Effect of strain rate on the fracture behaviour of collagen

Arumugam, V.; Naresh, M.D.; Somanathan, N.; Sanjeevi, R.

doi:10.1007/bf00540684

Cited by 27 publications

(24 citation statements)

References 11 publications

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“…25 Furthermore, the presence of coagents could have enhanced the close packing of the fibers, as has been shown for composite fibers 26 and elastin-based materials. 27 The fracture modes identified were in accord with previous publications on collagen fibers and native tissues, [28][29][30][31] where their relative occurrence was attributed to the handling of the fibers, the strain rate, and possibly to flaws within the fibrous structure. More specific, when the application of load was slow, the fibers tended to break smoothly (smooth fracture).…”

Section: Structural Evaluationsupporting

confidence: 87%

Engineering extruded collagen fibers for biomedical applications

Zeugolis

Paul

Attenburrow

2008

J of Applied Polymer Sci

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Extruded collagen fibers constitute a promising biomimetic scaffold for tissue engineering applications. In this study, we compared the structural, thermal, and mechanical properties of fibers produced from either NaCl or poly(ethylene glycol) with a number-average molecular weight of 8000 (PEG 8K), the only two coagents that have been used in the fabrication process. As novel, we report the fabrication of fibers with properties similar to native or synthetic fibers using other coagents. NaCl derived fibers were characterized by higher thermal stability (p < 0.026), stress (p < 0.001), and modulus (p < 0.0025) values than PEG 8K, whereas the latter yielded more extendable fibers (p < 0.012). Poly(ethylene glycol)s with number-average molecular weights of 200 and 1000 produced fibers with similar mechanical properties (p > 0.05) that were thinner (p < 0.033), stiffer (p < 0.022), and less extendable (p < 0.0002) than those of PEG 8K. Poly(vinyl alcohol) (PVA) with a numberaverage average molecular weight of 9-10,000 and PEG 8K yielded fibers with similar diameters and stress-at-break values (p > 0.05); however, the poly(ethylene glycol) derived fibers were more extendable (p < 0.0003), whereas the PVA fibers were stiffer (p < 0.029). Gum-arabic-and solublestarch-derived fibers were of similar tensile strength, extendibility, and stiffness (p > 0.05). In this in vitro study, the thickest (p < 0.011) and the weakest (p < 0.0066) fibers were produced in the presence of sodium sulfate.

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Section: Structural Evaluationsupporting

confidence: 87%

Engineering extruded collagen fibers for biomedical applications

Zeugolis

Paul

Attenburrow

2008

J of Applied Polymer Sci

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“…The unique surface characteristics of the collagen fibres have been shown to enhance cell attachment and growth [63,64]. The four different fracture modes found are consistent with other studies on extruded and native fibres, and their relative occurrence has been variously attributed to the different degree of stretching of the different layers of the fibre, to the test strain rate and even to flaws within the fibre structure [22,23,26,27,30,[65][66][67][68][69]. More specifically, at low extension rates, the fibres tend to break smoothly (smooth fracture; Fig.…”

Section: Structural Characteristicssupporting

confidence: 70%

“…During loading of collagen fibres, collagen molecules, fibrils and fibril bundles deform and finally fail by a process termed defibrillation [20,23,29,43]. Age, length and diameter of the collagen fibres, sampling position, collagen content, presence of non-collagenous components and strain rate were found to play important roles in studies of collagenous tissue [23,53,65,67,[80][81][82][83][84]. In the dry state, s-shape stress-strain curves are observed similar to those of crystalline polymers that yield and undergo plastic flow [20,31,32], whilst in the wet state j-shaped stress-strain curves are found, as has been reported for rehydrated reformed collagen fibres derived from bovine corium [20,32], pericardium tissue [85] and rat tail tendon [24].…”

Section: Deformation Mechanism/stress-strain Curvesmentioning

confidence: 98%

Post-self-assembly experimentation on extruded collagen fibres for tissue engineering applications

2008

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“…The fracture pattern of the collagen fibers can be classified into three main patterns [21]: (1) fracture occurring in a single plane perpendicular to the fiber axis, or ‘smooth fracture’; (2) fracture starting as a smooth fracture but resulting in the splitting of the fiber along the axis, or ‘step fracture’; (3) fracture with a split open end resembling the bristles of a brush, or ‘fibrillation fracture’ [22]. These patterns have been found to be extremely characteristic in both collagen [23] and elastoidin fibers [24] tested at different strain rates. …”

Section: Potential Mechanisms Of Skin Fragility In Dermatoporosismentioning

confidence: 99%

Dermatoporosis: A Chronic Cutaneous Insufficiency/Fragility Syndrome

Kaya

Saurat²

2007

Dermatology

200

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Background: Skin aging has long been considered only as a cosmetic problem. With the increase in lifespan, we are now more often experiencing a further dimension of skin aging, which is no longer only cosmetic, but also functional, in the sense that the skin has lost its protective mechanical function. Dermatoporosis is the name proposed to capture, in a holistic approach, all the aspects of this chronic cutaneous insufficiency/fragility syndrome. Observations: In this paper, we review the clinical aspects of dermatoporosis, its histological features and the current understanding of its etiological factors. The clinical manifestations of dermatoporosis comprise (i) morphologicalmarkers of fragility – rather trivial – such as senile purpura, stellate pseudoscars and skin atrophy, and (ii) functional expression of skin fragility resulting from minor traumas such as frequent skin laceration, delayed wound healing, nonhealing atrophic ulcers and subcutaneous bleeding with the formation of dissecting hematomas leading to large zones of necrosis. Dissecting hematomas bear significant morbidity needing hospitalization and urgent surgical procedures. Molecular mechanisms implying hyaluronate-CD44 pathways in the control and maintenance of epithelial growth and the viscoelastic properties of the extracellular matrix offer new opportunities for preventive intervention. Conclusion: We propose to group the different manifestations and implications of this syndrome under the umbrella term of ‘dermatoporosis’,because we think it will helpto capture the understanding of health professionals that, as osteoporosis, ‘dermatoporosis’should be prevented and treated to avoid complications. Dermatologists should be aware of this emerging syndrome and function as key players in prevention and therapy. Randomized clinical trials should demonstrate which intervention may best prevent and/or reverse dermatoporosis.

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Effect of strain rate on the fracture behaviour of collagen

Cited by 27 publications

References 11 publications

Engineering extruded collagen fibers for biomedical applications

Engineering extruded collagen fibers for biomedical applications

Post-self-assembly experimentation on extruded collagen fibres for tissue engineering applications

Dermatoporosis: A Chronic Cutaneous Insufficiency/Fragility Syndrome

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