Effect of Storage Conditions on Compaction Behavior of Two Grades of Spray-Dried Lactose

Phase Transformation in Thiamine Hydrochloride Tablets: Influence on Tablet Microstructure, Physical Properties, and Performance

“…Sucrose crystallization in the compressed tablets during storage increased both the porosity and tablet hardness and rendered them suitable for use as orally disintegrating tablets 10. Crystallization of amorphous regions in spray‐dried lactose, after compression, has been shown to cause an increase in tablet tensile strength 11…”

Spray Drying for Direct Compression of Pharmaceuticals

“…Re-crystallization of the amorphous content in the tablets and bridge formation was considered the reason for the increase in tablet strength. Conversely, preexposure of the powder to moisture before compression reduced the compactability of both grades, which was ascribed to the conversion of amorphous content to crystalline before compression [57]. Finally, although it cannot be generalized, regular grades from different manufacturers appear to have similar qualities.…”