Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

Gabriel, Damien; Veuillet, E.; Ragot, Richard; Schwartz, Denis; Ducorps, Antoine; Noreña, Arnaud; Durrant, John D.; Bonmartin, A.; Cotton, François; Collet, Lionel

doi:10.1016/j.heares.2004.07.015

Cited by 30 publications

(19 citation statements)

References 40 publications

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“…For monaural stimulation, 9 acceptable dipole localisations were obtained in each hemisphere out of a possible 11; and for dichotic stimulation 7 were obtained in the left and 5 in the right hemisphere (no significant differences; χ 2 , p > 0.05). Consistent with previous observations (e.g 252627…”

Section: Resultssupporting

confidence: 93%

“…Similarly, the ER beamformer analysis failed to show the expected trend for right-hemisphere N1m sources to lie slightly more anterior than those in the left hemisphere25262732, although this right-hemisphere anterior shift was seen in our dipole localisations. Again, it is possible that these subtle dissociations between localisations using the two methods reflect a difference in the topographical distributions of the underpinning physiological signals being localised by each method, i.e.…”

Section: Discussionmentioning

confidence: 52%

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Localising the auditory N1m with event-related beamformers: localisation accuracy following bilateral and unilateral stimulation

Gascoyne

Furlong

Hillebrand

et al. 2016

Sci Rep

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The auditory evoked N1m-P2m response complex presents a challenging case for MEG source-modelling, because symmetrical, phase-locked activity occurs in the hemispheres both contralateral and ipsilateral to stimulation. Beamformer methods, in particular, can be susceptible to localisation bias and spurious sources under these conditions. This study explored the accuracy and efficiency of event-related beamformer source models for auditory MEG data under typical experimental conditions: monaural and diotic stimulation; and whole-head beamformer analysis compared to a half-head analysis using only sensors from the hemisphere contralateral to stimulation. Event-related beamformer localisations were also compared with more traditional single-dipole models. At the group level, the event-related beamformer performed equally well as the single-dipole models in terms of accuracy for both the N1m and the P2m, and in terms of efficiency (number of successful source models) for the N1m. The results yielded by the half-head analysis did not differ significantly from those produced by the traditional whole-head analysis. Any localisation bias caused by the presence of correlated sources is minimal in the context of the inter-individual variability in source localisations. In conclusion, event-related beamformers provide a useful alternative to equivalent-current dipole models in localisation of auditory evoked responses.

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Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 52%

Localising the auditory N1m with event-related beamformers: localisation accuracy following bilateral and unilateral stimulation

Gascoyne

Furlong

Hillebrand

et al. 2016

Sci Rep

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“…N1m amplitude was largest for sub-edge tonal frequencies, intermediate for edge frequencies, and smallest for (surrogate) tinnitus frequencies. This is in agreement with the observation that, above approximately 1000 Hz, N1m amplitude decreases as a function of frequency (Pantev et al, 1995; Fujioka et al, 2002; Gabriel et al, 2004). These findings were preserved when age and hearing loss were entered as covariates into the analysis.…”

Section: Discussionsupporting

confidence: 91%

Is the effect of tinnitus on auditory steady-state response amplitude mediated by attention?

Diesch¹,

Andermann²,

Rupp³

2012

Front. Syst. Neurosci.

