essential for eukaryotic cell survival and CoQ 10 is a key molecule in all energy requiring processes, including proliferation, apoptosis, angiogenesis, and immune function (5–8), suggesting the potential for multiple roles in the initiation and progression of cancer. Despite the critical role of CoQ 10 in many cellular functions, its potential relationship with cancer development and progression has not received appropriate attention.…”

Section: Introductionmentioning

confidence: 99%

Low Plasma Coenzyme Q10 Levels and Breast Cancer Risk in Chinese Women

Cooney

Dai

Gao

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Low circulating levels of Coenzyme Q10 (CoQ10) have been associated with increased cancer incidence and poor prognosis for a number of cancer types, while a recent prospective study observed a positive association for CoQ10 with breast cancer risk. Methods We prospectively examined the association of plasma CoQ10 with breast cancer risk in a nested case-control study of Chinese women within the Shanghai Women's Health Study (SWHS). Pre-diagnostic plasma samples were obtained from 340 cases and 653 age-matched controls and analyzed for total CoQ10. Results A borderline significant inverse association for breast cancer incidence with plasma CoQ10 level was observed using a conditional logistic regression model adjusted for age and age at first live birth, which became significant after elimination of cases diagnosed within one year of blood draw (ptrend = 0.03). This association was independent of menopausal status. Plasma CoQ10 levels were also observed to be significantly associated with circulating γ-tocopherol (r = 0.50; p < 0.0001) and with α-tocopherol (r =0.38; p < 0.0001) levels. Conclusions Circulating levels of CoQ10 were generally low in this population and the observed association with breast cancer risk may be limited to those women with exceptionally low values. Impact This study reports an inverse relationship between circulating CoQ10 and breast cancer risk, while the only other prospective study of CoQ10 and breast cancer to date found a positive association. Lower levels of CoQ10 in the SWHS population suggests that the two studies may not be contradictory and indicates a possible non-linear (U-shaped) association of CoQ10 with risk.

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“…49 A study by Bliznakov illustrated that injected doses of CoQ 10 (150-750 µg) in mice significantly delayed the onset of 3,4,9,10-dibenzpyrene-induced tumor formation, decreased tumor size, and reduced mortality rates compared with mice that were not given a supplemental injection. 50 A more recent trial showed similar results in male Sprague-Dawley rats, where CoQ 10 supplementation (0.4 mg/kg/day) demonstrated therapeutic potential against trichloroacetic acid-induced hepatocellular carcinoma, mediated by the suppression of lipid peroxidation, the prevention of reduced glutathione depletion, and decreased elevations of tumor necrosis factor-α and nitric oxide in liver tissue. 51 CoQ 10 use with chemotherapy was shown to be effective in patients suffering from breast cancer.…”

Section: Cancermentioning

confidence: 50%

Potential role of coenzyme Q<sub>10</sub> in health and disease conditions

Rodick¹,

Seibels²,

Babu³

et al. 2018

NDS

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Coenzyme Q 10 (CoQ 10 ), an endogenously produced compound, is found in all human cells. Within the mitochondria, it plays a substantial role in energy production by acting as a mobile electron carrier in the electron transport chain. Outside the mitochondria, it acts as an excellent antioxidant by sequestering free radicals and working synergistically with other antioxidants, including vitamin E. Dietary contribution is limited, making endogenous production the primary source for optimal function. Now widely available as an over-the-counter supplement, CoQ 10 has gained attention for its possible therapeutic use in minimizing the outcomes of certain metabolic diseases, notably cardiovascular disease, diabetes, neurodegenerative disease, and cancer. Research has shown positive results in subjects supplemented with CoQ 10 , especially in relation to upregulating antioxidant capability. Emerging research suggests beneficial effects of CoQ 10 supplementation in individuals on statin medications. CoQ 10 supplementation in individuals participating in strenuous exercise seems to exert some beneficial effects, although the data are conflicting with other types of physical activity. This broad review of current CoQ 10 literature, while outlining its physiological/functional significance in health and disease conditions, also offers a dietitian's perspective on its potential use as a supplement in the promotion of health and management of disease conditions.

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Effect of Stimulation of the Host Defense System by Coenzyme Q ₁₀ on Dibenzpyrene-Induced Tumors and Infection with Friend Leukemia Virus in Mice

Cited by 27 publications

References 24 publications

Serum Coenzyme Q₁₀, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Serum Coenzyme Q₁₀, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Low Plasma Coenzyme Q10 Levels and Breast Cancer Risk in Chinese Women

Potential role of coenzyme Q<sub>10</sub> in health and disease conditions

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Effect of Stimulation of the Host Defense System by Coenzyme Q 10 on Dibenzpyrene-Induced Tumors and Infection with Friend Leukemia Virus in Mice

Cited by 27 publications

References 24 publications

Serum Coenzyme Q10, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Serum Coenzyme Q10, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Low Plasma Coenzyme Q10 Levels and Breast Cancer Risk in Chinese Women

Potential role of coenzyme Q<sub>10</sub> in health and disease conditions

Contact Info

Product

Resources

About

Effect of Stimulation of the Host Defense System by Coenzyme Q ₁₀ on Dibenzpyrene-Induced Tumors and Infection with Friend Leukemia Virus in Mice

Serum Coenzyme Q₁₀, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Serum Coenzyme Q₁₀, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females