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Objectives: Auditory steady-state response (ASSR) amplitude enhancement effects have been reported in tinnitus patients. As ASSR amplitude is also enhanced by attention, the effect of tinnitus on ASSR amplitude could be interpreted as an effect of attention mediated by tinnitus. As N1 attention effects are significantly larger than those on the ASSR, if the effect of tinnitus on ASSR amplitude were due to attention, there should be similar amplitude enhancement effects in tinnitus for the N1 component of the auditory-evoked response. Methods: MEG recordings which were previously examined for the ASSR (Diesch et al., 2010a) were analyzed with respect to the N1m component. Like the ASSR previously, the N1m was analyzed in the source domain (source space projection). Stimuli were amplitude-modulated (AM) tones with one of three carrier frequencies matching the tinnitus frequency or a surrogate frequency 1½ octave above the audiometric edge frequency in controls, the audiometric edge frequency, and a frequency below the audiometric edge. Single AM-tones were presented in a single condition and superpositions of three AM-tones differing in carrier and modulation frequency in a composite condition. Results: In the earlier ASSR study (Diesch et al., 2010a), the ASSR amplitude in tinnitus patients, but not in controls, was significantly larger in the (surrogate) tinnitus condition than in the edge condition. Patients showed less evidence than controls of reciprocal inhibition of component ASSR responses in the composite condition. In the present study, N1m amplitudes elicited by stimuli located at the audiometric edge and at the (surrogate) tinnitus frequency were smaller than N1m amplitudes elicited by sub-edge tones both in patients and controls. The relationship of the N1m response in the composite condition to the N1m response in the single condition indicated that reciprocal inhibition among component N1m responses was reduced in patients compared against controls. Conclusions: In the present study, no evidence was found for an N1-amplitude enhancement effect in tinnitus. Compared to controls, reciprocal inhibition is reduced in tinnitus patients. Thus, as there is no effect on N1m that could potentially be attributed to attention, it seems unlikely that the enhancement effect of tinnitus on ASSR amplitude could be accounted for in terms of attention induced by tinnitus.

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“…The topographic changes observed may indeed reflect the resultant of the several different tonotopic maps that have been shown to exist in the human auditory cortex (Pantev et al, 1995; Formisano et al, 2003;Talavage et al, 2004). Gabriel et al (2004) proposed two hypotheses to explain variations of a single dipolar source in the auditory cortex. According to the first one, N1 would be attributable to one predominant generator and a few secondary activation areas, the dipolar source then reflecting one major tonotopic map.…”

Section: Discussionmentioning

confidence: 98%

“…The N1 topographic changes with the electrode of stimulation were observed over both hemiscalps, but were more significant over the ipsilateral hemisphere when all data were considered and more significant over the left hemisphere in subjects implanted on the right side. This observation was, however, difficult to interpret because, in normal-hearing subjects, it is unclear whether the tonotopic maps of the auditory cortex are similar for ipsilateral and contralateral or left and right stimulation Strainer et al, 1997;Pantev et al, 1998;Liegeois-Chauvel et al, 2001;Gabriel et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Evidence of a Tonotopic Organization of the Auditory Cortex in Cochlear Implant Users

Guiraud

Besle²,

Arnold³

et al. 2007

J. Neurosci.

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Deprivation from normal sensory input has been shown to alter tonotopic organization of the human auditory cortex. In this context, cochlear implant subjects provide an interesting model in that profound deafness is made partially reversible by the cochlear implant. In restoring afferent activity, cochlear implantation may also reverse some of the central changes related to deafness. The purpose of the present study was to address whether the auditory cortex of cochlear implant subjects is tonotopically organized. The subjects were thirteen adults with at least 3 months of cochlear implant experience. Auditory event-related potentials were recorded in response to electrical stimulation delivered at different intracochlear electrodes. Topographic analysis of the auditory N1 component (ϳ85 ms latency) showed that the locations on the scalp and the relative amplitudes of the positive/negative extrema differ according to the stimulated electrode, suggesting that distinct sets of neural sources are activated. Dipole modeling confirmed electrode-dependent orientations of these sources in temporal areas, which can be explained by nearby, but distinct sites of activation in the auditory cortex. Although the cortical organization in cochlear implant users is similar to the tonotopy found in normal-hearing subjects, some differences exist. Nevertheless, a correlation was found between the N1 peak amplitude indexing cortical tonotopy and the values given by the subjects for a pitch scaling task. Hence, the pattern of N1 variation likely reflects how frequencies are coded in the brain.

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Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

Cited by 30 publications

References 40 publications

Localising the auditory N1m with event-related beamformers: localisation accuracy following bilateral and unilateral stimulation

Localising the auditory N1m with event-related beamformers: localisation accuracy following bilateral and unilateral stimulation

Is the effect of tinnitus on auditory steady-state response amplitude mediated by attention?

Evidence of a Tonotopic Organization of the Auditory Cortex in Cochlear Implant Users

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